Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells
Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and improve functional recovery in experimental model and clinical trials. However, there are still many limitations and unr...
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| Veröffentlicht in: | International journal of molecular sciences 2021-01, Vol.22 (2), p.970 |
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| container_title | International journal of molecular sciences |
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| creator | Liu, Quan-Wen Huang, Qi-Ming Wu, Han-You Zuo, Guo-Si-Lang Gu, Hao-Cheng Deng, Ke-Yu Xin, Hong-Bo |
| description | Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and improve functional recovery in experimental model and clinical trials. However, there are still many limitations and unresolved problems regarding stem cell therapy in terms of ethical barriers, immune rejection, tumorigenicity, and cell sources. By reviewing recent literatures and our related works, human amnion-derived stem cells (hADSCs) including human amniotic mesenchymal stem cells (hAMSCs) and human amniotic epithelial stem cells (hAESCs) have shown considerable advantages over other stem cells. In this review, we first described the biological characteristics and advantages of hADSCs, especially for their high pluripotency and immunomodulatory effects. Then, we summarized the therapeutic applications and recent progresses of hADSCs in treating various diseases for preclinical research and clinical trials. In addition, the possible mechanisms and the challenges of hADSCs applications have been also discussed. Finally, we highlighted the properties of hADSCs as a promising source of stem cells for cell therapy and regenerative medicine and pointed out the perspectives for the directions of hADSCs applications clinically. |
| doi_str_mv | 10.3390/ijms22020970 |
| format | Article |
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However, there are still many limitations and unresolved problems regarding stem cell therapy in terms of ethical barriers, immune rejection, tumorigenicity, and cell sources. By reviewing recent literatures and our related works, human amnion-derived stem cells (hADSCs) including human amniotic mesenchymal stem cells (hAMSCs) and human amniotic epithelial stem cells (hAESCs) have shown considerable advantages over other stem cells. In this review, we first described the biological characteristics and advantages of hADSCs, especially for their high pluripotency and immunomodulatory effects. Then, we summarized the therapeutic applications and recent progresses of hADSCs in treating various diseases for preclinical research and clinical trials. In addition, the possible mechanisms and the challenges of hADSCs applications have been also discussed. Finally, we highlighted the properties of hADSCs as a promising source of stem cells for cell therapy and regenerative medicine and pointed out the perspectives for the directions of hADSCs applications clinically.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22020970</identifier><identifier>PMID: 33478081</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amnion ; Amniotic fluid ; Angiogenesis ; Antigens ; Cell therapy ; Clinical trials ; Embryo cells ; Fetuses ; Fibroblasts ; Growth factors ; Immunomodulation ; Mesenchyme ; Morphology ; Pluripotency ; Recovery of function ; Regenerative medicine ; Review ; Stem cells ; Therapeutic applications ; Tissue engineering ; Tumorigenicity</subject><ispartof>International journal of molecular sciences, 2021-01, Vol.22 (2), p.970</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c478t-5dbbd241e631cf6aaeb1a7715b02c1a3382a180fd8bd26952deff6cec80490e33</citedby><cites>FETCH-LOGICAL-c478t-5dbbd241e631cf6aaeb1a7715b02c1a3382a180fd8bd26952deff6cec80490e33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835733/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835733/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53769,53771</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33478081$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Liu, Quan-Wen</creatorcontrib><creatorcontrib>Huang, Qi-Ming</creatorcontrib><creatorcontrib>Wu, Han-You</creatorcontrib><creatorcontrib>Zuo, Guo-Si-Lang</creatorcontrib><creatorcontrib>Gu, Hao-Cheng</creatorcontrib><creatorcontrib>Deng, Ke-Yu</creatorcontrib><creatorcontrib>Xin, Hong-Bo</creatorcontrib><title>Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and improve functional recovery in experimental model and clinical trials. 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Finally, we highlighted the properties of hADSCs as a promising source of stem cells for cell therapy and regenerative medicine and pointed out the perspectives for the directions of hADSCs applications clinically.</description><subject>Amnion</subject><subject>Amniotic fluid</subject><subject>Angiogenesis</subject><subject>Antigens</subject><subject>Cell therapy</subject><subject>Clinical trials</subject><subject>Embryo cells</subject><subject>Fetuses</subject><subject>Fibroblasts</subject><subject>Growth factors</subject><subject>Immunomodulation</subject><subject>Mesenchyme</subject><subject>Morphology</subject><subject>Pluripotency</subject><subject>Recovery of function</subject><subject>Regenerative medicine</subject><subject>Review</subject><subject>Stem cells</subject><subject>Therapeutic applications</subject><subject>Tissue engineering</subject><subject>Tumorigenicity</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkctLAzEQxoMotlZvniXgxYOreezzIpT1UaGgYD2HbHbWpuxuarJb8L83tbVUTxkyv_lmPj6Ezim54Twjt3rROMYII1lCDtCQhowFhMTJ4V49QCfOLQhhnEXZMRpwHiYpSekQTfO5tFJ1YLXrtHJYtiWezcHKJfT-A7-aDtpOyxqbCk_6RrZ43LTatMG9n1lBid86aHAOde1O0VElawdn23eE3h8fZvkkmL48PefjaaD82i6IyqIoWUgh5lRVsZRQUJkkNCoIU1RynjJJU1KVqcfiLGIlVFWsQKUkzAhwPkJ3G91lXzRQKn-glbVYWt1I-yWM1OJvp9Vz8WFWIkl5lPC1wNVWwJrPHlwnGu2UtyBbML0TLPSrGAk59ejlP3Rhett6ez8U5VEUrgWvN5SyxjkL1e4YSsQ6JrEfk8cv9g3s4N9c-DcXjY6-</recordid><startdate>20210119</startdate><enddate>20210119</enddate><creator>Liu, Quan-Wen</creator><creator>Huang, Qi-Ming</creator><creator>Wu, Han-You</creator><creator>Zuo, Guo-Si-Lang</creator><creator>Gu, Hao-Cheng</creator><creator>Deng, Ke-Yu</creator><creator>Xin, Hong-Bo</creator><general>MDPI AG</general><general>MDPI</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210119</creationdate><title>Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells</title><author>Liu, Quan-Wen ; Huang, Qi-Ming ; Wu, Han-You ; Zuo, Guo-Si-Lang ; Gu, Hao-Cheng ; Deng, Ke-Yu ; Xin, Hong-Bo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c478t-5dbbd241e631cf6aaeb1a7715b02c1a3382a180fd8bd26952deff6cec80490e33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Amnion</topic><topic>Amniotic fluid</topic><topic>Angiogenesis</topic><topic>Antigens</topic><topic>Cell therapy</topic><topic>Clinical trials</topic><topic>Embryo cells</topic><topic>Fetuses</topic><topic>Fibroblasts</topic><topic>Growth factors</topic><topic>Immunomodulation</topic><topic>Mesenchyme</topic><topic>Morphology</topic><topic>Pluripotency</topic><topic>Recovery of function</topic><topic>Regenerative medicine</topic><topic>Review</topic><topic>Stem cells</topic><topic>Therapeutic applications</topic><topic>Tissue engineering</topic><topic>Tumorigenicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Liu, Quan-Wen</creatorcontrib><creatorcontrib>Huang, Qi-Ming</creatorcontrib><creatorcontrib>Wu, Han-You</creatorcontrib><creatorcontrib>Zuo, Guo-Si-Lang</creatorcontrib><creatorcontrib>Gu, Hao-Cheng</creatorcontrib><creatorcontrib>Deng, Ke-Yu</creatorcontrib><creatorcontrib>Xin, Hong-Bo</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest research library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Liu, Quan-Wen</au><au>Huang, Qi-Ming</au><au>Wu, Han-You</au><au>Zuo, Guo-Si-Lang</au><au>Gu, Hao-Cheng</au><au>Deng, Ke-Yu</au><au>Xin, Hong-Bo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2021-01-19</date><risdate>2021</risdate><volume>22</volume><issue>2</issue><spage>970</spage><pages>970-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Stem cells including embryonic stem cells (ESCs), induced pluripotent stem cells (iPSCs) and adult stem cells (ASCs) are able to repair/replace damaged or degenerative tissues and improve functional recovery in experimental model and clinical trials. However, there are still many limitations and unresolved problems regarding stem cell therapy in terms of ethical barriers, immune rejection, tumorigenicity, and cell sources. By reviewing recent literatures and our related works, human amnion-derived stem cells (hADSCs) including human amniotic mesenchymal stem cells (hAMSCs) and human amniotic epithelial stem cells (hAESCs) have shown considerable advantages over other stem cells. In this review, we first described the biological characteristics and advantages of hADSCs, especially for their high pluripotency and immunomodulatory effects. Then, we summarized the therapeutic applications and recent progresses of hADSCs in treating various diseases for preclinical research and clinical trials. In addition, the possible mechanisms and the challenges of hADSCs applications have been also discussed. Finally, we highlighted the properties of hADSCs as a promising source of stem cells for cell therapy and regenerative medicine and pointed out the perspectives for the directions of hADSCs applications clinically.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33478081</pmid><doi>10.3390/ijms22020970</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2021-01, Vol.22 (2), p.970 |
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| source | MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central; EZB Electronic Journals Library |
| subjects | Amnion Amniotic fluid Angiogenesis Antigens Cell therapy Clinical trials Embryo cells Fetuses Fibroblasts Growth factors Immunomodulation Mesenchyme Morphology Pluripotency Recovery of function Regenerative medicine Review Stem cells Therapeutic applications Tissue engineering Tumorigenicity |
| title | Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells |
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