Urolithin A suppresses high glucose-induced neuronal amyloidogenesis by modulating TGM2-dependent ER-mitochondria contacts and calcium homeostasis

Hyperglycemia in diabetes mellitus (DM) patients is a causative factor for amyloidogenesis and induces neuropathological changes, such as impaired neuronal integrity, neurodegeneration, and cognitive impairment. Regulation of mitochondrial calcium influx from the endoplasmic reticulum (ER) is consid...

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Veröffentlicht in:	Cell death and differentiation 2021-01, Vol.28 (1), p.184-202
Hauptverfasser:	Lee, Hyun Jik, Jung, Young Hyun, Choi, Gee Euhn, Kim, Jun Sung, Chae, Chang Woo, Lim, Jae Ryong, Kim, Seo Yihl, Yoon, Jee Hyeon, Cho, Ji Hyeon, Lee, Sei-Jung, Han, Ho Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	13 13/31 14 38 38/89 59 631/378/2612 631/443/810 64 96 Alzheimer Disease - metabolism Alzheimer Disease - prevention & control Alzheimer's disease Amyloid beta-Peptides - drug effects Amyloid beta-Peptides - metabolism Amyloid precursor protein Amyloidogenesis Animals Apoptosis Biochemistry Biomedical and Life Sciences Calcium (mitochondrial) Calcium (reticular) Calcium - metabolism Calcium homeostasis Calcium influx Cell Biology Cell Cycle Analysis Cell death Cell Line, Tumor Cognitive ability Coumarins - pharmacology Diabetes mellitus Disease Models, Animal Endoplasmic reticulum Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Glucose Glucose - metabolism Homeostasis Humans Hyperglycemia Inositol 1,4,5-trisphosphate receptors Intestinal microflora Life Sciences Male Metabolites Mice Mitochondria Mitochondria - drug effects Mitochondria - metabolism Neurodegeneration Neurodegenerative diseases Neurons - drug effects Neurons - metabolism Neuroprotection Pathogenesis Phosphorylation Protein Glutamine gamma Glutamyltransferase 2 - metabolism Secretase Stem Cells Voltage-Dependent Anion Channel 1 - metabolism β-Site APP-cleaving enzyme 1
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