Toll-like receptor 4 signaling activates ERG function in prostate cancer and provides a therapeutic target

The gene fusion and subsequent overexpression of the ERG transcription factor occurs in ∼50% of prostate tumors, making it the most common abnormality of the prostate cancer genome. While ERG has been shown to drive tumor progression and cancer-related phenotypes, as a transcription factor it is dif...

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Veröffentlicht in:	NAR cancer 2021-03, Vol.3 (1), p.zcaa046
Hauptverfasser:	Greulich, Benjamin M, Plotnik, Joshua P, Jerde, Travis J, Hollenhorst, Peter C
Format:	Artikel
Sprache:	eng
Schlagworte:	Cancer Gene Regulation, Chromatin, and Epigenetics
Online-Zugang:	Volltext
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