miR-181a Inhibits Cervical Cancer Development via Downregulating GRP78
Cervical cancer is among the most common cancers inflicting women worldwide. Understanding the pathological mechanisms of cervical cancer development is critical for identifying novel targets for cervical cancer treatment. MicroRNAs (miRs) have various roles in regulating cancer development. In this...
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| Veröffentlicht in: | Oncology research 2017-09, Vol.25 (8), p.1341-1348 |
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| creator | Luo, Chengyan Qiu, Jiangnan |
| description | Cervical cancer is among the most common cancers inflicting women worldwide. Understanding the pathological mechanisms of cervical cancer development is critical for identifying novel targets for cervical cancer treatment. MicroRNAs (miRs) have various roles in regulating cancer development.
In this study, we investigated the potential role of miR-181a and its target in regulating cervical cancer development and chemotherapy resistance. The expression of miR-181a was evaluated and modulated in several human cervical cancer cell lines. The role of miR-181a in regulating cervical
cancer growth and chemotherapy sensitivity was investigated in cell culture models and mouse tumor xenograft models. The target of miR-181a and its function were identified in cervical cancer models. We found a distinct expression profile for miR-181a in cervical cancer cell lines. Low expression
of miR-181a was closely related to cervical cancer growth and oxaliplatin resistance. HSPA5/GRP78 was identified as a target of miR-181a in cervical cancer cells. Upregulation of GRP78 led to a high cell proliferation rate and oxaliplatin resistance in cervical cancer models. In a retrospective
cervical cancer cohort, high GRP78 expression was correlated with poor survival. miR-181a suppressed cervical cancer development via downregulating GRP78. High expression of GRP78 is a tumor-promoting factor in cervical cancer and is thus a potential target for novel treatment. |
| doi_str_mv | 10.3727/096504017X14867268787969 |
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In this study, we investigated the potential role of miR-181a and its target in regulating cervical cancer development and chemotherapy resistance. The expression of miR-181a was evaluated and modulated in several human cervical cancer cell lines. The role of miR-181a in regulating cervical
cancer growth and chemotherapy sensitivity was investigated in cell culture models and mouse tumor xenograft models. The target of miR-181a and its function were identified in cervical cancer models. We found a distinct expression profile for miR-181a in cervical cancer cell lines. Low expression
of miR-181a was closely related to cervical cancer growth and oxaliplatin resistance. HSPA5/GRP78 was identified as a target of miR-181a in cervical cancer cells. Upregulation of GRP78 led to a high cell proliferation rate and oxaliplatin resistance in cervical cancer models. In a retrospective
cervical cancer cohort, high GRP78 expression was correlated with poor survival. miR-181a suppressed cervical cancer development via downregulating GRP78. High expression of GRP78 is a tumor-promoting factor in cervical cancer and is thus a potential target for novel treatment.</description><identifier>ISSN: 0965-0407</identifier><identifier>EISSN: 1555-3906</identifier><identifier>DOI: 10.3727/096504017X14867268787969</identifier><identifier>PMID: 28245171</identifier><language>eng</language><publisher>Elmsford, NY: Cognizant Communication Corporation</publisher><subject>Animals ; Cell Line, Tumor ; Cervical Cancer ; Disease Models, Animal ; Down-Regulation ; Female ; Glucose-Regulated Protein 78 (grp78) ; Heat-Shock Proteins - genetics ; Heat-Shock Proteins - metabolism ; HeLa Cells ; Heterografts ; Humans ; Mice ; Mice, Nude ; Microrna-181a ; MicroRNAs - genetics ; MicroRNAs - metabolism ; Oxaliplatin ; Transfection ; Tumor Development ; Uterine Cervical Neoplasms - genetics ; Uterine Cervical Neoplasms - metabolism</subject><ispartof>Oncology research, 2017-09, Vol.25 (8), p.1341-1348</ispartof><rights>Copyright © 2017 Cognizant, LLC. 2017</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-9eff276a0be06fb80148c7774931bb30b9795ce8c2cba350bafc851334e7c8ec3</citedby><cites>FETCH-LOGICAL-c546t-9eff276a0be06fb80148c7774931bb30b9795ce8c2cba350bafc851334e7c8ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841036/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7841036/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,288,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28245171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Luo, Chengyan</creatorcontrib><creatorcontrib>Qiu, Jiangnan</creatorcontrib><title>miR-181a Inhibits Cervical Cancer Development via Downregulating GRP78</title><title>Oncology research</title><addtitle>Oncol Res</addtitle><description>Cervical cancer is among the most common cancers inflicting women worldwide. Understanding the pathological mechanisms of cervical cancer development is critical for identifying novel targets for cervical cancer treatment. MicroRNAs (miRs) have various roles in regulating cancer development.
In this study, we investigated the potential role of miR-181a and its target in regulating cervical cancer development and chemotherapy resistance. The expression of miR-181a was evaluated and modulated in several human cervical cancer cell lines. The role of miR-181a in regulating cervical
cancer growth and chemotherapy sensitivity was investigated in cell culture models and mouse tumor xenograft models. The target of miR-181a and its function were identified in cervical cancer models. We found a distinct expression profile for miR-181a in cervical cancer cell lines. Low expression
of miR-181a was closely related to cervical cancer growth and oxaliplatin resistance. HSPA5/GRP78 was identified as a target of miR-181a in cervical cancer cells. Upregulation of GRP78 led to a high cell proliferation rate and oxaliplatin resistance in cervical cancer models. In a retrospective
cervical cancer cohort, high GRP78 expression was correlated with poor survival. miR-181a suppressed cervical cancer development via downregulating GRP78. High expression of GRP78 is a tumor-promoting factor in cervical cancer and is thus a potential target for novel treatment.</description><subject>Animals</subject><subject>Cell Line, Tumor</subject><subject>Cervical Cancer</subject><subject>Disease Models, Animal</subject><subject>Down-Regulation</subject><subject>Female</subject><subject>Glucose-Regulated Protein 78 (grp78)</subject><subject>Heat-Shock Proteins - genetics</subject><subject>Heat-Shock Proteins - metabolism</subject><subject>HeLa Cells</subject><subject>Heterografts</subject><subject>Humans</subject><subject>Mice</subject><subject>Mice, Nude</subject><subject>Microrna-181a</subject><subject>MicroRNAs - genetics</subject><subject>MicroRNAs - metabolism</subject><subject>Oxaliplatin</subject><subject>Transfection</subject><subject>Tumor Development</subject><subject>Uterine Cervical Neoplasms - genetics</subject><subject>Uterine Cervical Neoplasms - metabolism</subject><issn>0965-0407</issn><issn>1555-3906</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU9v1DAQxS1ERZfCV0A5cgmM7Ti2L0ho-4dKFUUVSNxGjuukrpJ4sZOg9tPjZbcrEMKXsTRvfvP0hpCCwjsumXwPuhZQAZXfaaVqyWolldS1fkZWVAhRcg31c7Laysqsk8fkZUr3AKySlX5BjplilaCSrsj54G9KqqgpLsc73_gpFWsXF29NX6zNaF0sTt3i-rAZ3DgVizfFafg5RtfNvZn82BUXN1-kekWOWtMn93pfT8i387Ov60_l1fXF5frjVWlFVU-ldm3LZG2gcVC3jYJs30qZTXHaNBwaLbWwTllmG8MFNKa1SlDOKyetcpafkA877mZuBndrs6doetxEP5j4gMF4_Lsz-jvswoJSVRR4nQFv94AYfswuTTj4ZF3fm9GFOSFVknOdM4UsVTupjSGl6NrDGgq4PQP-7wx59M2fNg-DT7lnweedICeYnRq8D3Mcc3LoLdrQPaElLkyMChkwCirvpSAo3rrWzP2Ek4nYPWLKAR2C-Qe4pYWYCTQb_v2Y2H9AoYlTrhnwC9QusG8</recordid><startdate>20170921</startdate><enddate>20170921</enddate><creator>Luo, Chengyan</creator><creator>Qiu, Jiangnan</creator><general>Cognizant Communication Corporation</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20170921</creationdate><title>miR-181a Inhibits Cervical Cancer Development via Downregulating GRP78</title><author>Luo, Chengyan ; Qiu, Jiangnan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-9eff276a0be06fb80148c7774931bb30b9795ce8c2cba350bafc851334e7c8ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Cell Line, Tumor</topic><topic>Cervical Cancer</topic><topic>Disease Models, Animal</topic><topic>Down-Regulation</topic><topic>Female</topic><topic>Glucose-Regulated Protein 78 (grp78)</topic><topic>Heat-Shock Proteins - genetics</topic><topic>Heat-Shock Proteins - metabolism</topic><topic>HeLa Cells</topic><topic>Heterografts</topic><topic>Humans</topic><topic>Mice</topic><topic>Mice, Nude</topic><topic>Microrna-181a</topic><topic>MicroRNAs - genetics</topic><topic>MicroRNAs - metabolism</topic><topic>Oxaliplatin</topic><topic>Transfection</topic><topic>Tumor Development</topic><topic>Uterine Cervical Neoplasms - genetics</topic><topic>Uterine Cervical Neoplasms - metabolism</topic><toplevel>online_resources</toplevel><creatorcontrib>Luo, Chengyan</creatorcontrib><creatorcontrib>Qiu, Jiangnan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Oncology research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Luo, Chengyan</au><au>Qiu, Jiangnan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>miR-181a Inhibits Cervical Cancer Development via Downregulating GRP78</atitle><jtitle>Oncology research</jtitle><addtitle>Oncol Res</addtitle><date>2017-09-21</date><risdate>2017</risdate><volume>25</volume><issue>8</issue><spage>1341</spage><epage>1348</epage><pages>1341-1348</pages><issn>0965-0407</issn><eissn>1555-3906</eissn><abstract>Cervical cancer is among the most common cancers inflicting women worldwide. Understanding the pathological mechanisms of cervical cancer development is critical for identifying novel targets for cervical cancer treatment. MicroRNAs (miRs) have various roles in regulating cancer development.
In this study, we investigated the potential role of miR-181a and its target in regulating cervical cancer development and chemotherapy resistance. The expression of miR-181a was evaluated and modulated in several human cervical cancer cell lines. The role of miR-181a in regulating cervical
cancer growth and chemotherapy sensitivity was investigated in cell culture models and mouse tumor xenograft models. The target of miR-181a and its function were identified in cervical cancer models. We found a distinct expression profile for miR-181a in cervical cancer cell lines. Low expression
of miR-181a was closely related to cervical cancer growth and oxaliplatin resistance. HSPA5/GRP78 was identified as a target of miR-181a in cervical cancer cells. Upregulation of GRP78 led to a high cell proliferation rate and oxaliplatin resistance in cervical cancer models. In a retrospective
cervical cancer cohort, high GRP78 expression was correlated with poor survival. miR-181a suppressed cervical cancer development via downregulating GRP78. High expression of GRP78 is a tumor-promoting factor in cervical cancer and is thus a potential target for novel treatment.</abstract><cop>Elmsford, NY</cop><pub>Cognizant Communication Corporation</pub><pmid>28245171</pmid><doi>10.3727/096504017X14867268787969</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals Cell Line, Tumor Cervical Cancer Disease Models, Animal Down-Regulation Female Glucose-Regulated Protein 78 (grp78) Heat-Shock Proteins - genetics Heat-Shock Proteins - metabolism HeLa Cells Heterografts Humans Mice Mice, Nude Microrna-181a MicroRNAs - genetics MicroRNAs - metabolism Oxaliplatin Transfection Tumor Development Uterine Cervical Neoplasms - genetics Uterine Cervical Neoplasms - metabolism |
| title | miR-181a Inhibits Cervical Cancer Development via Downregulating GRP78 |
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