Antigen-driven clonal selection shapes the persistence of HIV-1-infected CD4+ T cells in vivo

Clonal expansion of infected CD4+ T cells is a major mechanism of HIV-1 persistence and a barrier to achieving a cure. Potential causes are homeostatic proliferation, effects of HIV-1 integration, and interaction with antigens. Here, we show that it is possible to link antigen responsiveness, the fu...

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Veröffentlicht in:	The Journal of clinical investigation 2021-02, Vol.131 (3)
Hauptverfasser:	Simonetti, Francesco R, Zhang, Hao, Soroosh, Garshasb P, Duan, Jiayi, Rhodehouse, Kyle, Hill, Alison L, Beg, Subul A, McCormick, Kevin, Raymond, Hayley E, Nobles, Christopher L, Everett, John K, Kwon, Kyungyoon J, White, Jennifer A, Lai, Jun, Margolick, Joseph B, Hoh, Rebecca, Deeks, Steven G, Bushman, Frederic D, Siliciano, Janet D, Siliciano, Robert F
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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