Depression: An actionable outcome for those at clinical high-risk
Comorbid diagnoses are common in youth who are at clinical high-risk (CHR) for developing psychosis, with depression being the most common. The aim of this paper is to examine depression over two years in a large sample of CHR youth who do not make the transition to psychosis, considering both categ...
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| Veröffentlicht in: | Schizophrenia research 2021-01, Vol.227, p.38-43 |
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| creator | Addington, Jean Farris, Megan S. Liu, Lu Cadenhead, Kristin S. Cannon, Tyrone D. Cornblatt, Barbara A. McGlashan, Thomas H. Perkins, Diana O. Seidman, Larry J. Tsuang, Ming T. Walker, Elaine F. Bearden, Carrie E. Mathalon, Daniel H. Stone, William S. Keshevan, Matcheri Woods, Scott W. |
| description | Comorbid diagnoses are common in youth who are at clinical high-risk (CHR) for developing psychosis, with depression being the most common. The aim of this paper is to examine depression over two years in a large sample of CHR youth who do not make the transition to psychosis, considering both categorical and dimensional ratings of depression severity. The sample consisted of 267 CHR youth who were followed for two years. Based on DSM-IV diagnoses over this time period, 100 CHR individuals never received a diagnosis of depression, 64 individuals continuously met criteria for depression, 92 individuals received a diagnosis of depression at one or more timepoints, and 11 participants had a diagnosis of depression only at 24-months. These groupings were supported by six-monthly ratings on the Calgary Depression Scale. The majority of this sample experienced a major depressive episode on more than one occasion, suggesting that depression and depressive symptoms identify a domain of substantial unmet clinical need. Recommendations are that depression in CHR youth and young adults should be monitored more frequently and that there is a need for clinical trials to address depression systematically in this vulnerable population. |
| doi_str_mv | 10.1016/j.schres.2020.10.001 |
| format | Article |
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The aim of this paper is to examine depression over two years in a large sample of CHR youth who do not make the transition to psychosis, considering both categorical and dimensional ratings of depression severity. The sample consisted of 267 CHR youth who were followed for two years. Based on DSM-IV diagnoses over this time period, 100 CHR individuals never received a diagnosis of depression, 64 individuals continuously met criteria for depression, 92 individuals received a diagnosis of depression at one or more timepoints, and 11 participants had a diagnosis of depression only at 24-months. These groupings were supported by six-monthly ratings on the Calgary Depression Scale. The majority of this sample experienced a major depressive episode on more than one occasion, suggesting that depression and depressive symptoms identify a domain of substantial unmet clinical need. Recommendations are that depression in CHR youth and young adults should be monitored more frequently and that there is a need for clinical trials to address depression systematically in this vulnerable population.</description><identifier>ISSN: 0920-9964</identifier><identifier>EISSN: 1573-2509</identifier><identifier>DOI: 10.1016/j.schres.2020.10.001</identifier><identifier>PMID: 33129638</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adolescent ; Clinical high-risk ; Depression ; Depression - epidemiology ; Depressive Disorder, Major - diagnosis ; Depressive Disorder, Major - epidemiology ; Diagnostic and Statistical Manual of Mental Disorders ; Humans ; Prognosis ; Psychosis ; Psychotic Disorders - epidemiology ; Symptoms ; Young Adult</subject><ispartof>Schizophrenia research, 2021-01, Vol.227, p.38-43</ispartof><rights>2020 Elsevier B.V.</rights><rights>Copyright © 2020 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c463t-b722527d7c23450235c9f63782bd381b4d54255487040deecb531d55487e33a43</citedby><cites>FETCH-LOGICAL-c463t-b722527d7c23450235c9f63782bd381b4d54255487040deecb531d55487e33a43</cites><orcidid>0000-0002-8298-0756</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.schres.2020.10.001$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33129638$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Addington, Jean</creatorcontrib><creatorcontrib>Farris, Megan S.</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Cadenhead, Kristin S.</creatorcontrib><creatorcontrib>Cannon, Tyrone D.</creatorcontrib><creatorcontrib>Cornblatt, Barbara A.</creatorcontrib><creatorcontrib>McGlashan, Thomas H.</creatorcontrib><creatorcontrib>Perkins, Diana O.</creatorcontrib><creatorcontrib>Seidman, Larry J.</creatorcontrib><creatorcontrib>Tsuang, Ming T.</creatorcontrib><creatorcontrib>Walker, Elaine F.</creatorcontrib><creatorcontrib>Bearden, Carrie E.</creatorcontrib><creatorcontrib>Mathalon, Daniel H.</creatorcontrib><creatorcontrib>Stone, William S.</creatorcontrib><creatorcontrib>Keshevan, Matcheri</creatorcontrib><creatorcontrib>Woods, Scott W.</creatorcontrib><title>Depression: An actionable outcome for those at clinical high-risk</title><title>Schizophrenia research</title><addtitle>Schizophr Res</addtitle><description>Comorbid diagnoses are common in youth who are at clinical high-risk (CHR) for developing psychosis, with depression being the most common. The aim of this paper is to examine depression over two years in a large sample of CHR youth who do not make the transition to psychosis, considering both categorical and dimensional ratings of depression severity. The sample consisted of 267 CHR youth who were followed for two years. Based on DSM-IV diagnoses over this time period, 100 CHR individuals never received a diagnosis of depression, 64 individuals continuously met criteria for depression, 92 individuals received a diagnosis of depression at one or more timepoints, and 11 participants had a diagnosis of depression only at 24-months. These groupings were supported by six-monthly ratings on the Calgary Depression Scale. The majority of this sample experienced a major depressive episode on more than one occasion, suggesting that depression and depressive symptoms identify a domain of substantial unmet clinical need. Recommendations are that depression in CHR youth and young adults should be monitored more frequently and that there is a need for clinical trials to address depression systematically in this vulnerable population.</description><subject>Adolescent</subject><subject>Clinical high-risk</subject><subject>Depression</subject><subject>Depression - epidemiology</subject><subject>Depressive Disorder, Major - diagnosis</subject><subject>Depressive Disorder, Major - epidemiology</subject><subject>Diagnostic and Statistical Manual of Mental Disorders</subject><subject>Humans</subject><subject>Prognosis</subject><subject>Psychosis</subject><subject>Psychotic Disorders - epidemiology</subject><subject>Symptoms</subject><subject>Young Adult</subject><issn>0920-9964</issn><issn>1573-2509</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kMtOwzAQRS0EoqXwBwhlySbBzzxYIFXlKVViA2vLcSaNSxoXO63E3-PSUmDDytadO3dmDkLnBCcEk_RqnnjdOPAJxXQjJRiTAzQkImMxFbg4RENcUBwXRcoH6MT7OQ4OgbNjNGCM0CJl-RCNb2EZQryx3XU07iKl-_BVZQuRXfXaLiCqrYv6xnqIVB_p1nRGqzZqzKyJnfFvp-ioVq2Hs907Qq_3dy-Tx3j6_PA0GU9jzVPWx2VGqaBZlWnKuMCUCV3UKctyWlYsJyWvBKdC8DzDHFcAuhSMVF8CMKY4G6Gbbe5yVS6g0tD1TrVy6cxCuQ9plZF_K51p5MyuZZYLznMaAi53Ac6-r8D3cmG8hrZVHdiVl5SLNBdFKkiw8q1VO-u9g3o_hmC5oS_ncktfbuhv1MA2tF38XnHf9I375wYIoNYGXEgx0GmojAPdy8qa_yd8Ahjtl0U</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Addington, Jean</creator><creator>Farris, Megan S.</creator><creator>Liu, Lu</creator><creator>Cadenhead, Kristin S.</creator><creator>Cannon, Tyrone D.</creator><creator>Cornblatt, Barbara A.</creator><creator>McGlashan, Thomas H.</creator><creator>Perkins, Diana O.</creator><creator>Seidman, Larry J.</creator><creator>Tsuang, Ming T.</creator><creator>Walker, Elaine F.</creator><creator>Bearden, Carrie E.</creator><creator>Mathalon, Daniel H.</creator><creator>Stone, William S.</creator><creator>Keshevan, Matcheri</creator><creator>Woods, Scott W.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-8298-0756</orcidid></search><sort><creationdate>20210101</creationdate><title>Depression: An actionable outcome for those at clinical high-risk</title><author>Addington, Jean ; Farris, Megan S. ; Liu, Lu ; Cadenhead, Kristin S. ; Cannon, Tyrone D. ; Cornblatt, Barbara A. ; McGlashan, Thomas H. ; Perkins, Diana O. ; Seidman, Larry J. ; Tsuang, Ming T. ; Walker, Elaine F. ; Bearden, Carrie E. ; Mathalon, Daniel H. ; Stone, William S. ; Keshevan, Matcheri ; Woods, Scott W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c463t-b722527d7c23450235c9f63782bd381b4d54255487040deecb531d55487e33a43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Clinical high-risk</topic><topic>Depression</topic><topic>Depression - epidemiology</topic><topic>Depressive Disorder, Major - diagnosis</topic><topic>Depressive Disorder, Major - epidemiology</topic><topic>Diagnostic and Statistical Manual of Mental Disorders</topic><topic>Humans</topic><topic>Prognosis</topic><topic>Psychosis</topic><topic>Psychotic Disorders - epidemiology</topic><topic>Symptoms</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Addington, Jean</creatorcontrib><creatorcontrib>Farris, Megan S.</creatorcontrib><creatorcontrib>Liu, Lu</creatorcontrib><creatorcontrib>Cadenhead, Kristin S.</creatorcontrib><creatorcontrib>Cannon, Tyrone D.</creatorcontrib><creatorcontrib>Cornblatt, Barbara A.</creatorcontrib><creatorcontrib>McGlashan, Thomas H.</creatorcontrib><creatorcontrib>Perkins, Diana O.</creatorcontrib><creatorcontrib>Seidman, Larry J.</creatorcontrib><creatorcontrib>Tsuang, Ming T.</creatorcontrib><creatorcontrib>Walker, Elaine F.</creatorcontrib><creatorcontrib>Bearden, Carrie E.</creatorcontrib><creatorcontrib>Mathalon, Daniel H.</creatorcontrib><creatorcontrib>Stone, William S.</creatorcontrib><creatorcontrib>Keshevan, Matcheri</creatorcontrib><creatorcontrib>Woods, Scott W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Schizophrenia research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Addington, Jean</au><au>Farris, Megan S.</au><au>Liu, Lu</au><au>Cadenhead, Kristin S.</au><au>Cannon, Tyrone D.</au><au>Cornblatt, Barbara A.</au><au>McGlashan, Thomas H.</au><au>Perkins, Diana O.</au><au>Seidman, Larry J.</au><au>Tsuang, Ming T.</au><au>Walker, Elaine F.</au><au>Bearden, Carrie E.</au><au>Mathalon, Daniel H.</au><au>Stone, William S.</au><au>Keshevan, Matcheri</au><au>Woods, Scott W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Depression: An actionable outcome for those at clinical high-risk</atitle><jtitle>Schizophrenia research</jtitle><addtitle>Schizophr Res</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>227</volume><spage>38</spage><epage>43</epage><pages>38-43</pages><issn>0920-9964</issn><eissn>1573-2509</eissn><abstract>Comorbid diagnoses are common in youth who are at clinical high-risk (CHR) for developing psychosis, with depression being the most common. The aim of this paper is to examine depression over two years in a large sample of CHR youth who do not make the transition to psychosis, considering both categorical and dimensional ratings of depression severity. The sample consisted of 267 CHR youth who were followed for two years. Based on DSM-IV diagnoses over this time period, 100 CHR individuals never received a diagnosis of depression, 64 individuals continuously met criteria for depression, 92 individuals received a diagnosis of depression at one or more timepoints, and 11 participants had a diagnosis of depression only at 24-months. These groupings were supported by six-monthly ratings on the Calgary Depression Scale. The majority of this sample experienced a major depressive episode on more than one occasion, suggesting that depression and depressive symptoms identify a domain of substantial unmet clinical need. 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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adolescent Clinical high-risk Depression Depression - epidemiology Depressive Disorder, Major - diagnosis Depressive Disorder, Major - epidemiology Diagnostic and Statistical Manual of Mental Disorders Humans Prognosis Psychosis Psychotic Disorders - epidemiology Symptoms Young Adult |
| title | Depression: An actionable outcome for those at clinical high-risk |
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