Genomic monitoring of SARS-CoV-2 uncovers an Nsp1 deletion variant that modulates type I interferon response

The SARS-CoV-2 virus, the causative agent of COVID-19, is undergoing constant mutation. Here, we utilized an integrative approach combining epidemiology, virus genome sequencing, clinical phenotyping, and experimental validation to locate mutations of clinical importance. We identified 35 recurrent...

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Veröffentlicht in:	Cell host & microbe 2021-03, Vol.29 (3), p.489-502.e8
Hauptverfasser:	Lin, Jing-wen, Tang, Chao, Wei, Han-cheng, Du, Baowen, Chen, Chuan, Wang, Minjin, Zhou, Yongzhao, Yu, Ming-xia, Cheng, Lu, Kuivanen, Suvi, Ogando, Natacha S., Levanov, Lev, Zhao, Yuancun, Li, Chang-ling, Zhou, Ran, Li, Zhidan, Zhang, Yiming, Sun, Ke, Wang, Chengdi, Chen, Li, Xiao, Xia, Zheng, Xiuran, Chen, Sha-sha, Zhou, Zhen, Yang, Ruirui, Zhang, Dan, Xu, Mengying, Song, Junwei, Wang, Danrui, Li, Yupeng, Lei, ShiKun, Zeng, Wanqin, Yang, Qingxin, He, Ping, Zhang, Yaoyao, Zhou, Lifang, Cao, Ling, Luo, Feng, Liu, Huayi, Wang, Liping, Ye, Fei, Zhang, Ming, Li, Mengjiao, Fan, Wei, Li, Xinqiong, Li, Kaiju, Ke, Bowen, Xu, Jiannan, Yang, Huiping, He, Shusen, Pan, Ming, Yan, Yichen, Zha, Yi, Jiang, Lingyu, Yu, Changxiu, Liu, Yingfen, Xu, Zhiyong, Li, Qingfeng, Jiang, Yongmei, Sun, Jiufeng, Hong, Wei, Wei, Hongping, Lu, Guangwen, Vapalahti, Olli, Luo, Yunzi, Wei, Yuquan, Connor, Thomas, Tan, Wenjie, Snijder, Eric J., Smura, Teemu, Li, Weimin, Geng, Jia, Ying, Binwu, Chen, Lu
Format:	Artikel
Sprache:	eng
Schlagworte:	A549 Cells Adolescent Adult Aged Aged, 80 and over Animals association Base Sequence Cell Line Child Child, Preschool Chlorocebus aethiops clinical phenotype COVID-19 COVID-19 - blood COVID-19 - immunology COVID-19 - virology deletion Female Gene Deletion genetic variants genomic epidemiology Genomics HEK293 Cells Humans Infant interferon Interferon Type I - blood Interferon Type I - immunology Interferon-beta - blood Interferon-beta - metabolism Male Middle Aged Molecular Epidemiology Nsp1 Reverse Genetics SARS-CoV-2 SARS-CoV-2 - genetics SARS-CoV-2 - immunology Vero Cells Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - immunology Young Adult
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