A Micellar Formulation of Quercetin Prevents Cisplatin Nephrotoxicity

The antioxidant flavonoid quercetin has been shown to prevent nephrotoxicity in animal models and in a clinical study and is thus a very promising prophylactic candidate under development. Quercetin solubility is very low, which handicaps clinical application. The aim of this work was to study, in r...

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Veröffentlicht in:	International journal of molecular sciences 2021-01, Vol.22 (2), p.729
Hauptverfasser:	Casanova, Alfredo G, Prieto, Marta, Colino, Clara I, Gutiérrez-Millán, Carmen, Ruszkowska-Ciastek, Barbara, de Paz, Esther, Martín, Ángel, Morales, Ana I, López-Hernández, Francisco J
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Antineoplastic Agents - adverse effects Antioxidants Antioxidants - chemistry Antioxidants - pharmacology Bioavailability Biological Availability Biomarkers Chemotherapy Cisplatin Cisplatin - adverse effects Creatinine Cytotoxicity Drug Compounding Drug dosages Flavonoids Immunohistochemistry Kidney - drug effects Kidney - metabolism Kidney - pathology Kidney Function Tests Kidneys Micelles Oxidative stress Pharmaceuticals Plasma Poloxamers Protective Agents - chemistry Protective Agents - pharmacology Quercetin Quercetin - chemistry Quercetin - pharmacology Renal function Solubility Urea
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