Genome-wide CRISPR-Cas9 screen identified KLF11 as a druggable suppressor for sarcoma cancer stem cells

Cancer stem cells (CSCs) are involved in tumorigenesis, recurrence, and therapy resistance. To identify critical regulators of sarcoma CSCs, we performed a reporter-based genome-wide CRISPR-Cas9 screen and uncovered Kruppel-like factor 11 (KLF11) as top candidate. In vitro and in vivo functional ann...

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Veröffentlicht in:	Science advances 2021-01, Vol.7 (5)
Hauptverfasser:	Wang, Yicun, Wu, Jinhui, Chen, Hui, Yang, Yang, Xiao, Chengwu, Yi, Xiaoming, Shi, Changjie, Zhong, Ke, He, Haowei, Li, Yaoming, Wu, Zhenjie, Zhou, Guangxin, Rao, Qiu, Wang, Xiaoxia, Zhou, Xiaodie, Lomberk, Gwen, Liu, Bing, Zhao, Jianning, Ge, Jingping, Zhou, Wenquan, Chu, Xiaoyuan, Chen, Cheng, Zhou, Xuhui, Wang, Linhui, Guan, Kunliang, Qu, Le
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Regulatory Proteins - metabolism Cancer Cell Biology CRISPR-Cas Systems - genetics Humans Neoplastic Stem Cells - metabolism Repressor Proteins - metabolism Sarcoma - drug therapy Sarcoma - genetics SciAdv r-articles
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