ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer

Pancreatic ductal adenocarcinoma is a lethal disease characterized by late diagnosis, propensity for early metastasis and resistance to chemotherapy. Little is known about the mechanisms that drive innate therapeutic resistance in pancreatic cancer. The ataxia-telangiectasia group D-associated gene...

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Veröffentlicht in:	Genes & development 2021-02, Vol.35 (3-4), p.218-233
Hauptverfasser:	Purohit, Vinee, Wang, Lidong, Yang, Huibin, Li, Jiufeng, Ney, Gina M, Gumkowski, Erica R, Vaidya, Akash J, Wang, Annie, Bhardwaj, Amit, Zhao, Ende, Dolgalev, Igor, Zamperone, Andrea, Abel, Ethan V, Magliano, Marina Pasca Di, Crawford, Howard C, Diolaiti, Daniel, Papagiannakopoulos, Thales Y, Lyssiotis, Costas A, Simeone, Diane M
Format:	Artikel
Sprache:	eng
Schlagworte:	Carcinogenesis - genetics DNA-Binding Proteins - metabolism Drug Resistance, Neoplasm - genetics Humans Kelch-Like ECH-Associated Protein 1 - metabolism NF-E2-Related Factor 2 - metabolism Pancreatic Neoplasms Pancreatic Neoplasms - physiopathology Protein Binding Research Paper Transcription Factors - metabolism
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