Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study
Purpose To examine the prospective association between serum Mg level and the incidence of cognitive impairment. Methods A random sub-cohort ( n = 2063) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was included in this study. Baseline serum Mg concentration was...
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| Veröffentlicht in: | European journal of nutrition 2021-04, Vol.60 (3), p.1511-1520 |
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| creator | Chen, Cheng Xun, Pengcheng Unverzagt, Frederick McClure, Leslie A. Irvin, Marguerite Ryan Judd, Suzanne Cushman, Mary He, Ka |
| description | Purpose
To examine the prospective association between serum Mg level and the incidence of cognitive impairment.
Methods
A random sub-cohort (
n
= 2063) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was included in this study. Baseline serum Mg concentration was measured using inductively coupled plasma mass spectrometry. According to the current reference interval of serum magnesium (0.75–0.95 mmol/L), we classified participants below the interval as Level 1 and used it as the referent. The rest of the study population were equally divided into three groups, named Level 2 to 4. Incident cognitive impairment was identified using the Six-Item Screener. Multivariable-adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using logistic regression models.
Results
After adjustment for potential confounders, an inverse threshold association between serum Mg level and incident cognitive impairment was observed. Compared to those with hypomagnesemia (Level 1: |
| doi_str_mv | 10.1007/s00394-020-02353-7 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7854858</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2504161760</sourcerecordid><originalsourceid>FETCH-LOGICAL-c474t-e96d1fb6df0e551b0bfa36cb3f1aff29118f2c65f3b1809d6d629a0d87e641643</originalsourceid><addsrcrecordid>eNp9kctu1TAQhiMEoqXwAiyQJTZsAmM7sRMWSKgqF6kSC2BtOfY4xyWxD3ZSqVueHPekHC4LFtaMZr75PaO_qp5SeEkB5KsMwPumBgbl8ZbX8l51ShsuasFoe_-YgzypHuV8BVAwQR9WJ5xJLgVlp9WPz5jWmcx6DJh9yUwMBsOS9OJjIDpY4oPxtpRKawx-8ddI_LzXPs2l-JosOyQJdY4hExcTGTGOSe933hymkzZeT8R65zBh0c5FkOQlxW9YwmpvHlcPnJ4yPrmLZ9XXdxdfzj_Ul5_efzx_e1mbRjZLjb2w1A3COsC2pQMMTnNhBu6odo71lHaOGdE6PtAOeiusYL0G20kUDRUNP6vebLr7dZjRbldOap_8rNONitqrvzvB79QYr5Xs2qZruyLw4k4gxe8r5kXNPhucJh0wrlmxhvVSAhVQ0Of_oFdxTaGcp1gLZR0qDxTbKJNizgndcRkK6tZitVmsisXqYLGSZejZn2ccR355WgC-Abm0wojp99__kf0JVeu1UA</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2504161760</pqid></control><display><type>article</type><title>Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Chen, Cheng ; Xun, Pengcheng ; Unverzagt, Frederick ; McClure, Leslie A. ; Irvin, Marguerite Ryan ; Judd, Suzanne ; Cushman, Mary ; He, Ka</creator><creatorcontrib>Chen, Cheng ; Xun, Pengcheng ; Unverzagt, Frederick ; McClure, Leslie A. ; Irvin, Marguerite Ryan ; Judd, Suzanne ; Cushman, Mary ; He, Ka</creatorcontrib><description>Purpose
To examine the prospective association between serum Mg level and the incidence of cognitive impairment.
Methods
A random sub-cohort (
n
= 2063) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was included in this study. Baseline serum Mg concentration was measured using inductively coupled plasma mass spectrometry. According to the current reference interval of serum magnesium (0.75–0.95 mmol/L), we classified participants below the interval as Level 1 and used it as the referent. The rest of the study population were equally divided into three groups, named Level 2 to 4. Incident cognitive impairment was identified using the Six-Item Screener. Multivariable-adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using logistic regression models.
Results
After adjustment for potential confounders, an inverse threshold association between serum Mg level and incident cognitive impairment was observed. Compared to those with hypomagnesemia (Level 1: < 0.75 mmol/L), the relative odds of incident cognitive impairment was reduced by 41% in the second level [OR (95% CI) = 0.59 (0.37, 0.94)]; higher serum Mg level did not provide further benefits [Level 3 and 4 versus Level 1: OR (95% CI) = 0.54 (0.34, 0.88) and 0.59 (0.36, 0.96),
P
for linear trend = 0.08].
Conclusions
Findings from this prospective study suggest that sufficient Mg status within the normal range may be beneficial to cognitive health in the US general population.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-020-02353-7</identifier><identifier>PMID: 32737612</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Brain research ; Chemistry ; Chemistry and Materials Science ; Cognition Disorders - epidemiology ; Cognitive ability ; Cognitive Dysfunction - epidemiology ; Humans ; Hypomagnesemia ; Incidence ; Magnesium ; Mass spectroscopy ; Nutrition ; Original Contribution ; Population studies ; Prospective Studies ; Race Factors ; Racial differences ; Regression analysis ; Risk Factors ; Stroke ; Stroke - epidemiology</subject><ispartof>European journal of nutrition, 2021-04, Vol.60 (3), p.1511-1520</ispartof><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020</rights><rights>Springer-Verlag GmbH Germany, part of Springer Nature 2020.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c474t-e96d1fb6df0e551b0bfa36cb3f1aff29118f2c65f3b1809d6d629a0d87e641643</citedby><cites>FETCH-LOGICAL-c474t-e96d1fb6df0e551b0bfa36cb3f1aff29118f2c65f3b1809d6d629a0d87e641643</cites><orcidid>0000-0003-1451-3889</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-020-02353-7$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-020-02353-7$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>230,314,780,784,885,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32737612$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Cheng</creatorcontrib><creatorcontrib>Xun, Pengcheng</creatorcontrib><creatorcontrib>Unverzagt, Frederick</creatorcontrib><creatorcontrib>McClure, Leslie A.</creatorcontrib><creatorcontrib>Irvin, Marguerite Ryan</creatorcontrib><creatorcontrib>Judd, Suzanne</creatorcontrib><creatorcontrib>Cushman, Mary</creatorcontrib><creatorcontrib>He, Ka</creatorcontrib><title>Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
To examine the prospective association between serum Mg level and the incidence of cognitive impairment.
Methods
A random sub-cohort (
n
= 2063) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was included in this study. Baseline serum Mg concentration was measured using inductively coupled plasma mass spectrometry. According to the current reference interval of serum magnesium (0.75–0.95 mmol/L), we classified participants below the interval as Level 1 and used it as the referent. The rest of the study population were equally divided into three groups, named Level 2 to 4. Incident cognitive impairment was identified using the Six-Item Screener. Multivariable-adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using logistic regression models.
Results
After adjustment for potential confounders, an inverse threshold association between serum Mg level and incident cognitive impairment was observed. Compared to those with hypomagnesemia (Level 1: < 0.75 mmol/L), the relative odds of incident cognitive impairment was reduced by 41% in the second level [OR (95% CI) = 0.59 (0.37, 0.94)]; higher serum Mg level did not provide further benefits [Level 3 and 4 versus Level 1: OR (95% CI) = 0.54 (0.34, 0.88) and 0.59 (0.36, 0.96),
P
for linear trend = 0.08].
Conclusions
Findings from this prospective study suggest that sufficient Mg status within the normal range may be beneficial to cognitive health in the US general population.</description><subject>Brain research</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Cognition Disorders - epidemiology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - epidemiology</subject><subject>Humans</subject><subject>Hypomagnesemia</subject><subject>Incidence</subject><subject>Magnesium</subject><subject>Mass spectroscopy</subject><subject>Nutrition</subject><subject>Original Contribution</subject><subject>Population studies</subject><subject>Prospective Studies</subject><subject>Race Factors</subject><subject>Racial differences</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><subject>Stroke</subject><subject>Stroke - epidemiology</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kctu1TAQhiMEoqXwAiyQJTZsAmM7sRMWSKgqF6kSC2BtOfY4xyWxD3ZSqVueHPekHC4LFtaMZr75PaO_qp5SeEkB5KsMwPumBgbl8ZbX8l51ShsuasFoe_-YgzypHuV8BVAwQR9WJ5xJLgVlp9WPz5jWmcx6DJh9yUwMBsOS9OJjIDpY4oPxtpRKawx-8ddI_LzXPs2l-JosOyQJdY4hExcTGTGOSe933hymkzZeT8R65zBh0c5FkOQlxW9YwmpvHlcPnJ4yPrmLZ9XXdxdfzj_Ul5_efzx_e1mbRjZLjb2w1A3COsC2pQMMTnNhBu6odo71lHaOGdE6PtAOeiusYL0G20kUDRUNP6vebLr7dZjRbldOap_8rNONitqrvzvB79QYr5Xs2qZruyLw4k4gxe8r5kXNPhucJh0wrlmxhvVSAhVQ0Of_oFdxTaGcp1gLZR0qDxTbKJNizgndcRkK6tZitVmsisXqYLGSZejZn2ccR355WgC-Abm0wojp99__kf0JVeu1UA</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Chen, Cheng</creator><creator>Xun, Pengcheng</creator><creator>Unverzagt, Frederick</creator><creator>McClure, Leslie A.</creator><creator>Irvin, Marguerite Ryan</creator><creator>Judd, Suzanne</creator><creator>Cushman, Mary</creator><creator>He, Ka</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-1451-3889</orcidid></search><sort><creationdate>20210401</creationdate><title>Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study</title><author>Chen, Cheng ; Xun, Pengcheng ; Unverzagt, Frederick ; McClure, Leslie A. ; Irvin, Marguerite Ryan ; Judd, Suzanne ; Cushman, Mary ; He, Ka</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c474t-e96d1fb6df0e551b0bfa36cb3f1aff29118f2c65f3b1809d6d629a0d87e641643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Brain research</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Cognition Disorders - epidemiology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - epidemiology</topic><topic>Humans</topic><topic>Hypomagnesemia</topic><topic>Incidence</topic><topic>Magnesium</topic><topic>Mass spectroscopy</topic><topic>Nutrition</topic><topic>Original Contribution</topic><topic>Population studies</topic><topic>Prospective Studies</topic><topic>Race Factors</topic><topic>Racial differences</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><topic>Stroke</topic><topic>Stroke - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Cheng</creatorcontrib><creatorcontrib>Xun, Pengcheng</creatorcontrib><creatorcontrib>Unverzagt, Frederick</creatorcontrib><creatorcontrib>McClure, Leslie A.</creatorcontrib><creatorcontrib>Irvin, Marguerite Ryan</creatorcontrib><creatorcontrib>Judd, Suzanne</creatorcontrib><creatorcontrib>Cushman, Mary</creatorcontrib><creatorcontrib>He, Ka</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Cheng</au><au>Xun, Pengcheng</au><au>Unverzagt, Frederick</au><au>McClure, Leslie A.</au><au>Irvin, Marguerite Ryan</au><au>Judd, Suzanne</au><au>Cushman, Mary</au><au>He, Ka</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>60</volume><issue>3</issue><spage>1511</spage><epage>1520</epage><pages>1511-1520</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
To examine the prospective association between serum Mg level and the incidence of cognitive impairment.
Methods
A random sub-cohort (
n
= 2063) from the Reasons for Geographic and Racial Differences in Stroke (REGARDS) cohort was included in this study. Baseline serum Mg concentration was measured using inductively coupled plasma mass spectrometry. According to the current reference interval of serum magnesium (0.75–0.95 mmol/L), we classified participants below the interval as Level 1 and used it as the referent. The rest of the study population were equally divided into three groups, named Level 2 to 4. Incident cognitive impairment was identified using the Six-Item Screener. Multivariable-adjusted odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using logistic regression models.
Results
After adjustment for potential confounders, an inverse threshold association between serum Mg level and incident cognitive impairment was observed. Compared to those with hypomagnesemia (Level 1: < 0.75 mmol/L), the relative odds of incident cognitive impairment was reduced by 41% in the second level [OR (95% CI) = 0.59 (0.37, 0.94)]; higher serum Mg level did not provide further benefits [Level 3 and 4 versus Level 1: OR (95% CI) = 0.54 (0.34, 0.88) and 0.59 (0.36, 0.96),
P
for linear trend = 0.08].
Conclusions
Findings from this prospective study suggest that sufficient Mg status within the normal range may be beneficial to cognitive health in the US general population.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>32737612</pmid><doi>10.1007/s00394-020-02353-7</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-1451-3889</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2021-04, Vol.60 (3), p.1511-1520 |
| issn | 1436-6207 1436-6215 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Brain research Chemistry Chemistry and Materials Science Cognition Disorders - epidemiology Cognitive ability Cognitive Dysfunction - epidemiology Humans Hypomagnesemia Incidence Magnesium Mass spectroscopy Nutrition Original Contribution Population studies Prospective Studies Race Factors Racial differences Regression analysis Risk Factors Stroke Stroke - epidemiology |
| title | Serum magnesium concentration and incident cognitive impairment: the reasons for geographic and racial differences in stroke study |
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