Knockdown of Latent Transforming Growth Factor-β (TGF-β)-Binding Protein 2 (LTBP2) Inhibits Invasion and Tumorigenesis in Thyroid Carcinoma Cells

Latent transforming growth factor-β (TGF-β)-binding protein 2 (LTBP2) is one of four proteins in the LTBP family of proteins (LTBP1-4) and was shown to play a vital role in tumorigenesis. However, little is known regarding the functional role of LTBP2 in thyroid carcinoma. Therefore, the current stu...

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Veröffentlicht in:	Oncology research 2017-04, Vol.25 (4), p.503-510
Hauptverfasser:	Wan, Fuqiang, Peng, Li, Zhu, ChaoYu, Zhang, XinFa, Chen, FangWen, Liu, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Line, Tumor Cell Movement - genetics Cell Proliferation Cell Transformation, Neoplastic - genetics Cell Transformation, Neoplastic - metabolism Disease Models, Animal Epithelial-Mesenchymal Transition - genetics Gene Expression Gene Knockdown Techniques Heterografts Humans Invasion Latent TGF-beta Binding Proteins - genetics Latent transforming growth factor-β (TGF-β)-binding protein 2 (LTBP2) Mice Neoplasm Invasiveness Phosphatidylinositol 3-Kinases - metabolism Pi3k/akt Pathway Proto-Oncogene Proteins c-akt - metabolism Signal Transduction Thyroid Carcinoma Thyroid Neoplasms - genetics Thyroid Neoplasms - metabolism Thyroid Neoplasms - pathology
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