Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study
The COVID-19 pandemic causes severe morbidity and mortality. This multi-country study aimed to explore risk factors that drive mortality in COVID-19 patients who received neither dexamethasone nor remdesivir. We analyzed a cohort of 568 survivors and 507 non-survivors from China, European regions, a...
Gespeichert in:
| Veröffentlicht in: | Aging (Albany, NY.) NY.), 2021-01, Vol.13 (1), p.27-60 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 60 |
|---|---|
| container_issue | 1 |
| container_start_page | 27 |
| container_title | Aging (Albany, NY.) |
| container_volume | 13 |
| creator | Li, Guangdi Liu, Yacong Jing, Xixi Wang, Yali Miao, Miao Tao, Li Zhou, Zhiguo Xie, Yuanlin Huang, Yaxiong Lei, Jianhua Gong, Guozhong Jin, Ping Hao, Yuantao Faria, Nuno Rodrigues Clercq, Erik De Zhang, Min |
| description | The COVID-19 pandemic causes severe morbidity and mortality. This multi-country study aimed to explore risk factors that drive mortality in COVID-19 patients who received neither dexamethasone nor remdesivir. We analyzed a cohort of 568 survivors and 507 non-survivors from China, European regions, and North America. Elderly males ≥70 years accounted for only 25% of survivors, but this rate was significantly higher in non-survivors from China (55%), European regions (63%), and North America (47%). Compared with survivors, non-survivors had more incidences of comorbidities such as cerebrovascular disease and chronic obstructive pulmonary disease (COPD, p-values |
| doi_str_mv | 10.18632/aging.202456 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7835001</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2479747308</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-fecccec2ae74518ba2d40768a9b7185d79e5dcbc79de1fca4048e8665582a3753</originalsourceid><addsrcrecordid>eNpVkc1P7SAQxYl5xu-lW8PybapQoFAXJuY-vxKNG3VLKJ1eUVoU6DP97228anQ1k8wvZ87MQWifkkOqKlYemaUbloclKbmo1tAWrbkouFD1nx_9JtpO6YmQSghebaBNxrgsaSW30P1NiNl4lyccXXrGocOL24erfwWtsRsw-Bain3BvPCT85vIjtqEPsXGtyw7SMTa4H312hQ3jkOOEUx7baRetd8Yn2PusO-j-_OxucVlc315cLU6vC8uUzEUH1lqwpQHJBVWNKVtOZKVM3UiqRCtrEK1trKxboJ01nHAFqpqvUKVhUrAddLLSfRmbHloLswXj9Ut0vYmTDsbp35PBPepl-K-lYoIQOgv8_RSI4XWElHXvkgXvzQBhTLrkspZcMqJmtFihNoaUInTfayjRH1Hojyj0KoqZP_jp7Zv--j17B8Fchwo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2479747308</pqid></control><display><type>article</type><title>Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Li, Guangdi ; Liu, Yacong ; Jing, Xixi ; Wang, Yali ; Miao, Miao ; Tao, Li ; Zhou, Zhiguo ; Xie, Yuanlin ; Huang, Yaxiong ; Lei, Jianhua ; Gong, Guozhong ; Jin, Ping ; Hao, Yuantao ; Faria, Nuno Rodrigues ; Clercq, Erik De ; Zhang, Min</creator><creatorcontrib>Li, Guangdi ; Liu, Yacong ; Jing, Xixi ; Wang, Yali ; Miao, Miao ; Tao, Li ; Zhou, Zhiguo ; Xie, Yuanlin ; Huang, Yaxiong ; Lei, Jianhua ; Gong, Guozhong ; Jin, Ping ; Hao, Yuantao ; Faria, Nuno Rodrigues ; Clercq, Erik De ; Zhang, Min</creatorcontrib><description>The COVID-19 pandemic causes severe morbidity and mortality. This multi-country study aimed to explore risk factors that drive mortality in COVID-19 patients who received neither dexamethasone nor remdesivir. We analyzed a cohort of 568 survivors and 507 non-survivors from China, European regions, and North America. Elderly males ≥70 years accounted for only 25% of survivors, but this rate was significantly higher in non-survivors from China (55%), European regions (63%), and North America (47%). Compared with survivors, non-survivors had more incidences of comorbidities such as cerebrovascular disease and chronic obstructive pulmonary disease (COPD, p-values<0.05). Survival analyses revealed age, male gender, shortness of breath, cerebrovascular disease, and COPD as mortality-associated factors. Survival time from symptom onset was significantly shorter in elderly versus young patients (median: 29 versus 62 days), males versus females (median: 46 versus 59 days), and patients with versus without comorbidities (mean: 41 versus 61 days). Mortality risk was higher in elderly males with comorbidities than in young females without comorbidities (p-value<0.01). Elderly male survivors with comorbidities also had longer hospital stays than other survivors (25 versus 18.5 days, p-value<0.01). Overall, the high mortality risk in elderly males with COVID-19-associated comorbidities supports early prevention and critical care for elderly populations.</description><identifier>ISSN: 1945-4589</identifier><identifier>EISSN: 1945-4589</identifier><identifier>DOI: 10.18632/aging.202456</identifier><identifier>PMID: 33472167</identifier><language>eng</language><publisher>United States: Impact Journals</publisher><subject>Adolescent ; Adult ; Aged ; Aging ; Cardiovascular Diseases - complications ; Cerebrovascular Disorders - complications ; Child ; Child, Preschool ; Cohort Studies ; Comorbidity ; COVID-19 - complications ; COVID-19 - epidemiology ; COVID-19 - mortality ; Female ; Global Health ; Humans ; Infant ; Liver Diseases - complications ; Male ; Middle Aged ; Pulmonary Disease, Chronic Obstructive - complications ; Research Paper ; Respiratory Tract Diseases - complications ; Risk Factors ; SARS-CoV-2 ; Tuberculosis - complications ; Young Adult</subject><ispartof>Aging (Albany, NY.), 2021-01, Vol.13 (1), p.27-60</ispartof><rights>Copyright: © 2020 Wen et al.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-fecccec2ae74518ba2d40768a9b7185d79e5dcbc79de1fca4048e8665582a3753</citedby><cites>FETCH-LOGICAL-c387t-fecccec2ae74518ba2d40768a9b7185d79e5dcbc79de1fca4048e8665582a3753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835001/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835001/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33472167$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Guangdi</creatorcontrib><creatorcontrib>Liu, Yacong</creatorcontrib><creatorcontrib>Jing, Xixi</creatorcontrib><creatorcontrib>Wang, Yali</creatorcontrib><creatorcontrib>Miao, Miao</creatorcontrib><creatorcontrib>Tao, Li</creatorcontrib><creatorcontrib>Zhou, Zhiguo</creatorcontrib><creatorcontrib>Xie, Yuanlin</creatorcontrib><creatorcontrib>Huang, Yaxiong</creatorcontrib><creatorcontrib>Lei, Jianhua</creatorcontrib><creatorcontrib>Gong, Guozhong</creatorcontrib><creatorcontrib>Jin, Ping</creatorcontrib><creatorcontrib>Hao, Yuantao</creatorcontrib><creatorcontrib>Faria, Nuno Rodrigues</creatorcontrib><creatorcontrib>Clercq, Erik De</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><title>Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study</title><title>Aging (Albany, NY.)</title><addtitle>Aging (Albany NY)</addtitle><description>The COVID-19 pandemic causes severe morbidity and mortality. This multi-country study aimed to explore risk factors that drive mortality in COVID-19 patients who received neither dexamethasone nor remdesivir. We analyzed a cohort of 568 survivors and 507 non-survivors from China, European regions, and North America. Elderly males ≥70 years accounted for only 25% of survivors, but this rate was significantly higher in non-survivors from China (55%), European regions (63%), and North America (47%). Compared with survivors, non-survivors had more incidences of comorbidities such as cerebrovascular disease and chronic obstructive pulmonary disease (COPD, p-values<0.05). Survival analyses revealed age, male gender, shortness of breath, cerebrovascular disease, and COPD as mortality-associated factors. Survival time from symptom onset was significantly shorter in elderly versus young patients (median: 29 versus 62 days), males versus females (median: 46 versus 59 days), and patients with versus without comorbidities (mean: 41 versus 61 days). Mortality risk was higher in elderly males with comorbidities than in young females without comorbidities (p-value<0.01). Elderly male survivors with comorbidities also had longer hospital stays than other survivors (25 versus 18.5 days, p-value<0.01). Overall, the high mortality risk in elderly males with COVID-19-associated comorbidities supports early prevention and critical care for elderly populations.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Cardiovascular Diseases - complications</subject><subject>Cerebrovascular Disorders - complications</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Cohort Studies</subject><subject>Comorbidity</subject><subject>COVID-19 - complications</subject><subject>COVID-19 - epidemiology</subject><subject>COVID-19 - mortality</subject><subject>Female</subject><subject>Global Health</subject><subject>Humans</subject><subject>Infant</subject><subject>Liver Diseases - complications</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Pulmonary Disease, Chronic Obstructive - complications</subject><subject>Research Paper</subject><subject>Respiratory Tract Diseases - complications</subject><subject>Risk Factors</subject><subject>SARS-CoV-2</subject><subject>Tuberculosis - complications</subject><subject>Young Adult</subject><issn>1945-4589</issn><issn>1945-4589</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkc1P7SAQxYl5xu-lW8PybapQoFAXJuY-vxKNG3VLKJ1eUVoU6DP97228anQ1k8wvZ87MQWifkkOqKlYemaUbloclKbmo1tAWrbkouFD1nx_9JtpO6YmQSghebaBNxrgsaSW30P1NiNl4lyccXXrGocOL24erfwWtsRsw-Bain3BvPCT85vIjtqEPsXGtyw7SMTa4H312hQ3jkOOEUx7baRetd8Yn2PusO-j-_OxucVlc315cLU6vC8uUzEUH1lqwpQHJBVWNKVtOZKVM3UiqRCtrEK1trKxboJ01nHAFqpqvUKVhUrAddLLSfRmbHloLswXj9Ut0vYmTDsbp35PBPepl-K-lYoIQOgv8_RSI4XWElHXvkgXvzQBhTLrkspZcMqJmtFihNoaUInTfayjRH1Hojyj0KoqZP_jp7Zv--j17B8Fchwo</recordid><startdate>20210115</startdate><enddate>20210115</enddate><creator>Li, Guangdi</creator><creator>Liu, Yacong</creator><creator>Jing, Xixi</creator><creator>Wang, Yali</creator><creator>Miao, Miao</creator><creator>Tao, Li</creator><creator>Zhou, Zhiguo</creator><creator>Xie, Yuanlin</creator><creator>Huang, Yaxiong</creator><creator>Lei, Jianhua</creator><creator>Gong, Guozhong</creator><creator>Jin, Ping</creator><creator>Hao, Yuantao</creator><creator>Faria, Nuno Rodrigues</creator><creator>Clercq, Erik De</creator><creator>Zhang, Min</creator><general>Impact Journals</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20210115</creationdate><title>Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study</title><author>Li, Guangdi ; Liu, Yacong ; Jing, Xixi ; Wang, Yali ; Miao, Miao ; Tao, Li ; Zhou, Zhiguo ; Xie, Yuanlin ; Huang, Yaxiong ; Lei, Jianhua ; Gong, Guozhong ; Jin, Ping ; Hao, Yuantao ; Faria, Nuno Rodrigues ; Clercq, Erik De ; Zhang, Min</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-fecccec2ae74518ba2d40768a9b7185d79e5dcbc79de1fca4048e8665582a3753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Cardiovascular Diseases - complications</topic><topic>Cerebrovascular Disorders - complications</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Cohort Studies</topic><topic>Comorbidity</topic><topic>COVID-19 - complications</topic><topic>COVID-19 - epidemiology</topic><topic>COVID-19 - mortality</topic><topic>Female</topic><topic>Global Health</topic><topic>Humans</topic><topic>Infant</topic><topic>Liver Diseases - complications</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Pulmonary Disease, Chronic Obstructive - complications</topic><topic>Research Paper</topic><topic>Respiratory Tract Diseases - complications</topic><topic>Risk Factors</topic><topic>SARS-CoV-2</topic><topic>Tuberculosis - complications</topic><topic>Young Adult</topic><toplevel>online_resources</toplevel><creatorcontrib>Li, Guangdi</creatorcontrib><creatorcontrib>Liu, Yacong</creatorcontrib><creatorcontrib>Jing, Xixi</creatorcontrib><creatorcontrib>Wang, Yali</creatorcontrib><creatorcontrib>Miao, Miao</creatorcontrib><creatorcontrib>Tao, Li</creatorcontrib><creatorcontrib>Zhou, Zhiguo</creatorcontrib><creatorcontrib>Xie, Yuanlin</creatorcontrib><creatorcontrib>Huang, Yaxiong</creatorcontrib><creatorcontrib>Lei, Jianhua</creatorcontrib><creatorcontrib>Gong, Guozhong</creatorcontrib><creatorcontrib>Jin, Ping</creatorcontrib><creatorcontrib>Hao, Yuantao</creatorcontrib><creatorcontrib>Faria, Nuno Rodrigues</creatorcontrib><creatorcontrib>Clercq, Erik De</creatorcontrib><creatorcontrib>Zhang, Min</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Aging (Albany, NY.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Guangdi</au><au>Liu, Yacong</au><au>Jing, Xixi</au><au>Wang, Yali</au><au>Miao, Miao</au><au>Tao, Li</au><au>Zhou, Zhiguo</au><au>Xie, Yuanlin</au><au>Huang, Yaxiong</au><au>Lei, Jianhua</au><au>Gong, Guozhong</au><au>Jin, Ping</au><au>Hao, Yuantao</au><au>Faria, Nuno Rodrigues</au><au>Clercq, Erik De</au><au>Zhang, Min</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study</atitle><jtitle>Aging (Albany, NY.)</jtitle><addtitle>Aging (Albany NY)</addtitle><date>2021-01-15</date><risdate>2021</risdate><volume>13</volume><issue>1</issue><spage>27</spage><epage>60</epage><pages>27-60</pages><issn>1945-4589</issn><eissn>1945-4589</eissn><abstract>The COVID-19 pandemic causes severe morbidity and mortality. This multi-country study aimed to explore risk factors that drive mortality in COVID-19 patients who received neither dexamethasone nor remdesivir. We analyzed a cohort of 568 survivors and 507 non-survivors from China, European regions, and North America. Elderly males ≥70 years accounted for only 25% of survivors, but this rate was significantly higher in non-survivors from China (55%), European regions (63%), and North America (47%). Compared with survivors, non-survivors had more incidences of comorbidities such as cerebrovascular disease and chronic obstructive pulmonary disease (COPD, p-values<0.05). Survival analyses revealed age, male gender, shortness of breath, cerebrovascular disease, and COPD as mortality-associated factors. Survival time from symptom onset was significantly shorter in elderly versus young patients (median: 29 versus 62 days), males versus females (median: 46 versus 59 days), and patients with versus without comorbidities (mean: 41 versus 61 days). Mortality risk was higher in elderly males with comorbidities than in young females without comorbidities (p-value<0.01). Elderly male survivors with comorbidities also had longer hospital stays than other survivors (25 versus 18.5 days, p-value<0.01). Overall, the high mortality risk in elderly males with COVID-19-associated comorbidities supports early prevention and critical care for elderly populations.</abstract><cop>United States</cop><pub>Impact Journals</pub><pmid>33472167</pmid><doi>10.18632/aging.202456</doi><tpages>34</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1945-4589 |
| ispartof | Aging (Albany, NY.), 2021-01, Vol.13 (1), p.27-60 |
| issn | 1945-4589 1945-4589 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7835001 |
| source | MEDLINE; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Adolescent Adult Aged Aging Cardiovascular Diseases - complications Cerebrovascular Disorders - complications Child Child, Preschool Cohort Studies Comorbidity COVID-19 - complications COVID-19 - epidemiology COVID-19 - mortality Female Global Health Humans Infant Liver Diseases - complications Male Middle Aged Pulmonary Disease, Chronic Obstructive - complications Research Paper Respiratory Tract Diseases - complications Risk Factors SARS-CoV-2 Tuberculosis - complications Young Adult |
| title | Mortality risk of COVID-19 in elderly males with comorbidities: a multi-country study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-22T06%3A56%3A14IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Mortality%20risk%20of%20COVID-19%20in%20elderly%20males%20with%20comorbidities:%20a%20multi-country%20study&rft.jtitle=Aging%20(Albany,%20NY.)&rft.au=Li,%20Guangdi&rft.date=2021-01-15&rft.volume=13&rft.issue=1&rft.spage=27&rft.epage=60&rft.pages=27-60&rft.issn=1945-4589&rft.eissn=1945-4589&rft_id=info:doi/10.18632/aging.202456&rft_dat=%3Cproquest_pubme%3E2479747308%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2479747308&rft_id=info:pmid/33472167&rfr_iscdi=true |