The Feasibility of High-Intensity Interval Training in Patients with Intensive Care Unit-Acquired Weakness Syndrome Following Long-Term Invasive Ventilation
Background Intensive care unit-acquired weakness syndrome (ICUAWS) can be a consequence of long-term mechanical ventilation. Despite recommendations of early patient mobilisation, little is known about the feasibility, safety and benefit of interval training in early rehabilitation facilities (ERF)...
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| Veröffentlicht in: | Sports Medicine - Open 2021-02, Vol.7 (1), p.11, Article 11 |
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| creator | Wernhart, Simon Hedderich, Jürgen Wunderlich, Svenja Schauerte, Kunigunde Weihe, Eberhard Dellweg, Dominic Siemon, Karsten |
| description | Background
Intensive care unit-acquired weakness syndrome (ICUAWS) can be a consequence of long-term mechanical ventilation. Despite recommendations of early patient mobilisation, little is known about the feasibility, safety and benefit of interval training in early rehabilitation facilities (ERF) after long-term invasive ventilation.
Methods and Results
We retrospectively analysed two established training protocols of bicycle ergometry in ERF patients after long-term (> 7 days) invasive ventilation (
n
= 46). Patients conducted moderate continuous (MCT,
n
= 24, mean age 70.3 ± 10.1 years) or high-intensity interval training (HIIT,
n
= 22, mean age 63.6 ± 12.6 years). The intensity of training was monitored with the BORG CR10 scale (intense phases ≥ 7/10 and moderate phases ≤ 4/10 points). The primary outcome was improvement (∆-values) of six-minute-walk-test (6 MWT), while the secondary outcomes were improvement of vital capacity (VC
max
), forced expiratory volume in 1 s (FEV
1
), maximal inspiratory pressure (PI
max
) and functional capabilities (functional independence assessment measure, FIM/FAM and Barthel scores) after 3 weeks of training. No adverse events were observed. There was a trend towards a greater improvement of 6 MWT in HIIT than MCT (159.5 ± 64.9 m vs. 120.4 ± 60.4 m;
p
= .057), despite more days of invasive ventilation (39.6 ± 16.8 days vs. 26.8 ± 16.2 days;
p
= .009). VC
max
(∆0.5l ± 0.6 vs. ∆0.5l ± 0.3;
p
= .462), FEV
1
(∆0.2l ± 0.3 vs. ∆0.3l ± 0.2;
p
= .218) PI
max
(∆0.8 ± 1.1 kPa vs. ∆0.7 ± 1.3pts;
p
= .918) and functional status (FIM/FAM: ∆29.0 ± 14.8pts vs. ∆30.9 ± 16.0pts;
p
= .707; Barthel: ∆28.9 ± 16.0 pts vs. ∆25.0 ± 10.5pts;
p
= .341) improved in HIIT and MCT.
Conclusions
We demonstrate the feasibility and safety of HIIT in the early rehabilitation of ICUAWS patients. Larger trials are necessary to find adequate dosage of HIIT in ICUAWS patients. |
| doi_str_mv | 10.1186/s40798-021-00299-6 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7849616</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A650459126</galeid><sourcerecordid>A650459126</sourcerecordid><originalsourceid>FETCH-LOGICAL-c513t-3b0fd055712d79bb1daf2ea88b7ce5a6c967543714546ff4e38074fb99cb4a6e3</originalsourceid><addsrcrecordid>eNp9ks9u1DAQxiMEolXpC3BAlji7-F_s-IK0WlFaaSWQ2MLRcpJJ1pC1Wzu71b4LD4uzWQpckA8ezXzz82fNFMVrSq4oreS7JIjSFSaMYkKY1lg-K84ZzSmtJH1-jDWmVJGz4jIlV5OSCCE44S-LM85LpnL9vPi53gC6BpsFbnDjAYUO3bh-g2_9CD5NmSmKezugdbTOO98j59FnOzrwY0KPbtygk3gPaGkjoDvvRrxoHnYuQou-gf3hISX05eDbGLb5vTAM4XEirYLv8RriNiP29kj4mrFuyPjgXxUvOjskuDzdF8Xd9Yf18gavPn28XS5WuCkpHzGvSdeSslSUtUrXNW1tx8BWVa0aKK1stFSl4IqKUsiuE8ArokRXa93UwkrgF8X7mXu_q7fQNtlBtIO5j25r48EE68y_Fe82pg97oyqhJZUZ8PYEiOFhB2k038Mu-uzZsJLrSjPOJtXVrOrtAMb5LmRYk08LW9cED53L-YXMgyo1PTawuaGJIaUI3ZMlSsy0BWbeApO3wBy3wExNb_7-zFPL75lnAZ8FKZd8D_GP2f9gfwG8vsE2</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2539892326</pqid></control><display><type>article</type><title>The Feasibility of High-Intensity Interval Training in Patients with Intensive Care Unit-Acquired Weakness Syndrome Following Long-Term Invasive Ventilation</title><source>Springer Open Access</source><source>EZB Free E-Journals</source><source>DOAJ Directory of Open Access Journals</source><source>SpringerLink (Online service)</source><source>PubMed Central</source><source>PubMed Central Open Access</source><creator>Wernhart, Simon ; Hedderich, Jürgen ; Wunderlich, Svenja ; Schauerte, Kunigunde ; Weihe, Eberhard ; Dellweg, Dominic ; Siemon, Karsten</creator><creatorcontrib>Wernhart, Simon ; Hedderich, Jürgen ; Wunderlich, Svenja ; Schauerte, Kunigunde ; Weihe, Eberhard ; Dellweg, Dominic ; Siemon, Karsten</creatorcontrib><description>Background
Intensive care unit-acquired weakness syndrome (ICUAWS) can be a consequence of long-term mechanical ventilation. Despite recommendations of early patient mobilisation, little is known about the feasibility, safety and benefit of interval training in early rehabilitation facilities (ERF) after long-term invasive ventilation.
Methods and Results
We retrospectively analysed two established training protocols of bicycle ergometry in ERF patients after long-term (> 7 days) invasive ventilation (
n
= 46). Patients conducted moderate continuous (MCT,
n
= 24, mean age 70.3 ± 10.1 years) or high-intensity interval training (HIIT,
n
= 22, mean age 63.6 ± 12.6 years). The intensity of training was monitored with the BORG CR10 scale (intense phases ≥ 7/10 and moderate phases ≤ 4/10 points). The primary outcome was improvement (∆-values) of six-minute-walk-test (6 MWT), while the secondary outcomes were improvement of vital capacity (VC
max
), forced expiratory volume in 1 s (FEV
1
), maximal inspiratory pressure (PI
max
) and functional capabilities (functional independence assessment measure, FIM/FAM and Barthel scores) after 3 weeks of training. No adverse events were observed. There was a trend towards a greater improvement of 6 MWT in HIIT than MCT (159.5 ± 64.9 m vs. 120.4 ± 60.4 m;
p
= .057), despite more days of invasive ventilation (39.6 ± 16.8 days vs. 26.8 ± 16.2 days;
p
= .009). VC
max
(∆0.5l ± 0.6 vs. ∆0.5l ± 0.3;
p
= .462), FEV
1
(∆0.2l ± 0.3 vs. ∆0.3l ± 0.2;
p
= .218) PI
max
(∆0.8 ± 1.1 kPa vs. ∆0.7 ± 1.3pts;
p
= .918) and functional status (FIM/FAM: ∆29.0 ± 14.8pts vs. ∆30.9 ± 16.0pts;
p
= .707; Barthel: ∆28.9 ± 16.0 pts vs. ∆25.0 ± 10.5pts;
p
= .341) improved in HIIT and MCT.
Conclusions
We demonstrate the feasibility and safety of HIIT in the early rehabilitation of ICUAWS patients. Larger trials are necessary to find adequate dosage of HIIT in ICUAWS patients.</description><identifier>ISSN: 2199-1170</identifier><identifier>EISSN: 2198-9761</identifier><identifier>DOI: 10.1186/s40798-021-00299-6</identifier><identifier>PMID: 33527199</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Intensive care ; Interval training ; Medicine ; Medicine & Public Health ; Original ; Original Research Article ; Sports Medicine ; Ventilators</subject><ispartof>Sports Medicine - Open, 2021-02, Vol.7 (1), p.11, Article 11</ispartof><rights>The Author(s) 2021</rights><rights>COPYRIGHT 2021 Springer</rights><rights>The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c513t-3b0fd055712d79bb1daf2ea88b7ce5a6c967543714546ff4e38074fb99cb4a6e3</citedby><cites>FETCH-LOGICAL-c513t-3b0fd055712d79bb1daf2ea88b7ce5a6c967543714546ff4e38074fb99cb4a6e3</cites><orcidid>0000-0001-6732-0939</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849616/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7849616/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,41096,41464,42165,42533,51294,51551,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33527199$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wernhart, Simon</creatorcontrib><creatorcontrib>Hedderich, Jürgen</creatorcontrib><creatorcontrib>Wunderlich, Svenja</creatorcontrib><creatorcontrib>Schauerte, Kunigunde</creatorcontrib><creatorcontrib>Weihe, Eberhard</creatorcontrib><creatorcontrib>Dellweg, Dominic</creatorcontrib><creatorcontrib>Siemon, Karsten</creatorcontrib><title>The Feasibility of High-Intensity Interval Training in Patients with Intensive Care Unit-Acquired Weakness Syndrome Following Long-Term Invasive Ventilation</title><title>Sports Medicine - Open</title><addtitle>Sports Med - Open</addtitle><addtitle>Sports Med Open</addtitle><description>Background
Intensive care unit-acquired weakness syndrome (ICUAWS) can be a consequence of long-term mechanical ventilation. Despite recommendations of early patient mobilisation, little is known about the feasibility, safety and benefit of interval training in early rehabilitation facilities (ERF) after long-term invasive ventilation.
Methods and Results
We retrospectively analysed two established training protocols of bicycle ergometry in ERF patients after long-term (> 7 days) invasive ventilation (
n
= 46). Patients conducted moderate continuous (MCT,
n
= 24, mean age 70.3 ± 10.1 years) or high-intensity interval training (HIIT,
n
= 22, mean age 63.6 ± 12.6 years). The intensity of training was monitored with the BORG CR10 scale (intense phases ≥ 7/10 and moderate phases ≤ 4/10 points). The primary outcome was improvement (∆-values) of six-minute-walk-test (6 MWT), while the secondary outcomes were improvement of vital capacity (VC
max
), forced expiratory volume in 1 s (FEV
1
), maximal inspiratory pressure (PI
max
) and functional capabilities (functional independence assessment measure, FIM/FAM and Barthel scores) after 3 weeks of training. No adverse events were observed. There was a trend towards a greater improvement of 6 MWT in HIIT than MCT (159.5 ± 64.9 m vs. 120.4 ± 60.4 m;
p
= .057), despite more days of invasive ventilation (39.6 ± 16.8 days vs. 26.8 ± 16.2 days;
p
= .009). VC
max
(∆0.5l ± 0.6 vs. ∆0.5l ± 0.3;
p
= .462), FEV
1
(∆0.2l ± 0.3 vs. ∆0.3l ± 0.2;
p
= .218) PI
max
(∆0.8 ± 1.1 kPa vs. ∆0.7 ± 1.3pts;
p
= .918) and functional status (FIM/FAM: ∆29.0 ± 14.8pts vs. ∆30.9 ± 16.0pts;
p
= .707; Barthel: ∆28.9 ± 16.0 pts vs. ∆25.0 ± 10.5pts;
p
= .341) improved in HIIT and MCT.
Conclusions
We demonstrate the feasibility and safety of HIIT in the early rehabilitation of ICUAWS patients. Larger trials are necessary to find adequate dosage of HIIT in ICUAWS patients.</description><subject>Intensive care</subject><subject>Interval training</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original</subject><subject>Original Research Article</subject><subject>Sports Medicine</subject><subject>Ventilators</subject><issn>2199-1170</issn><issn>2198-9761</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>C6C</sourceid><sourceid>BENPR</sourceid><recordid>eNp9ks9u1DAQxiMEolXpC3BAlji7-F_s-IK0WlFaaSWQ2MLRcpJJ1pC1Wzu71b4LD4uzWQpckA8ezXzz82fNFMVrSq4oreS7JIjSFSaMYkKY1lg-K84ZzSmtJH1-jDWmVJGz4jIlV5OSCCE44S-LM85LpnL9vPi53gC6BpsFbnDjAYUO3bh-g2_9CD5NmSmKezugdbTOO98j59FnOzrwY0KPbtygk3gPaGkjoDvvRrxoHnYuQou-gf3hISX05eDbGLb5vTAM4XEirYLv8RriNiP29kj4mrFuyPjgXxUvOjskuDzdF8Xd9Yf18gavPn28XS5WuCkpHzGvSdeSslSUtUrXNW1tx8BWVa0aKK1stFSl4IqKUsiuE8ArokRXa93UwkrgF8X7mXu_q7fQNtlBtIO5j25r48EE68y_Fe82pg97oyqhJZUZ8PYEiOFhB2k038Mu-uzZsJLrSjPOJtXVrOrtAMb5LmRYk08LW9cED53L-YXMgyo1PTawuaGJIaUI3ZMlSsy0BWbeApO3wBy3wExNb_7-zFPL75lnAZ8FKZd8D_GP2f9gfwG8vsE2</recordid><startdate>20210201</startdate><enddate>20210201</enddate><creator>Wernhart, Simon</creator><creator>Hedderich, Jürgen</creator><creator>Wunderlich, Svenja</creator><creator>Schauerte, Kunigunde</creator><creator>Weihe, Eberhard</creator><creator>Dellweg, Dominic</creator><creator>Siemon, Karsten</creator><general>Springer International Publishing</general><general>Springer</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>3V.</scope><scope>7RV</scope><scope>7TS</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>KB0</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-6732-0939</orcidid></search><sort><creationdate>20210201</creationdate><title>The Feasibility of High-Intensity Interval Training in Patients with Intensive Care Unit-Acquired Weakness Syndrome Following Long-Term Invasive Ventilation</title><author>Wernhart, Simon ; Hedderich, Jürgen ; Wunderlich, Svenja ; Schauerte, Kunigunde ; Weihe, Eberhard ; Dellweg, Dominic ; Siemon, Karsten</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c513t-3b0fd055712d79bb1daf2ea88b7ce5a6c967543714546ff4e38074fb99cb4a6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Intensive care</topic><topic>Interval training</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original</topic><topic>Original Research Article</topic><topic>Sports Medicine</topic><topic>Ventilators</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wernhart, Simon</creatorcontrib><creatorcontrib>Hedderich, Jürgen</creatorcontrib><creatorcontrib>Wunderlich, Svenja</creatorcontrib><creatorcontrib>Schauerte, Kunigunde</creatorcontrib><creatorcontrib>Weihe, Eberhard</creatorcontrib><creatorcontrib>Dellweg, Dominic</creatorcontrib><creatorcontrib>Siemon, Karsten</creatorcontrib><collection>Springer Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Academic OneFile</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Sports Medicine - Open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wernhart, Simon</au><au>Hedderich, Jürgen</au><au>Wunderlich, Svenja</au><au>Schauerte, Kunigunde</au><au>Weihe, Eberhard</au><au>Dellweg, Dominic</au><au>Siemon, Karsten</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Feasibility of High-Intensity Interval Training in Patients with Intensive Care Unit-Acquired Weakness Syndrome Following Long-Term Invasive Ventilation</atitle><jtitle>Sports Medicine - Open</jtitle><stitle>Sports Med - Open</stitle><addtitle>Sports Med Open</addtitle><date>2021-02-01</date><risdate>2021</risdate><volume>7</volume><issue>1</issue><spage>11</spage><pages>11-</pages><artnum>11</artnum><issn>2199-1170</issn><eissn>2198-9761</eissn><abstract>Background
Intensive care unit-acquired weakness syndrome (ICUAWS) can be a consequence of long-term mechanical ventilation. Despite recommendations of early patient mobilisation, little is known about the feasibility, safety and benefit of interval training in early rehabilitation facilities (ERF) after long-term invasive ventilation.
Methods and Results
We retrospectively analysed two established training protocols of bicycle ergometry in ERF patients after long-term (> 7 days) invasive ventilation (
n
= 46). Patients conducted moderate continuous (MCT,
n
= 24, mean age 70.3 ± 10.1 years) or high-intensity interval training (HIIT,
n
= 22, mean age 63.6 ± 12.6 years). The intensity of training was monitored with the BORG CR10 scale (intense phases ≥ 7/10 and moderate phases ≤ 4/10 points). The primary outcome was improvement (∆-values) of six-minute-walk-test (6 MWT), while the secondary outcomes were improvement of vital capacity (VC
max
), forced expiratory volume in 1 s (FEV
1
), maximal inspiratory pressure (PI
max
) and functional capabilities (functional independence assessment measure, FIM/FAM and Barthel scores) after 3 weeks of training. No adverse events were observed. There was a trend towards a greater improvement of 6 MWT in HIIT than MCT (159.5 ± 64.9 m vs. 120.4 ± 60.4 m;
p
= .057), despite more days of invasive ventilation (39.6 ± 16.8 days vs. 26.8 ± 16.2 days;
p
= .009). VC
max
(∆0.5l ± 0.6 vs. ∆0.5l ± 0.3;
p
= .462), FEV
1
(∆0.2l ± 0.3 vs. ∆0.3l ± 0.2;
p
= .218) PI
max
(∆0.8 ± 1.1 kPa vs. ∆0.7 ± 1.3pts;
p
= .918) and functional status (FIM/FAM: ∆29.0 ± 14.8pts vs. ∆30.9 ± 16.0pts;
p
= .707; Barthel: ∆28.9 ± 16.0 pts vs. ∆25.0 ± 10.5pts;
p
= .341) improved in HIIT and MCT.
Conclusions
We demonstrate the feasibility and safety of HIIT in the early rehabilitation of ICUAWS patients. Larger trials are necessary to find adequate dosage of HIIT in ICUAWS patients.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>33527199</pmid><doi>10.1186/s40798-021-00299-6</doi><orcidid>https://orcid.org/0000-0001-6732-0939</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Sports Medicine - Open, 2021-02, Vol.7 (1), p.11, Article 11 |
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| language | eng |
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| source | Springer Open Access; EZB Free E-Journals; DOAJ Directory of Open Access Journals; SpringerLink (Online service); PubMed Central; PubMed Central Open Access |
| subjects | Intensive care Interval training Medicine Medicine & Public Health Original Original Research Article Sports Medicine Ventilators |
| title | The Feasibility of High-Intensity Interval Training in Patients with Intensive Care Unit-Acquired Weakness Syndrome Following Long-Term Invasive Ventilation |
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