Mice lacking substance P have normal bone modeling but diminished bone formation, increased resorption, and accelerated osteopenia with aging

Substance P (SP) is a sensory neuropeptide that is expressed by the neurons innervating bone. There is considerable evidence that SP can regulate bone cell function in vitro, but it is unclear whether SP modulates bone modeling or remodeling in vivo. To answer this question we characterized the bone...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2021-03, Vol.144, p.115806-115806, Article 115806
Hauptverfasser:	Wang, Liping, Hou, Saiyun, Sabsovich, Ilya, Guo, Tian-Zhi, Wei, Tzuping, Kingery, Wade S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging Animals Bone Bone and Bones Bone Diseases, Metabolic - genetics Bone remodeling Bone Resorption - genetics Mice Osteogenesis Osteopenia Substance P Substance P - genetics
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