Methyltransferase inhibitors restore SATB1 protective activity against cutaneous T cell lymphoma in mice

Cutaneous T cell lymphoma (CTCL) has a poorly understood etiology and no known cure. Using conditional knockout mice, we found that ablation of the genomic organizer special AT-rich sequence-binding protein 1 (Satb1) caused malignant transformation of mature, skin-homing, Notch-activated CD4+ and CD...

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Veröffentlicht in:	The Journal of clinical investigation 2021-02, Vol.131 (3)
Hauptverfasser:	Harro, Carly M, Perez-Sanz, Jairo, Costich, Tara Lee, Payne, Kyle K, Anadon, Carmen M, Chaurio, Ricardo A, Biswas, Subir, Mandal, Gunjan, Rigolizzo, Kristen E, Sprenger, Kimberly B, Mine, Jessica A, Showe, Louise C, Yu, Xiaoqing, Liu, Kebin, Rodriguez, Paulo C, Pinilla-Ibarz, Javier, Sokol, Lubomir, Conejo-Garcia, Jose R
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals CD4-Positive T-Lymphocytes - metabolism CD4-Positive T-Lymphocytes - pathology CD8-Positive T-Lymphocytes - metabolism CD8-Positive T-Lymphocytes - pathology Cell Line, Tumor Development and progression Enzyme inhibitors Enzyme Inhibitors - pharmacology Genetic aspects Health aspects Humans Matrix Attachment Region Binding Proteins - metabolism Methyltransferases Methyltransferases - antagonists & inhibitors Methyltransferases - metabolism Mice Mice, Transgenic Neoplasm Proteins - antagonists & inhibitors Neoplasm Proteins - metabolism Physiological aspects Sezary Syndrome - drug therapy Sezary Syndrome - metabolism Sezary Syndrome - pathology Skin Neoplasms - drug therapy Skin Neoplasms - metabolism Skin Neoplasms - pathology T cell lymphoma Transcription factors
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