P2X7 Receptor Induces Pyroptotic Inflammation and Cartilage Degradation in Osteoarthritis via NF-κB/NLRP3 Crosstalk

Osteoarthritis (OA) is an urgent public health problem; however, the underlying causal mechanisms remain unclear, especially in terms of inflammatory mediators in cartilage degradation and chondrocyte imbalance. P2X7 receptor (P2X7R) is a critical inflammation switch, but few studies have examined i...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2021, Vol.2021 (1), p.8868361
Hauptverfasser:	Li, Zihao, Huang, Ziyu, Zhang, He, Lu, Jinghan, Tian, Yicheng, Wei, Yingliang, Yang, Yue, Bai, Lunhao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphate Arthritis Cartilage Collagen Experiments Extracellular matrix Gene expression Inflammation Osteoarthritis Proteins Reactive oxygen species Tumor necrosis factor-TNF
Online-Zugang:	Volltext
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