The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection
The role of angiotensin converting enzyme 2 has expanded from regulating the renin angiotensin system to regulating intestinal amino acid homeostasis and the gut microbiome. Recently, angiotensin converting enzyme 2 was identified as a primary receptor for severe acute respiratory syndrome coronavir...
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| Veröffentlicht in: | Gastroenterology (New York, N.Y. 1943) N.Y. 1943), 2021-01, Vol.160 (1), p.39-46 |
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| container_end_page | 46 |
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| container_issue | 1 |
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| container_title | Gastroenterology (New York, N.Y. 1943) |
| container_volume | 160 |
| creator | Penninger, Josef M. Grant, Maria B. Sung, Joseph J.Y. |
| description | The role of angiotensin converting enzyme 2 has expanded from regulating the renin angiotensin system to regulating intestinal amino acid homeostasis and the gut microbiome. Recently, angiotensin converting enzyme 2 was identified as a primary receptor for severe acute respiratory syndrome coronaviruses 1 and 2 being expressed in multiple tissues including the luminal surface of the gut. In this brief perspective, we examine the role of angiotensin converting enzyme 2 as the receptor for severe acute respiratory syndrome coronavirus 2 and the impact of coronavirus disease 19 infection on the gut microbiome and on the gut epithelium. |
| doi_str_mv | 10.1053/j.gastro.2020.07.067 |
| format | Article |
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Recently, angiotensin converting enzyme 2 was identified as a primary receptor for severe acute respiratory syndrome coronaviruses 1 and 2 being expressed in multiple tissues including the luminal surface of the gut. In this brief perspective, we examine the role of angiotensin converting enzyme 2 as the receptor for severe acute respiratory syndrome coronavirus 2 and the impact of coronavirus disease 19 infection on the gut microbiome and on the gut epithelium.</description><identifier>ISSN: 0016-5085</identifier><identifier>EISSN: 1528-0012</identifier><identifier>DOI: 10.1053/j.gastro.2020.07.067</identifier><identifier>PMID: 33130103</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>ACE2 ; Angiotensin-Converting Enzyme 2 - metabolism ; Angiotensin-Converting Enzyme 2 - therapeutic use ; Animals ; Anti-Inflammatory Agents - therapeutic use ; Antiviral Agents - therapeutic use ; COVID-19 - drug therapy ; COVID-19 - enzymology ; COVID-19 - microbiology ; COVID-19 - virology ; Feces - microbiology ; Feces - virology ; Gastroenteritis - drug therapy ; Gastroenteritis - enzymology ; Gastroenteritis - microbiology ; Gastroenteritis - virology ; Gastrointestinal Microbiome - drug effects ; Gut Microbiota ; Host-Pathogen Interactions ; Humans ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - enzymology ; Intestinal Mucosa - microbiology ; Intestinal Mucosa - virology ; Receptors, Virus - metabolism ; Renin-Angiotensin System ; Reviews and s ; SAR-CoV-2 ; SARS-CoV-2 - drug effects ; SARS-CoV-2 - pathogenicity ; Virus Internalization</subject><ispartof>Gastroenterology (New York, N.Y. 1943), 2021-01, Vol.160 (1), p.39-46</ispartof><rights>2021 AGA Institute</rights><rights>Copyright © 2021 AGA Institute. 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| language | eng |
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| source | MEDLINE; Access via ScienceDirect (Elsevier); Alma/SFX Local Collection |
| subjects | ACE2 Angiotensin-Converting Enzyme 2 - metabolism Angiotensin-Converting Enzyme 2 - therapeutic use Animals Anti-Inflammatory Agents - therapeutic use Antiviral Agents - therapeutic use COVID-19 - drug therapy COVID-19 - enzymology COVID-19 - microbiology COVID-19 - virology Feces - microbiology Feces - virology Gastroenteritis - drug therapy Gastroenteritis - enzymology Gastroenteritis - microbiology Gastroenteritis - virology Gastrointestinal Microbiome - drug effects Gut Microbiota Host-Pathogen Interactions Humans Intestinal Mucosa - drug effects Intestinal Mucosa - enzymology Intestinal Mucosa - microbiology Intestinal Mucosa - virology Receptors, Virus - metabolism Renin-Angiotensin System Reviews and s SAR-CoV-2 SARS-CoV-2 - drug effects SARS-CoV-2 - pathogenicity Virus Internalization |
| title | The Role of Angiotensin Converting Enzyme 2 in Modulating Gut Microbiota, Intestinal Inflammation, and Coronavirus Infection |
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