Impact of surgical margin on survival in extremity soft tissue sarcoma: A systematic review and meta-analysis
The impact of surgical margin status on the survival of patients with extremity soft tissue sarcoma (STS) remains to be clearly defined. The evidence regarding the impact of surgical margins on survival is limited by retrospective single-institution cohort studies. We conducted a systematic review a...
Gespeichert in:
| Veröffentlicht in: | Medicine (Baltimore) 2021-01, Vol.100 (3), p.e24124-e24124 |
|---|---|
| Hauptverfasser: | , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | e24124 |
|---|---|
| container_issue | 3 |
| container_start_page | e24124 |
| container_title | Medicine (Baltimore) |
| container_volume | 100 |
| creator | Jang, Woo Young Kim, Han-Soo Han, Ilkyu |
| description | The impact of surgical margin status on the survival of patients with extremity soft tissue sarcoma (STS) remains to be clearly defined. The evidence regarding the impact of surgical margins on survival is limited by retrospective single-institution cohort studies. We conducted a systematic review and meta-analysis to examine the impact of surgical margin status on patient survival in extremity STS.
A literature search in the PubMed, EMBASE, and Cochrane Controlled Trials Register electronic databases, and a manual search of reference lists of original studies was performed. The following text words and/or Medical Subject Heading terms were searched: (neoplasm) or/and (sarcoma) and/or (connective tissue) and/or (soft tissue) and/or (extremity) and/or (extremity) and/or (surgical margin).
Six selected studies that reported a total of 2917 cases of extremity STS were published between 1994 and 2013. All the eligible studies were observational cohort studies, and the sample size ranged from 95 to 1261 patients. A meta-analysis of 6 studies showed that a positive surgical margin predicted poor 5-year OS in a random-effects model (summary hazard ratio, 1.56; 95% confidence interval, 1.12-2.17). Moderate heterogeneity was observed among the studies (P |
| doi_str_mv | 10.1097/MD.0000000000024124 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7837970</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2487157913</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3551-e079b11f498c32f3aca7362cf4dccf180fa055c10c3bedf97c65b8f0ebb641e3</originalsourceid><addsrcrecordid>eNpdkUtv3CAUhVHVqJmm_QWVKpbdOOFp7C4qRUkfkRJ1kz3CzCVDi80U8Ezm35dk0jzKBjicey7wIfSBkmNKenVydX5MngYTlIlXaEElbxvZt-I1WlRVNqpX4hC9zfkXIZQrJt6gQ86laAmjCzRejGtjC44O5zndeGsCHk1dTDhOd9LGb6pUt3BbEoy-7HCOruDic54BZ5NsHM1nfIrzLhcYTfEWJ9h42GIzLfEIxTRmMmGXfX6HDpwJGd4_zEfo-tvX67MfzeXP7xdnp5eN5VLSBojqB0qd6DvLmePGGsVbZp1YWutoR5whUlpKLB9g6XplWzl0jsAwtIICP0Jf9rHreRhhaWEqyQS9Tr4-baej8frlyeRX-iZutOp4_S5SAz49BKT4Z4Zc9OizhRDMBHHOmolOUal6yquV7602xZwTuMc2lOg7TvrqXP_PqVZ9fH7Dx5p_YKpB7A3bGAqk_DvMW0h6BSaU1X1ebc8aVr2EMkaaCrfi_QsroqC5</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2487157913</pqid></control><display><type>article</type><title>Impact of surgical margin on survival in extremity soft tissue sarcoma: A systematic review and meta-analysis</title><source>Wolters Kluwer Open Health</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>IngentaConnect Free/Open Access Journals</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Jang, Woo Young ; Kim, Han-Soo ; Han, Ilkyu</creator><creatorcontrib>Jang, Woo Young ; Kim, Han-Soo ; Han, Ilkyu</creatorcontrib><description>The impact of surgical margin status on the survival of patients with extremity soft tissue sarcoma (STS) remains to be clearly defined. The evidence regarding the impact of surgical margins on survival is limited by retrospective single-institution cohort studies. We conducted a systematic review and meta-analysis to examine the impact of surgical margin status on patient survival in extremity STS.
A literature search in the PubMed, EMBASE, and Cochrane Controlled Trials Register electronic databases, and a manual search of reference lists of original studies was performed. The following text words and/or Medical Subject Heading terms were searched: (neoplasm) or/and (sarcoma) and/or (connective tissue) and/or (soft tissue) and/or (extremity) and/or (extremity) and/or (surgical margin).
Six selected studies that reported a total of 2917 cases of extremity STS were published between 1994 and 2013. All the eligible studies were observational cohort studies, and the sample size ranged from 95 to 1261 patients. A meta-analysis of 6 studies showed that a positive surgical margin predicted poor 5-year OS in a random-effects model (summary hazard ratio, 1.56; 95% confidence interval, 1.12-2.17). Moderate heterogeneity was observed among the studies (P < .075; heterogeneity, 45.6%).
This meta-analysis supports the hypothesis that adequate surgical margins are associated with improved survival in extremity STS.</description><identifier>ISSN: 0025-7974</identifier><identifier>EISSN: 1536-5964</identifier><identifier>DOI: 10.1097/MD.0000000000024124</identifier><identifier>PMID: 33546021</identifier><language>eng</language><publisher>United States: Lippincott Williams & Wilkins</publisher><subject>Extremities - surgery ; Humans ; Margins of Excision ; Sarcoma - mortality ; Sarcoma - surgery ; Soft Tissue Neoplasms - mortality ; Soft Tissue Neoplasms - surgery ; Systematic Review and Meta-Analysis</subject><ispartof>Medicine (Baltimore), 2021-01, Vol.100 (3), p.e24124-e24124</ispartof><rights>Lippincott Williams & Wilkins</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.</rights><rights>Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3551-e079b11f498c32f3aca7362cf4dccf180fa055c10c3bedf97c65b8f0ebb641e3</cites><orcidid>0000-0001-9841-3775</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837970/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837970/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33546021$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jang, Woo Young</creatorcontrib><creatorcontrib>Kim, Han-Soo</creatorcontrib><creatorcontrib>Han, Ilkyu</creatorcontrib><title>Impact of surgical margin on survival in extremity soft tissue sarcoma: A systematic review and meta-analysis</title><title>Medicine (Baltimore)</title><addtitle>Medicine (Baltimore)</addtitle><description>The impact of surgical margin status on the survival of patients with extremity soft tissue sarcoma (STS) remains to be clearly defined. The evidence regarding the impact of surgical margins on survival is limited by retrospective single-institution cohort studies. We conducted a systematic review and meta-analysis to examine the impact of surgical margin status on patient survival in extremity STS.
A literature search in the PubMed, EMBASE, and Cochrane Controlled Trials Register electronic databases, and a manual search of reference lists of original studies was performed. The following text words and/or Medical Subject Heading terms were searched: (neoplasm) or/and (sarcoma) and/or (connective tissue) and/or (soft tissue) and/or (extremity) and/or (extremity) and/or (surgical margin).
Six selected studies that reported a total of 2917 cases of extremity STS were published between 1994 and 2013. All the eligible studies were observational cohort studies, and the sample size ranged from 95 to 1261 patients. A meta-analysis of 6 studies showed that a positive surgical margin predicted poor 5-year OS in a random-effects model (summary hazard ratio, 1.56; 95% confidence interval, 1.12-2.17). Moderate heterogeneity was observed among the studies (P < .075; heterogeneity, 45.6%).
This meta-analysis supports the hypothesis that adequate surgical margins are associated with improved survival in extremity STS.</description><subject>Extremities - surgery</subject><subject>Humans</subject><subject>Margins of Excision</subject><subject>Sarcoma - mortality</subject><subject>Sarcoma - surgery</subject><subject>Soft Tissue Neoplasms - mortality</subject><subject>Soft Tissue Neoplasms - surgery</subject><subject>Systematic Review and Meta-Analysis</subject><issn>0025-7974</issn><issn>1536-5964</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtv3CAUhVHVqJmm_QWVKpbdOOFp7C4qRUkfkRJ1kz3CzCVDi80U8Ezm35dk0jzKBjicey7wIfSBkmNKenVydX5MngYTlIlXaEElbxvZt-I1WlRVNqpX4hC9zfkXIZQrJt6gQ86laAmjCzRejGtjC44O5zndeGsCHk1dTDhOd9LGb6pUt3BbEoy-7HCOruDic54BZ5NsHM1nfIrzLhcYTfEWJ9h42GIzLfEIxTRmMmGXfX6HDpwJGd4_zEfo-tvX67MfzeXP7xdnp5eN5VLSBojqB0qd6DvLmePGGsVbZp1YWutoR5whUlpKLB9g6XplWzl0jsAwtIICP0Jf9rHreRhhaWEqyQS9Tr4-baej8frlyeRX-iZutOp4_S5SAz49BKT4Z4Zc9OizhRDMBHHOmolOUal6yquV7602xZwTuMc2lOg7TvrqXP_PqVZ9fH7Dx5p_YKpB7A3bGAqk_DvMW0h6BSaU1X1ebc8aVr2EMkaaCrfi_QsroqC5</recordid><startdate>20210122</startdate><enddate>20210122</enddate><creator>Jang, Woo Young</creator><creator>Kim, Han-Soo</creator><creator>Han, Ilkyu</creator><general>Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-9841-3775</orcidid></search><sort><creationdate>20210122</creationdate><title>Impact of surgical margin on survival in extremity soft tissue sarcoma: A systematic review and meta-analysis</title><author>Jang, Woo Young ; Kim, Han-Soo ; Han, Ilkyu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3551-e079b11f498c32f3aca7362cf4dccf180fa055c10c3bedf97c65b8f0ebb641e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Extremities - surgery</topic><topic>Humans</topic><topic>Margins of Excision</topic><topic>Sarcoma - mortality</topic><topic>Sarcoma - surgery</topic><topic>Soft Tissue Neoplasms - mortality</topic><topic>Soft Tissue Neoplasms - surgery</topic><topic>Systematic Review and Meta-Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jang, Woo Young</creatorcontrib><creatorcontrib>Kim, Han-Soo</creatorcontrib><creatorcontrib>Han, Ilkyu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Medicine (Baltimore)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jang, Woo Young</au><au>Kim, Han-Soo</au><au>Han, Ilkyu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impact of surgical margin on survival in extremity soft tissue sarcoma: A systematic review and meta-analysis</atitle><jtitle>Medicine (Baltimore)</jtitle><addtitle>Medicine (Baltimore)</addtitle><date>2021-01-22</date><risdate>2021</risdate><volume>100</volume><issue>3</issue><spage>e24124</spage><epage>e24124</epage><pages>e24124-e24124</pages><issn>0025-7974</issn><eissn>1536-5964</eissn><abstract>The impact of surgical margin status on the survival of patients with extremity soft tissue sarcoma (STS) remains to be clearly defined. The evidence regarding the impact of surgical margins on survival is limited by retrospective single-institution cohort studies. We conducted a systematic review and meta-analysis to examine the impact of surgical margin status on patient survival in extremity STS.
A literature search in the PubMed, EMBASE, and Cochrane Controlled Trials Register electronic databases, and a manual search of reference lists of original studies was performed. The following text words and/or Medical Subject Heading terms were searched: (neoplasm) or/and (sarcoma) and/or (connective tissue) and/or (soft tissue) and/or (extremity) and/or (extremity) and/or (surgical margin).
Six selected studies that reported a total of 2917 cases of extremity STS were published between 1994 and 2013. All the eligible studies were observational cohort studies, and the sample size ranged from 95 to 1261 patients. A meta-analysis of 6 studies showed that a positive surgical margin predicted poor 5-year OS in a random-effects model (summary hazard ratio, 1.56; 95% confidence interval, 1.12-2.17). Moderate heterogeneity was observed among the studies (P < .075; heterogeneity, 45.6%).
This meta-analysis supports the hypothesis that adequate surgical margins are associated with improved survival in extremity STS.</abstract><cop>United States</cop><pub>Lippincott Williams & Wilkins</pub><pmid>33546021</pmid><doi>10.1097/MD.0000000000024124</doi><orcidid>https://orcid.org/0000-0001-9841-3775</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0025-7974 |
| ispartof | Medicine (Baltimore), 2021-01, Vol.100 (3), p.e24124-e24124 |
| issn | 0025-7974 1536-5964 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7837970 |
| source | Wolters Kluwer Open Health; MEDLINE; DOAJ Directory of Open Access Journals; IngentaConnect Free/Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Extremities - surgery Humans Margins of Excision Sarcoma - mortality Sarcoma - surgery Soft Tissue Neoplasms - mortality Soft Tissue Neoplasms - surgery Systematic Review and Meta-Analysis |
| title | Impact of surgical margin on survival in extremity soft tissue sarcoma: A systematic review and meta-analysis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-03T02%3A46%3A25IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Impact%20of%20surgical%20margin%20on%20survival%20in%20extremity%20soft%20tissue%20sarcoma:%20A%20systematic%20review%20and%20meta-analysis&rft.jtitle=Medicine%20(Baltimore)&rft.au=Jang,%20Woo%20Young&rft.date=2021-01-22&rft.volume=100&rft.issue=3&rft.spage=e24124&rft.epage=e24124&rft.pages=e24124-e24124&rft.issn=0025-7974&rft.eissn=1536-5964&rft_id=info:doi/10.1097/MD.0000000000024124&rft_dat=%3Cproquest_pubme%3E2487157913%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2487157913&rft_id=info:pmid/33546021&rfr_iscdi=true |