Gestational folate deficiency alters embryonic gene expression and cell function

Folic acid is a nutrient essential for embryonic development. Folate deficiency can cause embryonic lethality or neural tube defects and orofacial anomalies. Folate receptor 1 (Folr1) is a folate binding protein that facilitates the cellular uptake of dietary folate. To better understand the biologi...

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Veröffentlicht in:	Differentiation (London) 2021-01, Vol.117, p.1-15
Hauptverfasser:	Seelan, R.S., Mukhopadhyay, P., Philipose, J., Greene, R.M., Pisano, M.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actin Animals Apoptosis Blood coagulation Cardiomyocytes Cardiovascular system Cell Differentiation Cell migration Cytoskeleton Embryo cells Embryo, Mammalian - cytology Embryo, Mammalian - metabolism Embryogenesis Explants F-actin Female Folate Receptor 1 - physiology Folic acid Folic Acid - metabolism Folr1 Gene expression Gene Expression Profiling Gene Expression Regulation, Developmental Gestational Age Lethality Male Mice Mice, Inbred C57BL Mice, Knockout Neural crest Neural Crest - metabolism Neural Crest - pathology Neural crest cells Neural tube defects Neural Tube Defects - genetics Neural Tube Defects - metabolism Neural Tube Defects - pathology Proliferation Stem cells Systems development Transcription Vitamin B Vitamin deficiency
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