Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz

Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz

Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure func...

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Veröffentlicht in:Optica 2019-03, Vol.6 (3), p.300-303
Hauptverfasser: Azimipour, Mehdi, Migacz, Justin V, Zawadzki, Robert J, Werner, John S, Jonnal, Ravi S
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container_start_page 300
container_title Optica
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creator Azimipour, Mehdi
Migacz, Justin V
Zawadzki, Robert J
Werner, John S
Jonnal, Ravi S
description Objective optical assessment of photoreceptor function may permit earlier diagnosis of retinal disease than current methods such as perimetry, electrophysiology, and clinical imaging. In this work, we describe an adaptive optics (AO) optical coherence tomography (OCT) system designed to measure functional responses of single cones to visible stimuli. The OCT subsystem consisted of a raster-scanning Fourier-domain mode-locked laser that acquires A scans at 1.64 MHz with a center wavelength of 1063 nm and an AO system operating in closed-loop. Analysis of serial volumetric images revealed phase changes of cone photoreceptors consistent with outer segment elongation and proportional to stimulus intensity, as well as other morphological changes in the outer segment and retinal pigment epithelium.
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title Functional retinal imaging using adaptive optics swept-source OCT at 1.6 MHz
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