How would you like your COVID-19? From a host with mild course disease, or from a severe one?
The clinical course of COVID-19 presents a broad spectrum, being asymptomatic in some individuals while following a severe course and resulting in mortality in others. It is known that such factors as age and chronic diseases can result in a different clinical courses in individuals, however, variab...
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| Veröffentlicht in: | The American journal of emergency medicine 2020-11, Vol.38 (11), p.2487.e7-2487.e12 |
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| container_issue | 11 |
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| container_title | The American journal of emergency medicine |
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| creator | Yamanoglu, Adnan Akyol, Pinar Yeşim Acar, Hüseyin Celebi Yamanoglu, Nalan Gokce Topal, Fatih Esad Kayalı, Ahmet |
| description | The clinical course of COVID-19 presents a broad spectrum, being asymptomatic in some individuals while following a severe course and resulting in mortality in others. It is known that such factors as age and chronic diseases can result in a different clinical courses in individuals, however, variable clinical courses among the similar individuals in terms of age and chronic diseases are also seen. Other possible factors affecting the course of the disease that are mostly speculative or under investigation are genetic factors and the origin of transmission or possible subtype of novel coronavirus. Whether the source of transmission is important in the clinical course of the disease is unknown.
A case series composed of seven individuals in a similar age group, with different lines of descent and different genetic structures, but who were infected from the same source is presented here. The similar and different clinical, laboratory and radiological findings of the cases residing in the same nursing home, who presented to the hospital altogether, were evaluated. The aim of the study was to analyze whether the source of transmission is influential in the clinical course of the disease. |
| doi_str_mv | 10.1016/j.ajem.2020.05.091 |
| format | Article |
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A case series composed of seven individuals in a similar age group, with different lines of descent and different genetic structures, but who were infected from the same source is presented here. The similar and different clinical, laboratory and radiological findings of the cases residing in the same nursing home, who presented to the hospital altogether, were evaluated. The aim of the study was to analyze whether the source of transmission is influential in the clinical course of the disease.</description><identifier>ISSN: 0735-6757</identifier><identifier>ISSN: 1532-8171</identifier><identifier>EISSN: 1532-8171</identifier><identifier>DOI: 10.1016/j.ajem.2020.05.091</identifier><identifier>PMID: 32536478</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acidosis ; Age ; Aged ; Aged, 80 and over ; Blood groups ; Case Report ; Chronic illnesses ; Comorbidity ; Coronaviruses ; COVID-19 ; COVID-19 - diagnosis ; COVID-19 - genetics ; COVID-19 - physiopathology ; Disease transmission ; Emergency medical care ; Epidemics ; Female ; Genetic factors ; Genotype ; Hospitals ; Host factor in COVID-19 ; Humans ; Laboratories ; Male ; Novel coronavirus ; Nursing homes ; Patients ; Phenotype ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Severity of Illness Index ; Source of coronavirus ; Subtypes of novel coronavirus ; Thrombocytopenia ; Turkey ; Vaccines ; Viral infections ; Viruses</subject><ispartof>The American journal of emergency medicine, 2020-11, Vol.38 (11), p.2487.e7-2487.e12</ispartof><rights>2020 Elsevier Inc.</rights><rights>Copyright © 2020 Elsevier Inc. All rights reserved.</rights><rights>2020. Elsevier Inc.</rights><rights>2020 Elsevier Inc. All rights reserved. 2020 Elsevier Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c483t-a4bc2c67969831808f6589a9d3177a701017e46edd02e69fd0ab68c1560f4b553</citedby><cites>FETCH-LOGICAL-c483t-a4bc2c67969831808f6589a9d3177a701017e46edd02e69fd0ab68c1560f4b553</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2467610878?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32536478$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yamanoglu, Adnan</creatorcontrib><creatorcontrib>Akyol, Pinar Yeşim</creatorcontrib><creatorcontrib>Acar, Hüseyin</creatorcontrib><creatorcontrib>Celebi Yamanoglu, Nalan Gokce</creatorcontrib><creatorcontrib>Topal, Fatih Esad</creatorcontrib><creatorcontrib>Kayalı, Ahmet</creatorcontrib><title>How would you like your COVID-19? From a host with mild course disease, or from a severe one?</title><title>The American journal of emergency medicine</title><addtitle>Am J Emerg Med</addtitle><description>The clinical course of COVID-19 presents a broad spectrum, being asymptomatic in some individuals while following a severe course and resulting in mortality in others. It is known that such factors as age and chronic diseases can result in a different clinical courses in individuals, however, variable clinical courses among the similar individuals in terms of age and chronic diseases are also seen. Other possible factors affecting the course of the disease that are mostly speculative or under investigation are genetic factors and the origin of transmission or possible subtype of novel coronavirus. Whether the source of transmission is important in the clinical course of the disease is unknown.
A case series composed of seven individuals in a similar age group, with different lines of descent and different genetic structures, but who were infected from the same source is presented here. The similar and different clinical, laboratory and radiological findings of the cases residing in the same nursing home, who presented to the hospital altogether, were evaluated. The aim of the study was to analyze whether the source of transmission is influential in the clinical course of the disease.</description><subject>Acidosis</subject><subject>Age</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Blood groups</subject><subject>Case Report</subject><subject>Chronic illnesses</subject><subject>Comorbidity</subject><subject>Coronaviruses</subject><subject>COVID-19</subject><subject>COVID-19 - diagnosis</subject><subject>COVID-19 - genetics</subject><subject>COVID-19 - physiopathology</subject><subject>Disease transmission</subject><subject>Emergency medical care</subject><subject>Epidemics</subject><subject>Female</subject><subject>Genetic factors</subject><subject>Genotype</subject><subject>Hospitals</subject><subject>Host factor in COVID-19</subject><subject>Humans</subject><subject>Laboratories</subject><subject>Male</subject><subject>Novel coronavirus</subject><subject>Nursing homes</subject><subject>Patients</subject><subject>Phenotype</subject><subject>SARS-CoV-2</subject><subject>Severe acute respiratory syndrome coronavirus 2</subject><subject>Severity of Illness Index</subject><subject>Source of coronavirus</subject><subject>Subtypes of novel coronavirus</subject><subject>Thrombocytopenia</subject><subject>Turkey</subject><subject>Vaccines</subject><subject>Viral infections</subject><subject>Viruses</subject><issn>0735-6757</issn><issn>1532-8171</issn><issn>1532-8171</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp9kV1rFDEUhoModl39A15IwBsvnDEfky8Qi2ytLRR6o95JyGbOuFlnJjWZ2aX_vlm2FvXCqwTynJe850HoJSU1JVS-29ZuC0PNCCM1ETUx9BFaUMFZpamij9GCKC4qqYQ6Qc9y3hJCaSOap-iEM8Flo_QCfb-Ie7yPc9_i2zjjPvyEwyXh1fW3y7OKmlN8nuKAHd7EPOF9mDZ4CIX2BcqA25DBZXiLY8LdEcywgwQ4jnD6HD3pXJ_hxf25RF_PP31ZXVRX158vVx-vKt9oPlWuWXvmpTLSaE410Z0U2jjTcqqUU6S0VdBIaFvCQJquJW4ttadCkq5ZC8GX6MMx92ZeD9B6GKfkenuTwuDSrY0u2L9fxrCxP-LOKs0byVQJeHMfkOKvGfJkh5A99L0bIc7ZsoZyY4xksqCv_0G3ZRVjqVcoqSQluqQuETtSPsWcE3QPn6HEHuzZrT3Yswd7lghb7JWhV3_WeBj5rasA748AlGXuAiSbfYDRQxsS-Mm2Mfwv_w78D6lR</recordid><startdate>20201101</startdate><enddate>20201101</enddate><creator>Yamanoglu, Adnan</creator><creator>Akyol, Pinar Yeşim</creator><creator>Acar, Hüseyin</creator><creator>Celebi Yamanoglu, Nalan Gokce</creator><creator>Topal, Fatih Esad</creator><creator>Kayalı, Ahmet</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20201101</creationdate><title>How would you like your COVID-19? 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From a host with mild course disease, or from a severe one?</atitle><jtitle>The American journal of emergency medicine</jtitle><addtitle>Am J Emerg Med</addtitle><date>2020-11-01</date><risdate>2020</risdate><volume>38</volume><issue>11</issue><spage>2487.e7</spage><epage>2487.e12</epage><pages>2487.e7-2487.e12</pages><issn>0735-6757</issn><issn>1532-8171</issn><eissn>1532-8171</eissn><abstract>The clinical course of COVID-19 presents a broad spectrum, being asymptomatic in some individuals while following a severe course and resulting in mortality in others. It is known that such factors as age and chronic diseases can result in a different clinical courses in individuals, however, variable clinical courses among the similar individuals in terms of age and chronic diseases are also seen. Other possible factors affecting the course of the disease that are mostly speculative or under investigation are genetic factors and the origin of transmission or possible subtype of novel coronavirus. Whether the source of transmission is important in the clinical course of the disease is unknown.
A case series composed of seven individuals in a similar age group, with different lines of descent and different genetic structures, but who were infected from the same source is presented here. The similar and different clinical, laboratory and radiological findings of the cases residing in the same nursing home, who presented to the hospital altogether, were evaluated. The aim of the study was to analyze whether the source of transmission is influential in the clinical course of the disease.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>32536478</pmid><doi>10.1016/j.ajem.2020.05.091</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | The American journal of emergency medicine, 2020-11, Vol.38 (11), p.2487.e7-2487.e12 |
| issn | 0735-6757 1532-8171 1532-8171 |
| language | eng |
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| subjects | Acidosis Age Aged Aged, 80 and over Blood groups Case Report Chronic illnesses Comorbidity Coronaviruses COVID-19 COVID-19 - diagnosis COVID-19 - genetics COVID-19 - physiopathology Disease transmission Emergency medical care Epidemics Female Genetic factors Genotype Hospitals Host factor in COVID-19 Humans Laboratories Male Novel coronavirus Nursing homes Patients Phenotype SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Severity of Illness Index Source of coronavirus Subtypes of novel coronavirus Thrombocytopenia Turkey Vaccines Viral infections Viruses |
| title | How would you like your COVID-19? From a host with mild course disease, or from a severe one? |
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