Yolk sac-derived Pdcd11-positive cells modulate zebrafish microglia differentiation through the NF-κB-Tgfβ1 pathway

Microglia are the primary immune cells in the central nervous system, which plays a vital role in neuron development and neurodegenerative diseases. Microglial precursors in peripheral hematopoietic tissues colonize the central nervous system during early embryogenesis. However, how intrinsic and ex...

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Veröffentlicht in:	Cell death and differentiation 2021, Vol.28 (1), p.170-183
Hauptverfasser:	Yang, Ruimeng, Zhan, Ming, Guo, Miaomiao, Yuan, Hao, Wang, Yiqin, Zhang, Yiyue, Zhang, Wenqing, Chen, Saijuan, de The, Hugues, Chen, Zhu, Zhou, Jun, Zhu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/105 13/109 13/21 13/31 13/44 13/51 13/95 14/1 14/5 45/77 631/337 631/80 64/116 82/80 Animals Apoptosis Biochemistry Biomedical and Life Sciences Brain - metabolism Cell Biology Cell Cycle Analysis Cell death Cell differentiation Cell Differentiation - physiology Cellular Biology Central nervous system Colonization Cytokines - metabolism Danio rerio Development Biology Embryogenesis Fertilization Hemopoiesis Inflammation Inflammation - metabolism Leukocytes (neutrophilic) Life Sciences Macrophages Macrophages - metabolism Microglia Microglia - metabolism Nervous system Neurobiology Neurodegenerative diseases Neurogenesis Neurons and Cognition NF-kappa B - metabolism NF-κB protein Signal Transduction Stem Cells Subcellular Processes Substantia alba Transforming Growth Factor beta1 - metabolism Transforming growth factor-b1 Yolk Yolk sac Yolk Sac - metabolism Zebrafish Zebrafish Proteins - metabolism
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