Engineering Tolerance toward Allogeneic CAR-T Cells by Regulation of MHC Surface Expression with Human Herpes Virus-8 Proteins

Allogeneic, off-the-shelf (OTS) chimeric antigen receptor (CAR) cell therapies have the potential to reduce manufacturing costs and variability while providing broader accessibility to cancer patients and those with other diseases. However, host-versus-graft reactivity can limit the durability and e...

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Veröffentlicht in:	Molecular therapy 2021-02, Vol.29 (2), p.718-733
Hauptverfasser:	Wang, Xiaomei, Cabrera, Fabricio G., Sharp, Kelly L., Spencer, David M., Foster, Aaron E., Bayle, J. Henri
Format:	Artikel
Sprache:	eng
Schlagworte:	allogeneic cell therapy Animals Biotechnology & Applied Microbiology CAR-T cell Cell- and Tissue-Based Therapy - methods Disease Models, Animal Genetic Engineering Genetics & Heredity Herpesvirus 8, Human - immunology HHV8 Histocompatibility Antigens - immunology Humans iMC immune evasion Immunotherapy, Adoptive - methods Life Sciences & Biomedicine MARCH proteins Medicine, Research & Experimental Mice Neoplasms - immunology Neoplasms - therapy off-the-shelf cell therapy Original OTS Research & Experimental Medicine Science & Technology Viral Proteins - immunology Xenograft Model Antitumor Assays
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