Allergen-specific IgG+ memory B cells are temporally linked to IgE memory responses

IgE is the least abundant immunoglobulin and tightly regulated, and IgE-producing B cells are rare. The cellular origin and evolution of IgE responses are poorly understood. The cellular and clonal origin of IgE memory responses following mucosal allergen exposure by sublingual immunotherapy (SLIT)...

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Veröffentlicht in:	Journal of allergy and clinical immunology 2020-07, Vol.146 (1), p.180-191
Hauptverfasser:	Hoof, Ilka, Schulten, Veronique, Layhadi, Janice A., Stranzl, Thomas, Christensen, Lars H., Herrera de la Mata, Sara, Seumois, Grégory, Vijayanand, Pandurangan, Lundegaard, Claus, Niss, Kristoffer, Lund, Anders, Ahrenfeldt, Johanne, Holm, Jens, Steveling, Esther, Sharif, Hanisah, Durham, Stephen R., Peters, Björn, Shamji, Mohamed H., Andersen, Peter S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Allergens - immunology B cells B-Lymphocytes - immunology B-Lymphocytes - pathology Double-Blind Method Female grass pollen allergy Humans IGe Immunoglobulin E - immunology Immunologic Memory Male memory B cells plasmablasts Pollen - immunology Rhinitis, Allergic, Seasonal - immunology Rhinitis, Allergic, Seasonal - pathology sublingual immunotherapy
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