Motor control and cognition deficits associated with protein carbamoylation in food (cassava) cyanogenic poisoning: Neurodegeneration and genomic perspectives

A case-control design determined whether konzo, an upper motoneuron disease linked to food (cassava) toxicity was associated with protein carbamoylation and genetic variations. Exon sequences of thiosulfate sulfurtransferase (TST) or mercaptopyruvate sulfurtransferase (MPST), plasma cyanide detoxifi...

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Veröffentlicht in:	Food and chemical toxicology 2021-02, Vol.148, p.111917-111917, Article 111917
Hauptverfasser:	Rwatambuga, F.A., Ali, E.R., Bramble, M.S., Gosschalk, J.E., Kim, Morris, Yandju, D.L., Okitundu, L.A., Boivin, M.J., Banea, J.P., Westaway, S.K., Larry, D., Vilain, Eric, Mumba Ngoyi, D., Tshala-Katumbay, D.D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Carbamoylation Case-Control Studies Cassava Child Cognitive Dysfunction - blood Cognitive Dysfunction - epidemiology Cognitive Dysfunction - genetics Cyanide Democratic Republic of the Congo Female Foodborne Diseases Humans Male Manihot - poisoning Models, Molecular Motor Neuron Disease - blood Motor Neuron Disease - epidemiology Motor Neuron Disease - genetics Neurodegeneration Polymorphism, Single Nucleotide Protein Carbamylation Serum Albumin, Human - analysis Serum Albumin, Human - metabolism Sulfurtransferases Sulfurtransferases - genetics Thiosulfate Sulfurtransferase - genetics
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