Decorin inhibits the insulin-like growth factor I signaling in bone marrow mesenchymal stem cells of aged humans

Aging impairs the IGF-I signaling of bone marrow mesenchymal stem cells (bmMSCs), but the mechanism is unclear. Here, we found that the ability to auto-phosphorylate IGF-I receptor (IGF-IR) in response to IGF-I was decreased in the bmMSCs of aged donors. Conversely, data showed that decorin (DCN) ex...

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Veröffentlicht in:	Aging (Albany, NY.) NY.), 2021-01, Vol.13 (1), p.578-597
Hauptverfasser:	Wong, Tze-Hong, Chen, Ting-Yu, Tseng, Kuo-Yun, Chen, Zih-Ying, Chen, Chung-Hsing, Lin, Feng-Huei, Wu, Hung-Ming, Lin, Shankung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aging - genetics Amino Acids, Dicarboxylic - pharmacology Bone Marrow Cells - drug effects Bone Marrow Cells - metabolism Decitabine - pharmacology Decorin - drug effects Decorin - genetics Decorin - metabolism DNA Demethylation - drug effects DNA Methylation - drug effects Enzyme Inhibitors - pharmacology Gene Expression Regulation, Developmental - drug effects Gene Expression Regulation, Developmental - genetics Gene Knockdown Techniques Humans Insulin-Like Growth Factor I - metabolism Mesenchymal Stem Cells - drug effects Mesenchymal Stem Cells - metabolism Middle Aged Phosphorylation Receptor, IGF Type 1 - metabolism Research Paper RNA, Messenger - metabolism Signal Transduction
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