Nasopharyngeal carcinoma metastasis to the breast
Breast metastases from extra-mammary neoplasms are rare, accounting for less than 2% of breast cancer cases. A 43-year-old female patient presented with a mass in her left breast and swelling in her left axillary region. A histopathological examination of the mass showed enlarged polygonal tumor cel...
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| Veröffentlicht in: | Saudi medical journal 2020-10, Vol.41 (10), p.1130-1134 |
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| description | Breast metastases from extra-mammary neoplasms are rare, accounting for less than 2% of breast cancer cases. A 43-year-old female patient presented with a mass in her left breast and swelling in her left axillary region. A histopathological examination of the mass showed enlarged polygonal tumor cells with scant to moderate, eosinophilic to amphophilic cytoplasm and enlarged, hyperchromatic and pleomorphic nuclei with irregular nuclear membranes. An immunohistochemistry (IHC) examination was positive for pan cytokeratin and negative for CK7, CK20, S-100, LCA, HMB45, CD 20, desmin, myogenin, GCFDP-15, transcription factor-1, villin, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. As she was a known case of nasopharyngeal carcinoma, and based on the histopathology ndings and IHC profile, the patient was diagnosed with breast metastasis from NPC. The patient was deceased 3 months after refusing the recommended medical intervention. |
| doi_str_mv | 10.15537/smj.2020.10.25420 |
| format | Article |
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A 43-year-old female patient presented with a mass in her left breast and swelling in her left axillary region. A histopathological examination of the mass showed enlarged polygonal tumor cells with scant to moderate, eosinophilic to amphophilic cytoplasm and enlarged, hyperchromatic and pleomorphic nuclei with irregular nuclear membranes. An immunohistochemistry (IHC) examination was positive for pan cytokeratin and negative for CK7, CK20, S-100, LCA, HMB45, CD 20, desmin, myogenin, GCFDP-15, transcription factor-1, villin, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. As she was a known case of nasopharyngeal carcinoma, and based on the histopathology ndings and IHC profile, the patient was diagnosed with breast metastasis from NPC. The patient was deceased 3 months after refusing the recommended medical intervention.</description><identifier>ISSN: 0379-5284</identifier><identifier>EISSN: 1658-3175</identifier><identifier>DOI: 10.15537/smj.2020.10.25420</identifier><identifier>PMID: 33026055</identifier><language>eng</language><publisher>Saudi Arabia: Saudi Medical Journal</publisher><subject>Adult ; Biomarkers, Tumor - analysis ; Breast cancer ; Breast Neoplasms - diagnosis ; Breast Neoplasms - pathology ; Breast Neoplasms - secondary ; Breast Neoplasms - therapy ; Cancer metastasis ; Carcinoma ; Case Report ; Case reports ; Diagnosis, Differential ; Epidermal growth factors ; Estrogens ; Female ; Head & neck cancer ; Health aspects ; Humans ; Immunohistochemistry ; Keratin ; Keratins - analysis ; Medical diagnosis ; Medical research ; Metastasis ; Nasopharyngeal Carcinoma - diagnosis ; Nasopharyngeal Carcinoma - pathology ; Nasopharyngeal Carcinoma - secondary ; Nasopharyngeal Carcinoma - therapy ; Nasopharyngeal Neoplasms - pathology ; Progesterone ; Rare Diseases ; Saudi Arabia ; Throat cancer ; Tumors ; Women's health</subject><ispartof>Saudi medical journal, 2020-10, Vol.41 (10), p.1130-1134</ispartof><rights>COPYRIGHT 2020 Saudi Medical Journal</rights><rights>Saudi Medical Journal 2020. This work is licensed under the Creative Commons Attribution – Non-Commercial License http://creativecommons.org/licenses/by-nc/3.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Copyright: © Saudi Medical Journal 2020</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c497t-e5fe7e74db886137b0f482683e90d91a9494f32e40424cc524f3e232aac3bb543</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841513/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841513/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33026055$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Albasri, Abdulkader M</creatorcontrib><title>Nasopharyngeal carcinoma metastasis to the breast</title><title>Saudi medical journal</title><addtitle>Saudi Med J</addtitle><description>Breast metastases from extra-mammary neoplasms are rare, accounting for less than 2% of breast cancer cases. A 43-year-old female patient presented with a mass in her left breast and swelling in her left axillary region. A histopathological examination of the mass showed enlarged polygonal tumor cells with scant to moderate, eosinophilic to amphophilic cytoplasm and enlarged, hyperchromatic and pleomorphic nuclei with irregular nuclear membranes. An immunohistochemistry (IHC) examination was positive for pan cytokeratin and negative for CK7, CK20, S-100, LCA, HMB45, CD 20, desmin, myogenin, GCFDP-15, transcription factor-1, villin, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. As she was a known case of nasopharyngeal carcinoma, and based on the histopathology ndings and IHC profile, the patient was diagnosed with breast metastasis from NPC. The patient was deceased 3 months after refusing the recommended medical intervention.</description><subject>Adult</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Breast cancer</subject><subject>Breast Neoplasms - diagnosis</subject><subject>Breast Neoplasms - pathology</subject><subject>Breast Neoplasms - secondary</subject><subject>Breast Neoplasms - therapy</subject><subject>Cancer metastasis</subject><subject>Carcinoma</subject><subject>Case Report</subject><subject>Case reports</subject><subject>Diagnosis, Differential</subject><subject>Epidermal growth factors</subject><subject>Estrogens</subject><subject>Female</subject><subject>Head & neck cancer</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Keratin</subject><subject>Keratins - analysis</subject><subject>Medical diagnosis</subject><subject>Medical research</subject><subject>Metastasis</subject><subject>Nasopharyngeal Carcinoma - diagnosis</subject><subject>Nasopharyngeal Carcinoma - pathology</subject><subject>Nasopharyngeal Carcinoma - secondary</subject><subject>Nasopharyngeal Carcinoma - therapy</subject><subject>Nasopharyngeal Neoplasms - pathology</subject><subject>Progesterone</subject><subject>Rare Diseases</subject><subject>Saudi Arabia</subject><subject>Throat cancer</subject><subject>Tumors</subject><subject>Women's health</subject><issn>0379-5284</issn><issn>1658-3175</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptUU2PFCEQJUbjjqt_wIPpxIuXHqEKGriYbDZ-JRu96JnQTPUMk-5mhJ5N_Pcyu-vqGgMJqcd7rygeYy8FXwulUL8t034NHGrJ16Ak8EdsJTplWhRaPWYrjtq2Cow8Y89K2XOOXce7p-wMkUPHlVox8cWXdNj5_HPekh-b4HOIc5p8M9HiS92xNEtqlh01faaKPGdPBj8WenF3nrPvH95_u_zUXn39-Pny4qoN0uqlJTWQJi03vTGdQN3zQRroDJLlGyu8lVYOCCS5BBmCgloRIHgfsO-VxHP27tb3cOwn2gSal-xHd8hxqq91yUf38GaOO7dN104bKZTAavDmziCnH0cqi5tiCTSOfqZ0LA6ktMIAClupr_-h7tMxz3W8yrIWlEaOf1hbP5KL85Bq33AydRcdGm0FaKis9X9YdW1oiiHNNMSKPxDArSDkVEqm4X5Gwd1N0K4G7U5Bn5CboKvo1d-_cy_5nSz-AvxAoiw</recordid><startdate>20201001</startdate><enddate>20201001</enddate><creator>Albasri, Abdulkader M</creator><general>Saudi Medical Journal</general><general>Prince Sultan Military Medical City (PSMMC)</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201001</creationdate><title>Nasopharyngeal carcinoma metastasis to the breast</title><author>Albasri, Abdulkader M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c497t-e5fe7e74db886137b0f482683e90d91a9494f32e40424cc524f3e232aac3bb543</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Breast cancer</topic><topic>Breast Neoplasms - diagnosis</topic><topic>Breast Neoplasms - pathology</topic><topic>Breast Neoplasms - secondary</topic><topic>Breast Neoplasms - therapy</topic><topic>Cancer metastasis</topic><topic>Carcinoma</topic><topic>Case Report</topic><topic>Case reports</topic><topic>Diagnosis, Differential</topic><topic>Epidermal growth factors</topic><topic>Estrogens</topic><topic>Female</topic><topic>Head & neck cancer</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Keratin</topic><topic>Keratins - analysis</topic><topic>Medical diagnosis</topic><topic>Medical research</topic><topic>Metastasis</topic><topic>Nasopharyngeal Carcinoma - diagnosis</topic><topic>Nasopharyngeal Carcinoma - pathology</topic><topic>Nasopharyngeal Carcinoma - secondary</topic><topic>Nasopharyngeal Carcinoma - therapy</topic><topic>Nasopharyngeal Neoplasms - pathology</topic><topic>Progesterone</topic><topic>Rare Diseases</topic><topic>Saudi Arabia</topic><topic>Throat cancer</topic><topic>Tumors</topic><topic>Women's health</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Albasri, Abdulkader M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - 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A 43-year-old female patient presented with a mass in her left breast and swelling in her left axillary region. A histopathological examination of the mass showed enlarged polygonal tumor cells with scant to moderate, eosinophilic to amphophilic cytoplasm and enlarged, hyperchromatic and pleomorphic nuclei with irregular nuclear membranes. An immunohistochemistry (IHC) examination was positive for pan cytokeratin and negative for CK7, CK20, S-100, LCA, HMB45, CD 20, desmin, myogenin, GCFDP-15, transcription factor-1, villin, estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. As she was a known case of nasopharyngeal carcinoma, and based on the histopathology ndings and IHC profile, the patient was diagnosed with breast metastasis from NPC. 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| subjects | Adult Biomarkers, Tumor - analysis Breast cancer Breast Neoplasms - diagnosis Breast Neoplasms - pathology Breast Neoplasms - secondary Breast Neoplasms - therapy Cancer metastasis Carcinoma Case Report Case reports Diagnosis, Differential Epidermal growth factors Estrogens Female Head & neck cancer Health aspects Humans Immunohistochemistry Keratin Keratins - analysis Medical diagnosis Medical research Metastasis Nasopharyngeal Carcinoma - diagnosis Nasopharyngeal Carcinoma - pathology Nasopharyngeal Carcinoma - secondary Nasopharyngeal Carcinoma - therapy Nasopharyngeal Neoplasms - pathology Progesterone Rare Diseases Saudi Arabia Throat cancer Tumors Women's health |
| title | Nasopharyngeal carcinoma metastasis to the breast |
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