MiR-1254 and MEGF6 regulates oxaliplatin resistance in human colorectal cancer cells
Colorectal cancer (CRC) remains one of the deadliest diseases in the whole world. Cancer recurrence and chemotherapeutic drug resistance limit the overall survival rate of patients with CRC. This study aimed to discover the latent miRNAs and genes associated with oxaliplatin resistance in CRC cells....
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| Veröffentlicht in: | American journal of translational research 2021-01, Vol.13 (1), p.183-196 |
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| container_title | American journal of translational research |
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| creator | Mou, Yueyang He, Nabin Su, Mengyang Zhong, Zihua Ma, Jiayu Liu, Jianling Cheng, Xi'an Dai, Penggao |
| description | Colorectal cancer (CRC) remains one of the deadliest diseases in the whole world. Cancer recurrence and chemotherapeutic drug resistance limit the overall survival rate of patients with CRC. This study aimed to discover the latent miRNAs and genes associated with oxaliplatin resistance in CRC cells. The study found that miR-1254 is upregulated in oxaliplatin-resistant CRC cell line HCT116-R compared with its parental cell line HCT116 by transcriptome sequencing and small RNA sequencing. Meanwhile,
(multiple EGF-like domains 6) was downregulated in HCT116-R cells. Transient transfection of miR-1254 mimics significantly reduced cell apoptosis, increased HCT116 tolerance to oxaliplatin, and enhanced
expression. Furthermore, transfection of miR-1254 inhibitor increased apoptosis, decreased HCT116-R tolerance to oxaliplatin, and reduced
expression. In addition, transient transfection of Si
enhanced HCT116 cell resistance to oxaliplatin and reduced cell apoptosis. In summary,
is a latent functional target of miR-1254 in regulating oxaliplatin resistance and apoptosis in human CRC cells, suggesting a potential therapeutic target for CRC. |
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(multiple EGF-like domains 6) was downregulated in HCT116-R cells. Transient transfection of miR-1254 mimics significantly reduced cell apoptosis, increased HCT116 tolerance to oxaliplatin, and enhanced
expression. Furthermore, transfection of miR-1254 inhibitor increased apoptosis, decreased HCT116-R tolerance to oxaliplatin, and reduced
expression. In addition, transient transfection of Si
enhanced HCT116 cell resistance to oxaliplatin and reduced cell apoptosis. In summary,
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(multiple EGF-like domains 6) was downregulated in HCT116-R cells. Transient transfection of miR-1254 mimics significantly reduced cell apoptosis, increased HCT116 tolerance to oxaliplatin, and enhanced
expression. Furthermore, transfection of miR-1254 inhibitor increased apoptosis, decreased HCT116-R tolerance to oxaliplatin, and reduced
expression. In addition, transient transfection of Si
enhanced HCT116 cell resistance to oxaliplatin and reduced cell apoptosis. In summary,
is a latent functional target of miR-1254 in regulating oxaliplatin resistance and apoptosis in human CRC cells, suggesting a potential therapeutic target for CRC.</description><subject>Original</subject><issn>1943-8141</issn><issn>1943-8141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNpVUF1LwzAUDaK4Of0LkkdfCs1n0xdBxjaFDUHmc0jSdIukSW1a0X9vh1Pm0z3nnss5nHsGpqikJBOIovMTPAFXKb3lOWclx5dgQgjDRY6KKdhu3EuGMKNQhQpuFqslh53dDV71NsH4qbxrR-zCuE0u9SoYC0e2HxoVoIk-dtb0ykNzUDporPfpGlzUyid7c5wz8LpcbOeP2fp59TR_WGct5rzPFLeV5lZoU-pS14hURmGDMCWkFKWgrOJC8AMVHBmNuKbUkroWStekYJzMwP2PbzvoxlbGhr5TXrada1T3JaNy8r8S3F7u4ocsBC0YQqPB3dGgi--DTb1sXDpUUMHGIUlMBWM455iNp7enWX8hv68k38XdcTY</recordid><startdate>20210101</startdate><enddate>20210101</enddate><creator>Mou, Yueyang</creator><creator>He, Nabin</creator><creator>Su, Mengyang</creator><creator>Zhong, Zihua</creator><creator>Ma, Jiayu</creator><creator>Liu, Jianling</creator><creator>Cheng, Xi'an</creator><creator>Dai, Penggao</creator><general>e-Century Publishing Corporation</general><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210101</creationdate><title>MiR-1254 and MEGF6 regulates oxaliplatin resistance in human colorectal cancer cells</title><author>Mou, Yueyang ; He, Nabin ; Su, Mengyang ; Zhong, Zihua ; Ma, Jiayu ; Liu, Jianling ; Cheng, Xi'an ; Dai, Penggao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p266t-a6edb6e8bc9b9bf13dca2c12433989845d68862433861cb16b44e3ff8abf37563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Original</topic><toplevel>online_resources</toplevel><creatorcontrib>Mou, Yueyang</creatorcontrib><creatorcontrib>He, Nabin</creatorcontrib><creatorcontrib>Su, Mengyang</creatorcontrib><creatorcontrib>Zhong, Zihua</creatorcontrib><creatorcontrib>Ma, Jiayu</creatorcontrib><creatorcontrib>Liu, Jianling</creatorcontrib><creatorcontrib>Cheng, Xi'an</creatorcontrib><creatorcontrib>Dai, Penggao</creatorcontrib><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>American journal of translational research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mou, Yueyang</au><au>He, Nabin</au><au>Su, Mengyang</au><au>Zhong, Zihua</au><au>Ma, Jiayu</au><au>Liu, Jianling</au><au>Cheng, Xi'an</au><au>Dai, Penggao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>MiR-1254 and MEGF6 regulates oxaliplatin resistance in human colorectal cancer cells</atitle><jtitle>American journal of translational research</jtitle><addtitle>Am J Transl Res</addtitle><date>2021-01-01</date><risdate>2021</risdate><volume>13</volume><issue>1</issue><spage>183</spage><epage>196</epage><pages>183-196</pages><issn>1943-8141</issn><eissn>1943-8141</eissn><abstract>Colorectal cancer (CRC) remains one of the deadliest diseases in the whole world. Cancer recurrence and chemotherapeutic drug resistance limit the overall survival rate of patients with CRC. This study aimed to discover the latent miRNAs and genes associated with oxaliplatin resistance in CRC cells. The study found that miR-1254 is upregulated in oxaliplatin-resistant CRC cell line HCT116-R compared with its parental cell line HCT116 by transcriptome sequencing and small RNA sequencing. Meanwhile,
(multiple EGF-like domains 6) was downregulated in HCT116-R cells. Transient transfection of miR-1254 mimics significantly reduced cell apoptosis, increased HCT116 tolerance to oxaliplatin, and enhanced
expression. Furthermore, transfection of miR-1254 inhibitor increased apoptosis, decreased HCT116-R tolerance to oxaliplatin, and reduced
expression. In addition, transient transfection of Si
enhanced HCT116 cell resistance to oxaliplatin and reduced cell apoptosis. In summary,
is a latent functional target of miR-1254 in regulating oxaliplatin resistance and apoptosis in human CRC cells, suggesting a potential therapeutic target for CRC.</abstract><cop>United States</cop><pub>e-Century Publishing Corporation</pub><pmid>33527017</pmid><tpages>14</tpages></addata></record> |
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| title | MiR-1254 and MEGF6 regulates oxaliplatin resistance in human colorectal cancer cells |
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