Myeloma-Modified Adipocytes Exhibit Metabolic Dysfunction and a Senescence-Associated Secretory Phenotype

Bone marrow adipocytes (BMAd) have recently been implicated in accelerating bone metastatic cancers, such as acute myelogenous leukemia and breast cancer. Importantly, bone marrow adipose tissue (BMAT) expands with aging and obesity, two key risk factors in multiple myeloma disease prevalence, sugge...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 2021-02, Vol.81 (3), p.634-647
Hauptverfasser:	Fairfield, Heather, Dudakovic, Amel, Khatib, Casper M, Farrell, Mariah, Costa, Samantha, Falank, Carolyne, Hinge, Maja, Murphy, Connor S, DeMambro, Victoria, Pettitt, Jessica A, Lary, Christine W, Driscoll, Heather E, McDonald, Michelle M, Kassem, Moustapha, Rosen, Clifford, Andersen, Thomas L, van Wijnen, Andre J, Jafari, Abbas, Reagan, Michaela R
Format:	Artikel
Sprache:	eng
Schlagworte:	3T3 Cells Adipocytes - metabolism Adipocytes - pathology Adipocytes - physiology Adipose Tissue - pathology Aging - pathology Animals Antineoplastic Agents, Hormonal - pharmacology Apoptosis - drug effects Biopsy Bone Marrow - drug effects Bone Marrow - pathology Bone Marrow Cells - pathology Cell Communication - physiology Cell Cycle - drug effects Cellular Senescence Coculture Techniques Cohort Studies Cytokines - metabolism Dexamethasone - pharmacology Disease Progression Drug Resistance, Neoplasm Female Gene Expression Humans Mice Mice, Inbred C57BL Mice, SCID Multiple Myeloma - drug therapy Multiple Myeloma - etiology Multiple Myeloma - pathology Obesity - pathology Phenotype
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