CircRNA EPHB4 modulates stem properties and proliferation of gliomas via sponging miR‐637 and up‐regulating SOX10

Altered expression of circEPHB4, miR‐637 or SOX10 was independently associated with overall survival of glioma patients. By sponging miR‐637, circEPHB4 up‐regulated SOX10 and its target Nestin to promote stemness and self‐proliferation of glioma cells, stimulating the malignant progression of glioma...

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Veröffentlicht in:	Molecular oncology 2021-02, Vol.15 (2), p.596-622
Hauptverfasser:	Jin, Chen, Zhao, Jie, Zhang, Zhi‐Ping, Wu, Ming, Li, Jian, Liu, Bo, Bin Liao, Xin‐, Liao, Yu‐Xiang, Liu, Jing‐Ping
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Brain tumors Cancer cancer stemness Cell Line, Tumor circEPHB4 Female Glioma - genetics Glioma - metabolism Gliomas Humans Male Mice Mice, Inbred BALB C Mice, Nude MicroRNAs Middle Aged miR‐637 Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neoplastic Stem Cells - metabolism Neoplastic Stem Cells - pathology Oncology, Experimental proliferation RNA RNA, Circular - genetics RNA, Circular - metabolism RNA, Neoplasm - genetics RNA, Neoplasm - metabolism Scientific equipment and supplies industry SOX10 SOXE Transcription Factors - genetics SOXE Transcription Factors - metabolism Stem cells
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