NEO100 enables brain delivery of blood‒brain barrier impermeable therapeutics

Abstract Background Intracarotid injection of mannitol has been applied for decades to support brain entry of therapeutics that otherwise do not effectively cross the blood–brain barrier (BBB). However, the elaborate and high-risk nature of this procedure has kept its use restricted to well-equipped...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2021-01, Vol.23 (1), p.63-75
Hauptverfasser:	Wang, Weijun, Marín-Ramos, Nagore I, He, Haiping, Zeng, Shan, Cho, Hee-Yeon, Swenson, Stephen D, Zheng, Long, Epstein, Alan L, Schönthal, Axel H, Hofman, Florence M, Chen, Ligang, Chen, Thomas C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Basic and Translational Investigations Blood-Brain Barrier Brain Endothelial Cells Humans Mice Monoterpenes Tight Junctions
Online-Zugang:	Volltext
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