Addressing the Cold Reality of mRNA Vaccine Stability

As mRNA vaccines became the frontrunners in late-stage clinical trials to fight the COVID-19 pandemic, challenges surrounding their formulation and stability became readily apparent. In this commentary, we first describe company proposals, based on available public information, for the (frozen) stor...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2021-03, Vol.110 (3), p.997-1001
Hauptverfasser:	Crommelin, Daan J.A., Anchordoquy, Thomas J., Volkin, David B., Jiskoot, Wim, Mastrobattista, Enrico
Format:	Artikel
Sprache:	eng
Schlagworte:	2019-nCoV Vaccine mRNA-1273 BNT162 Vaccine Cold chain Cold Temperature COVID-19 COVID-19 - immunology COVID-19 - prevention & control COVID-19 Vaccines - chemistry COVID-19 Vaccines - immunology Drug Stability Drug Storage - methods Formulation Humans Lipid nanoparticles mRNA mRNA Vaccines RNA Stability RNA, Messenger - chemistry RNA, Messenger - immunology SARS-CoV-2 - immunology Shelf life Special Topic Stability Vaccine Vaccine Potency Vaccines, Synthetic - chemistry Vaccines, Synthetic - immunology
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