Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing

Lung adenocarcinomas (LUAD) that radiologically display as subsolid nodules (SSNs) exhibit more indolent biological behavior than solid LUAD. The transcriptomic features and tumor microenvironment (TME) of SSN remain poorly understood. Here, we performed single-cell RNA sequencing analyses of 16 SSN...

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Veröffentlicht in:	Science advances 2021-01, Vol.7 (5)
Hauptverfasser:	Xing, Xudong, Yang, Fan, Huang, Qi, Guo, Haifa, Li, Jiawei, Qiu, Mantang, Bai, Fan, Wang, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma of Lung - genetics Adenocarcinoma of Lung - pathology Cancer Ecosystem Endothelial Cells - pathology Humans Lung Neoplasms - genetics Lung Neoplasms - pathology SciAdv r-articles Sequence Analysis, RNA Systems Biology Tomography, X-Ray Computed Tumor Microenvironment - genetics
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