Effect of Micronization on Panax notoginseng: In Vitro Dissolution and In Vivo Bioavailability Evaluations
Panax notoginseng (PN) has become the most widely used dietary supplement and herbal in Asian countries. The effect of micronization on PN is not entirely clear. The aim of this study was to investigate the effects of particle size of Panax notoginseng powder (PNP) and the potential to improve the b...
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| Veröffentlicht in: | Evidence-based complementary and alternative medicine 2021, Vol.2021 (NA), p.8831583-11 |
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| creator | Liang, Xiao Xu, Guobing Li, Zhenbao Xuan, Zihua Zhao, Hongsu Peng, Daiyin Gui, Shuangying |
| description | Panax notoginseng (PN) has become the most widely used dietary supplement and herbal in Asian countries. The effect of micronization on PN is not entirely clear. The aim of this study was to investigate the effects of particle size of Panax notoginseng powder (PNP) and the potential to improve the bioavailability. The results showed that particle size reduction significantly changed the Panax notoginseng saponins (PNS) in vitro dissolution and in vivo pharmacokinetics. The size of the Panax notoginseng powder (PNP) ranges from 60 to 214 μm. The surface morphology and thermal properties of PNP were extensively characterized, and these changes in physicochemical properties of PNP provide a better understanding of the in vitro and in vivo release behaviors of PNS. The in vitro studies demonstrated that the dissolution of PNS and particle size were nonlinear (dose- and size-dependent). The pharmacokinetics parameters of PNP in rats were determined by UHPLC-MS/MS. Powder 4 (90.38 ± 8.28 μm) showed significantly higher AUC0-T values in plasma P |
| doi_str_mv | 10.1155/2021/8831583 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7837785</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2521438101</sourcerecordid><originalsourceid>FETCH-LOGICAL-c481t-2694f59f5324fee399f0f9580881c1c72cea80044d17272296881fc2b9eb15c23</originalsourceid><addsrcrecordid>eNp9kUFrVDEURoMotlZ3riXgRtCxuTfJJOlC0DpqoaILFXchk0mmGd4k9eW90frrTTvjoC6EQALf4ZB7P0IeAnsOIOUxMoRjrTlIzW-RQ1ACJgK1vr1_q68H5F6tK8bQKKXukgPOJQeDcEhWsxiDH2iJ9H3yfcnppxtSybSdjy67HzSXoSxTriEvT-hZpl_S0Bf6OtVauvEGdXmxDTaFvkrFbVzq3Dx1abiis43rxhtjvU_uRNfV8GB3H5HPb2afTt9Nzj-8PTt9eT7xQsMwwakRUZooOYoYAjcmsmikZlqDB6_QB6cZE2IBChWimbYgepybMAfpkR-RF1vv5Thfh4UPeehdZy_7tHb9lS0u2b-TnC7ssmys0lwpLZvgyU7Ql29jqINdp-pD17kcylgtSgTBNTBo6ON_0FUZ-9zGsyi0ACFxKhr1bEu1Bdfah7j_DDB7XaK9LtHuSmz4oz8H2MO_W2vA0y1wkfLCfU__1_0Cx3SkfQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2484145264</pqid></control><display><type>article</type><title>Effect of Micronization on Panax notoginseng: In Vitro Dissolution and In Vivo Bioavailability Evaluations</title><source>Wiley-Blackwell Open Access Collection</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><source>EZB Electronic Journals Library</source><source>PubMed Central Open Access</source><creator>Liang, Xiao ; Xu, Guobing ; Li, Zhenbao ; Xuan, Zihua ; Zhao, Hongsu ; Peng, Daiyin ; Gui, Shuangying</creator><contributor>Ferraro, Maria</contributor><creatorcontrib>Liang, Xiao ; Xu, Guobing ; Li, Zhenbao ; Xuan, Zihua ; Zhao, Hongsu ; Peng, Daiyin ; Gui, Shuangying ; Ferraro, Maria</creatorcontrib><description>Panax notoginseng (PN) has become the most widely used dietary supplement and herbal in Asian countries. The effect of micronization on PN is not entirely clear. The aim of this study was to investigate the effects of particle size of Panax notoginseng powder (PNP) and the potential to improve the bioavailability. The results showed that particle size reduction significantly changed the Panax notoginseng saponins (PNS) in vitro dissolution and in vivo pharmacokinetics. The size of the Panax notoginseng powder (PNP) ranges from 60 to 214 μm. The surface morphology and thermal properties of PNP were extensively characterized, and these changes in physicochemical properties of PNP provide a better understanding of the in vitro and in vivo release behaviors of PNS. The in vitro studies demonstrated that the dissolution of PNS and particle size were nonlinear (dose- and size-dependent). The pharmacokinetics parameters of PNP in rats were determined by UHPLC-MS/MS. Powder 4 (90.38 ± 8.28 μm) showed significantly higher AUC0-T values in plasma P<0.05. In addition, we also investigated the influence of the hydrothermal treatment of PNP. The results showed that the PNS in vitro release and in vivo bioavailability of PNP pretreatment at 40°C were the highest. This suggests that PNP with a particle size of around 90 μm and heat pretreatment at 40°C would be beneficial. These results provided an experimental basis, and it was beneficial to choose an appropriate particle size and hydrothermal temperature when PNP was used in clinical treatment.</description><identifier>ISSN: 1741-427X</identifier><identifier>EISSN: 1741-4288</identifier><identifier>DOI: 10.1155/2021/8831583</identifier><identifier>PMID: 33531921</identifier><language>eng</language><publisher>United States: Hindawi</publisher><subject>Bioavailability ; Chinese medicine ; Dietary supplements ; Dissolution ; Laboratory animals ; Morphology ; Panax notoginseng ; Particle size ; Pharmacokinetics ; Physicochemical properties ; Powder ; Saponins ; Scanning electron microscopy</subject><ispartof>Evidence-based complementary and alternative medicine, 2021, Vol.2021 (NA), p.8831583-11</ispartof><rights>Copyright © 2021 Xiao Liang et al.</rights><rights>Copyright © 2021 Xiao Liang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2021 Xiao Liang et al. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c481t-2694f59f5324fee399f0f9580881c1c72cea80044d17272296881fc2b9eb15c23</citedby><cites>FETCH-LOGICAL-c481t-2694f59f5324fee399f0f9580881c1c72cea80044d17272296881fc2b9eb15c23</cites><orcidid>0000-0002-3855-6632 ; 0000-0003-0998-0300</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837785/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7837785/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,4010,27900,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33531921$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Ferraro, Maria</contributor><creatorcontrib>Liang, Xiao</creatorcontrib><creatorcontrib>Xu, Guobing</creatorcontrib><creatorcontrib>Li, Zhenbao</creatorcontrib><creatorcontrib>Xuan, Zihua</creatorcontrib><creatorcontrib>Zhao, Hongsu</creatorcontrib><creatorcontrib>Peng, Daiyin</creatorcontrib><creatorcontrib>Gui, Shuangying</creatorcontrib><title>Effect of Micronization on Panax notoginseng: In Vitro Dissolution and In Vivo Bioavailability Evaluations</title><title>Evidence-based complementary and alternative medicine</title><addtitle>Evid Based Complement Alternat Med</addtitle><description>Panax notoginseng (PN) has become the most widely used dietary supplement and herbal in Asian countries. The effect of micronization on PN is not entirely clear. The aim of this study was to investigate the effects of particle size of Panax notoginseng powder (PNP) and the potential to improve the bioavailability. The results showed that particle size reduction significantly changed the Panax notoginseng saponins (PNS) in vitro dissolution and in vivo pharmacokinetics. The size of the Panax notoginseng powder (PNP) ranges from 60 to 214 μm. The surface morphology and thermal properties of PNP were extensively characterized, and these changes in physicochemical properties of PNP provide a better understanding of the in vitro and in vivo release behaviors of PNS. The in vitro studies demonstrated that the dissolution of PNS and particle size were nonlinear (dose- and size-dependent). The pharmacokinetics parameters of PNP in rats were determined by UHPLC-MS/MS. Powder 4 (90.38 ± 8.28 μm) showed significantly higher AUC0-T values in plasma P<0.05. In addition, we also investigated the influence of the hydrothermal treatment of PNP. The results showed that the PNS in vitro release and in vivo bioavailability of PNP pretreatment at 40°C were the highest. This suggests that PNP with a particle size of around 90 μm and heat pretreatment at 40°C would be beneficial. These results provided an experimental basis, and it was beneficial to choose an appropriate particle size and hydrothermal temperature when PNP was used in clinical treatment.</description><subject>Bioavailability</subject><subject>Chinese medicine</subject><subject>Dietary supplements</subject><subject>Dissolution</subject><subject>Laboratory animals</subject><subject>Morphology</subject><subject>Panax notoginseng</subject><subject>Particle size</subject><subject>Pharmacokinetics</subject><subject>Physicochemical properties</subject><subject>Powder</subject><subject>Saponins</subject><subject>Scanning electron microscopy</subject><issn>1741-427X</issn><issn>1741-4288</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kUFrVDEURoMotlZ3riXgRtCxuTfJJOlC0DpqoaILFXchk0mmGd4k9eW90frrTTvjoC6EQALf4ZB7P0IeAnsOIOUxMoRjrTlIzW-RQ1ACJgK1vr1_q68H5F6tK8bQKKXukgPOJQeDcEhWsxiDH2iJ9H3yfcnppxtSybSdjy67HzSXoSxTriEvT-hZpl_S0Bf6OtVauvEGdXmxDTaFvkrFbVzq3Dx1abiis43rxhtjvU_uRNfV8GB3H5HPb2afTt9Nzj-8PTt9eT7xQsMwwakRUZooOYoYAjcmsmikZlqDB6_QB6cZE2IBChWimbYgepybMAfpkR-RF1vv5Thfh4UPeehdZy_7tHb9lS0u2b-TnC7ssmys0lwpLZvgyU7Ql29jqINdp-pD17kcylgtSgTBNTBo6ON_0FUZ-9zGsyi0ACFxKhr1bEu1Bdfah7j_DDB7XaK9LtHuSmz4oz8H2MO_W2vA0y1wkfLCfU__1_0Cx3SkfQ</recordid><startdate>2021</startdate><enddate>2021</enddate><creator>Liang, Xiao</creator><creator>Xu, Guobing</creator><creator>Li, Zhenbao</creator><creator>Xuan, Zihua</creator><creator>Zhao, Hongsu</creator><creator>Peng, Daiyin</creator><creator>Gui, Shuangying</creator><general>Hindawi</general><general>Hindawi Limited</general><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88G</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M2M</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-3855-6632</orcidid><orcidid>https://orcid.org/0000-0003-0998-0300</orcidid></search><sort><creationdate>2021</creationdate><title>Effect of Micronization on Panax notoginseng: In Vitro Dissolution and In Vivo Bioavailability Evaluations</title><author>Liang, Xiao ; Xu, Guobing ; Li, Zhenbao ; Xuan, Zihua ; Zhao, Hongsu ; Peng, Daiyin ; Gui, Shuangying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c481t-2694f59f5324fee399f0f9580881c1c72cea80044d17272296881fc2b9eb15c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Bioavailability</topic><topic>Chinese medicine</topic><topic>Dietary supplements</topic><topic>Dissolution</topic><topic>Laboratory animals</topic><topic>Morphology</topic><topic>Panax notoginseng</topic><topic>Particle size</topic><topic>Pharmacokinetics</topic><topic>Physicochemical properties</topic><topic>Powder</topic><topic>Saponins</topic><topic>Scanning electron microscopy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liang, Xiao</creatorcontrib><creatorcontrib>Xu, Guobing</creatorcontrib><creatorcontrib>Li, Zhenbao</creatorcontrib><creatorcontrib>Xuan, Zihua</creatorcontrib><creatorcontrib>Zhao, Hongsu</creatorcontrib><creatorcontrib>Peng, Daiyin</creatorcontrib><creatorcontrib>Gui, Shuangying</creatorcontrib><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Psychology Database (Alumni)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Psychology Database (ProQuest)</collection><collection>ProQuest Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Evidence-based complementary and alternative medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liang, Xiao</au><au>Xu, Guobing</au><au>Li, Zhenbao</au><au>Xuan, Zihua</au><au>Zhao, Hongsu</au><au>Peng, Daiyin</au><au>Gui, Shuangying</au><au>Ferraro, Maria</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of Micronization on Panax notoginseng: In Vitro Dissolution and In Vivo Bioavailability Evaluations</atitle><jtitle>Evidence-based complementary and alternative medicine</jtitle><addtitle>Evid Based Complement Alternat Med</addtitle><date>2021</date><risdate>2021</risdate><volume>2021</volume><issue>NA</issue><spage>8831583</spage><epage>11</epage><pages>8831583-11</pages><issn>1741-427X</issn><eissn>1741-4288</eissn><abstract>Panax notoginseng (PN) has become the most widely used dietary supplement and herbal in Asian countries. The effect of micronization on PN is not entirely clear. The aim of this study was to investigate the effects of particle size of Panax notoginseng powder (PNP) and the potential to improve the bioavailability. The results showed that particle size reduction significantly changed the Panax notoginseng saponins (PNS) in vitro dissolution and in vivo pharmacokinetics. The size of the Panax notoginseng powder (PNP) ranges from 60 to 214 μm. The surface morphology and thermal properties of PNP were extensively characterized, and these changes in physicochemical properties of PNP provide a better understanding of the in vitro and in vivo release behaviors of PNS. The in vitro studies demonstrated that the dissolution of PNS and particle size were nonlinear (dose- and size-dependent). The pharmacokinetics parameters of PNP in rats were determined by UHPLC-MS/MS. Powder 4 (90.38 ± 8.28 μm) showed significantly higher AUC0-T values in plasma P<0.05. In addition, we also investigated the influence of the hydrothermal treatment of PNP. The results showed that the PNS in vitro release and in vivo bioavailability of PNP pretreatment at 40°C were the highest. This suggests that PNP with a particle size of around 90 μm and heat pretreatment at 40°C would be beneficial. These results provided an experimental basis, and it was beneficial to choose an appropriate particle size and hydrothermal temperature when PNP was used in clinical treatment.</abstract><cop>United States</cop><pub>Hindawi</pub><pmid>33531921</pmid><doi>10.1155/2021/8831583</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0002-3855-6632</orcidid><orcidid>https://orcid.org/0000-0003-0998-0300</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Bioavailability Chinese medicine Dietary supplements Dissolution Laboratory animals Morphology Panax notoginseng Particle size Pharmacokinetics Physicochemical properties Powder Saponins Scanning electron microscopy |
| title | Effect of Micronization on Panax notoginseng: In Vitro Dissolution and In Vivo Bioavailability Evaluations |
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