Role of monocarboxylate transporters in regulating metabolic homeostasis in the outer retina: Insight gained from cell‐specific Bsg deletion

The neural retina metabolizes glucose through aerobic glycolysis generating large amounts of lactate. Lactate flux into and out of cells is regulated by proton‐coupled monocarboxylate transporters (MCTs), which are encoded by members of the Slc16a family. MCT1, MCT3, and MCT4 are expressed in the re...

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Veröffentlicht in:	The FASEB journal 2020-04, Vol.34 (4), p.5401-5419
Hauptverfasser:	Han, John Y. S., Kinoshita, Junzo, Bisetto, Sara, Bell, Brent A., Nowak, Romana A., Peachey, Neal S., Philp, Nancy J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals basigin Basigin - physiology Biological Transport Homeostasis lactate Lactic Acid - metabolism Mice Mice, Inbred C57BL Mice, Knockout monocarboxylate transporters Monocarboxylic Acid Transporters - metabolism photoreceptors retina Retinal Cone Photoreceptor Cells - metabolism Retinal Pigment Epithelium - metabolism Retinal Rod Photoreceptor Cells - metabolism RPE
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