Single-cell molecular profiling of all three components of the HPA axis reveals adrenal ABCB1 as a regulator of stress adaptation

Chronic activation and dysregulation of the neuroendocrine stress response have severe physiological and psychological consequences, including the development of metabolic and stress-related psychiatric disorders. We provide the first unbiased, cell type-specific, molecular characterization of all t...

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Veröffentlicht in:Science advances 2021-01, Vol.7 (5)
Hauptverfasser: Lopez, Juan Pablo, Brivio, Elena, Santambrogio, Alice, De Donno, Carlo, Kos, Aron, Peters, Miriam, Rost, Nicolas, Czamara, Darina, Brückl, Tanja M, Roeh, Simone, Pöhlmann, Max L, Engelhardt, Clara, Ressle, Andrea, Stoffel, Rainer, Tontsch, Alina, Villamizar, Javier M, Reincke, Martin, Riester, Anna, Sbiera, Silviu, Fassnacht, Martin, Mayberg, Helen S, Craighead, W Edward, Dunlop, Boadie W, Nemeroff, Charles B, Schmidt, Mathias V, Binder, Elisabeth B, Theis, Fabian J, Beuschlein, Felix, Andoniadou, Cynthia L, Chen, Alon
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