Synthesis and Multiplexed Activity Profiling of Synthetic Acylphloroglucinol Scaffolds

Reported here are novel formic‐acid‐mediated rearrangements of dearomatized acylphloroglucinols to access a structurally diverse group of synthetic acylphloroglucinol scaffolds (SASs). Density‐functional theory (DFT) optimized orbital and stereochemical analyses shed light on the mechanism of these...

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Veröffentlicht in:	Angewandte Chemie International Edition 2021-01, Vol.60 (3), p.1263-1272
Hauptverfasser:	Boyce, Jonathan H., Reisman, Benjamin J., Bachmann, Brian O., Porco, John A.
Format:	Artikel
Sprache:	eng
Schlagworte:	biomimetic synthesis Biomimetics cyclizations diversity-oriented synthesis inhibitors Markers Molecular Structure Multiplexing polycycles Scaffolds Signaling Synthesis Tissue Scaffolds - chemistry TOR protein
Online-Zugang:	Volltext
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