Recent advances in nanomaterials based biosensors for point of care (PoC) diagnosis of Covid-19 – A minireview
Early diagnosis and ultrahigh sample throughput screening are the need of the hour to control the geological spread of the COVID-19 pandemic. Traditional laboratory tests such as enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) and computed tomograp...
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description | Early diagnosis and ultrahigh sample throughput screening are the need of the hour to control the geological spread of the COVID-19 pandemic. Traditional laboratory tests such as enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) and computed tomography are implemented for the detection of COVID-19. However, they are limited by the laborious sample collection and processing procedures, longer wait time for test results and skilled technicians to operate sophisticated facilities. In this context, the point of care (PoC) diagnostic platform has proven to be the prospective approach in addressing the abovementioned challenges. This review emphasizes the mechanism of viral infection spread detailing the host-virus interaction, pathophysiology, and the recent advances in the development of affordable PoC diagnostic platforms for rapid and accurate diagnosis of COVID-19. First, the well-established optical and electrochemical biosensors are discussed. Subsequently, the recent advances in the development of PoC biosensors, including lateral flow immunoassays and other emerging techniques, are highlighted. Finally, a focus on integrating nanotechnology with wearables and smartphones to develop smart nanobiosensors is outlined, which could promote COVID-19 diagnosis accessible to both individuals and the mass population at patient care.
[Display omitted]
•Emphasizing the huge demand for affordable point of care diagnostic tools to control the global COVID-19 pandemic.•Highlighting the recent advances in the development of PoC based optical and electrochemical biosensors.•Reviewed the application of wearables and smart nanobiosensors for real time monitoring of COVID-19. |
doi_str_mv | 10.1016/j.trac.2021.116205 |
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[Display omitted]
•Emphasizing the huge demand for affordable point of care diagnostic tools to control the global COVID-19 pandemic.•Highlighting the recent advances in the development of PoC based optical and electrochemical biosensors.•Reviewed the application of wearables and smart nanobiosensors for real time monitoring of COVID-19.</description><identifier>ISSN: 0165-9936</identifier><identifier>EISSN: 1879-3142</identifier><identifier>DOI: 10.1016/j.trac.2021.116205</identifier><identifier>PMID: 33531721</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>COVID-19 diagnosis ; Electrochemical biosensors ; Nanoparticles ; Optical biosensors ; Smart nanobiosensors ; Wearable biosensors</subject><ispartof>TrAC, Trends in analytical chemistry (Regular ed.), 2021-04, Vol.137, p.116205-116205, Article 116205</ispartof><rights>2021 Elsevier B.V.</rights><rights>2021 Elsevier B.V. All rights reserved.</rights><rights>2021 Elsevier B.V. All rights reserved. 2021 Elsevier B.V.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-2bbe428f80bb025f19250e76db44529df3afa00dba858f2b948bcc5e9c71538d3</citedby><cites>FETCH-LOGICAL-c455t-2bbe428f80bb025f19250e76db44529df3afa00dba858f2b948bcc5e9c71538d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.trac.2021.116205$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,780,784,885,3548,27923,27924,45994</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33531721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gowri, Annasamy</creatorcontrib><creatorcontrib>Ashwin Kumar, N.</creatorcontrib><creatorcontrib>Suresh Anand, B.S.</creatorcontrib><title>Recent advances in nanomaterials based biosensors for point of care (PoC) diagnosis of Covid-19 – A minireview</title><title>TrAC, Trends in analytical chemistry (Regular ed.)</title><addtitle>Trends Analyt Chem</addtitle><description>Early diagnosis and ultrahigh sample throughput screening are the need of the hour to control the geological spread of the COVID-19 pandemic. Traditional laboratory tests such as enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) and computed tomography are implemented for the detection of COVID-19. However, they are limited by the laborious sample collection and processing procedures, longer wait time for test results and skilled technicians to operate sophisticated facilities. In this context, the point of care (PoC) diagnostic platform has proven to be the prospective approach in addressing the abovementioned challenges. This review emphasizes the mechanism of viral infection spread detailing the host-virus interaction, pathophysiology, and the recent advances in the development of affordable PoC diagnostic platforms for rapid and accurate diagnosis of COVID-19. First, the well-established optical and electrochemical biosensors are discussed. Subsequently, the recent advances in the development of PoC biosensors, including lateral flow immunoassays and other emerging techniques, are highlighted. Finally, a focus on integrating nanotechnology with wearables and smartphones to develop smart nanobiosensors is outlined, which could promote COVID-19 diagnosis accessible to both individuals and the mass population at patient care.
[Display omitted]
•Emphasizing the huge demand for affordable point of care diagnostic tools to control the global COVID-19 pandemic.•Highlighting the recent advances in the development of PoC based optical and electrochemical biosensors.•Reviewed the application of wearables and smart nanobiosensors for real time monitoring of COVID-19.</description><subject>COVID-19 diagnosis</subject><subject>Electrochemical biosensors</subject><subject>Nanoparticles</subject><subject>Optical biosensors</subject><subject>Smart nanobiosensors</subject><subject>Wearable biosensors</subject><issn>0165-9936</issn><issn>1879-3142</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><recordid>eNp9kc2KFDEUhYMoTjv6Ai4ky3FRbX4qVQmIMDT-wYAiug75uRnTdCVtUt2DO9_BN_RJTNHjoBtXgeScc2_Oh9BTStaU0OHFdj0X49aMMLqmdGBE3EMrKkfVcdqz-2jVRKJTig9n6FGtW0LIQIh6iM44F5yOjK7Q_hM4SDM2_miSg4pjwsmkPJkZSjS7iq2p4LGNuUKquVQccsH7HJspB-xMAXzxMW-eYx_Ndco11uV-k4_Rd1ThXz9-4ks8xRQLHCPcPEYPQouFJ7fnOfry5vXnzbvu6sPb95vLq871QswdsxZ6JoMk1hImAlVMEBgHb_teMOUDN8EQ4q2RQgZmVS-tcwKUG6ng0vNz9OqUuz_YCfzyyWJ2el_iZMp3nU3U_76k-FVf56MeZc-o4i3g4jag5G8HqLOeYnWw25kE-VA162UbRalgTcpOUldyrQXC3RhK9IJKb_WCSi-o9AlVMz37e8E7yx82TfDyJIBWU6uu6OoiNEi-Velm7XP8X_5vsCGnFw</recordid><startdate>20210401</startdate><enddate>20210401</enddate><creator>Gowri, Annasamy</creator><creator>Ashwin Kumar, N.</creator><creator>Suresh Anand, B.S.</creator><general>Elsevier B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210401</creationdate><title>Recent advances in nanomaterials based biosensors for point of care (PoC) diagnosis of Covid-19 – A minireview</title><author>Gowri, Annasamy ; Ashwin Kumar, N. ; Suresh Anand, B.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-2bbe428f80bb025f19250e76db44529df3afa00dba858f2b948bcc5e9c71538d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>COVID-19 diagnosis</topic><topic>Electrochemical biosensors</topic><topic>Nanoparticles</topic><topic>Optical biosensors</topic><topic>Smart nanobiosensors</topic><topic>Wearable biosensors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gowri, Annasamy</creatorcontrib><creatorcontrib>Ashwin Kumar, N.</creatorcontrib><creatorcontrib>Suresh Anand, B.S.</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>TrAC, Trends in analytical chemistry (Regular ed.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gowri, Annasamy</au><au>Ashwin Kumar, N.</au><au>Suresh Anand, B.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recent advances in nanomaterials based biosensors for point of care (PoC) diagnosis of Covid-19 – A minireview</atitle><jtitle>TrAC, Trends in analytical chemistry (Regular ed.)</jtitle><addtitle>Trends Analyt Chem</addtitle><date>2021-04-01</date><risdate>2021</risdate><volume>137</volume><spage>116205</spage><epage>116205</epage><pages>116205-116205</pages><artnum>116205</artnum><issn>0165-9936</issn><eissn>1879-3142</eissn><abstract>Early diagnosis and ultrahigh sample throughput screening are the need of the hour to control the geological spread of the COVID-19 pandemic. Traditional laboratory tests such as enzyme-linked immunosorbent assay (ELISA), reverse transcription polymerase chain reaction (RT-PCR) and computed tomography are implemented for the detection of COVID-19. However, they are limited by the laborious sample collection and processing procedures, longer wait time for test results and skilled technicians to operate sophisticated facilities. In this context, the point of care (PoC) diagnostic platform has proven to be the prospective approach in addressing the abovementioned challenges. This review emphasizes the mechanism of viral infection spread detailing the host-virus interaction, pathophysiology, and the recent advances in the development of affordable PoC diagnostic platforms for rapid and accurate diagnosis of COVID-19. First, the well-established optical and electrochemical biosensors are discussed. Subsequently, the recent advances in the development of PoC biosensors, including lateral flow immunoassays and other emerging techniques, are highlighted. Finally, a focus on integrating nanotechnology with wearables and smartphones to develop smart nanobiosensors is outlined, which could promote COVID-19 diagnosis accessible to both individuals and the mass population at patient care.
[Display omitted]
•Emphasizing the huge demand for affordable point of care diagnostic tools to control the global COVID-19 pandemic.•Highlighting the recent advances in the development of PoC based optical and electrochemical biosensors.•Reviewed the application of wearables and smart nanobiosensors for real time monitoring of COVID-19.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>33531721</pmid><doi>10.1016/j.trac.2021.116205</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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source | ScienceDirect Journals (5 years ago - present) |
subjects | COVID-19 diagnosis Electrochemical biosensors Nanoparticles Optical biosensors Smart nanobiosensors Wearable biosensors |
title | Recent advances in nanomaterials based biosensors for point of care (PoC) diagnosis of Covid-19 – A minireview |
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