PIAS1 and TIF1γ collaborate to promote SnoN SUMOylation and suppression of epithelial–mesenchymal transition

SUMO E3 ligases specify protein substrates for SUMOylation. The SUMO E3 ligases PIAS1 and TIF1γ target the transcriptional regulator SnoN for SUMOylation leading to suppression of epithelial–mesenchymal transition (EMT). Whether and how TIF1γ and PIAS1 might coordinate SnoN SUMOylation and regulatio...

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Veröffentlicht in:	Cell death and differentiation 2021-01, Vol.28 (1), p.267-282
Hauptverfasser:	Chanda, Ayan, Ikeuchi, Yoshiho, Karve, Kunal, Sarkar, Anusi, Chandhoke, Amrita Singh, Deng, Lili, Bonni, Azad, Bonni, Shirin
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 13/89 13/95 14/34 14/5 14/63 38/77 631/337 631/45/612/645 631/67/322 631/80/79/1902 82/29 82/80 96/21 96/44 Animals Apoptosis Biochemistry Biomedical and Life Sciences Breast Cell Biology Cell Culture Techniques, Three Dimensional Cell Cycle Analysis Cell Line, Tumor Collaboration Epithelial-Mesenchymal Transition - genetics Gene Expression Regulation HEK293 Cells Humans Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Life Sciences Mesenchyme Mice Organoids Protein Binding Protein Inhibitors of Activated STAT - genetics Protein Inhibitors of Activated STAT - metabolism Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Small Ubiquitin-Related Modifier Proteins - genetics Small Ubiquitin-Related Modifier Proteins - metabolism Stem Cells SUMO protein Sumoylation - genetics Transcription Transcription Factors - genetics Transcription Factors - metabolism Ubiquitin-Protein Ligases - metabolism
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