Single-Cell Transcriptomic Heterogeneity in Invasive Ductal and Lobular Breast Cancer Cells

Invasive lobular breast carcinoma (ILC), one of the major breast cancer histologic subtypes, exhibits unique features compared with the well-studied ductal cancer subtype (IDC). The pathognomonic feature of ILC is loss of E-cadherin, mainly caused by inactivating mutations, but the contribution of t...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-01, Vol.81 (2), p.268-281
Hauptverfasser:	Chen, Fangyuan, Ding, Kai, Priedigkeit, Nolan, Elangovan, Ashuvinee, Levine, Kevin M, Carleton, Neil, Savariau, Laura, Atkinson, Jennifer M, Oesterreich, Steffi, Lee, Adrian V
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens, CD - genetics Antigens, CD - metabolism Biomarkers, Tumor - genetics Breast Neoplasms - genetics Breast Neoplasms - pathology Cadherins - antagonists & inhibitors Cadherins - genetics Cadherins - metabolism Carcinoma, Ductal, Breast - genetics Carcinoma, Ductal, Breast - pathology Carcinoma, Lobular - genetics Carcinoma, Lobular - pathology Female Gene Expression Regulation, Neoplastic Humans Mutation Prognosis Single-Cell Analysis - methods Transcriptome Tumor Cells, Cultured
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