Gene therapy for neovascular age-related macular degeneration: rationale, clinical trials and future directions

Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness in the developed world. Antivascular endothelial growth factor therapy has transformed the management and outcome of neovascular AMD (nAMD), although the need for repeated intravitreal injections—even lifel...

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Veröffentlicht in:	British journal of ophthalmology 2021-02, Vol.105 (2), p.151-157
Hauptverfasser:	Guimaraes, Thales Antonio Cabral de, Georgiou, Michalis, Bainbridge, James W B, Michaelides, Michel
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Choroidal Neovascularization - therapy Clinical trials Clinical Trials as Topic Disease Drug dosages Forecasting Gene expression Gene therapy Genetic Therapy - methods Genetic Therapy - trends Humans Macular degeneration Older people Ophthalmology Permeability Physiology Review Vascular endothelial growth factor Vectors (Biology) Wet Macular Degeneration - therapy
Online-Zugang:	Volltext
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