Molecular Epidemiology of the Main Druggable Genetic Alterations in Non-Small Cell Lung Cancer
Lung cancer is the leading cause of death for malignancy worldwide. Its molecular profiling has enriched our understanding of cancer initiation and progression and has become fundamental to provide guidance on treatment with targeted therapies. Testing the presence of driver mutations in specific ge...
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| Veröffentlicht in: | International journal of molecular sciences 2021-01, Vol.22 (2), p.612 |
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| creator | Fois, Sara S Paliogiannis, Panagiotis Zinellu, Angelo Fois, Alessandro G Cossu, Antonio Palmieri, Giuseppe |
| description | Lung cancer is the leading cause of death for malignancy worldwide. Its molecular profiling has enriched our understanding of cancer initiation and progression and has become fundamental to provide guidance on treatment with targeted therapies. Testing the presence of driver mutations in specific genes in lung tumors has thus radically changed the clinical management and outcomes of the disease. Numerous studies performed with traditional sequencing methods have investigated the occurrence of such mutations in lung cancer, and new insights regarding their frequency and clinical significance are continuously provided with the use of last generation sequencing technologies. In this review, we discuss the molecular epidemiology of the main druggable genetic alterations in non-small cell lung cancer, namely
,
,
,
, and
mutations or amplification, as well as
and
fusions. Furthermore, we investigated the predictive impact of these alterations on the outcomes of modern targeted therapies, their global prognostic significance, and their mutual interaction in cases of co-occurrence. |
| doi_str_mv | 10.3390/ijms22020612 |
| format | Article |
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,
,
,
, and
mutations or amplification, as well as
and
fusions. Furthermore, we investigated the predictive impact of these alterations on the outcomes of modern targeted therapies, their global prognostic significance, and their mutual interaction in cases of co-occurrence.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22020612</identifier><identifier>PMID: 33435440</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Carcinoma, Non-Small-Cell Lung - drug therapy ; Carcinoma, Non-Small-Cell Lung - epidemiology ; Carcinoma, Non-Small-Cell Lung - genetics ; Epidemiology ; Epidermal growth factor receptors ; ErbB-2 protein ; Gene Amplification - drug effects ; Gene Expression Regulation, Neoplastic - drug effects ; Humans ; Impact prediction ; Kinases ; Lung cancer ; Lung Neoplasms - drug therapy ; Lung Neoplasms - epidemiology ; Lung Neoplasms - genetics ; Malignancy ; Molecular Epidemiology ; Molecular Targeted Therapy ; Mortality ; Mutation ; Mutation - drug effects ; Non-small cell lung carcinoma ; Oncogene Proteins, Fusion - genetics ; Review ; Tumors</subject><ispartof>International journal of molecular sciences, 2021-01, Vol.22 (2), p.612</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-5eb2998b5849a17717683a540ec01c7bde3b910ca73379332f67e78f1dfbca5f3</citedby><cites>FETCH-LOGICAL-c412t-5eb2998b5849a17717683a540ec01c7bde3b910ca73379332f67e78f1dfbca5f3</cites><orcidid>0000-0001-5485-6056 ; 0000-0003-2513-7006 ; 0000-0002-8396-0968 ; 0000-0002-4350-2276 ; 0000-0001-5330-572X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827915/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7827915/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33435440$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fois, Sara S</creatorcontrib><creatorcontrib>Paliogiannis, Panagiotis</creatorcontrib><creatorcontrib>Zinellu, Angelo</creatorcontrib><creatorcontrib>Fois, Alessandro G</creatorcontrib><creatorcontrib>Cossu, Antonio</creatorcontrib><creatorcontrib>Palmieri, Giuseppe</creatorcontrib><title>Molecular Epidemiology of the Main Druggable Genetic Alterations in Non-Small Cell Lung Cancer</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Lung cancer is the leading cause of death for malignancy worldwide. Its molecular profiling has enriched our understanding of cancer initiation and progression and has become fundamental to provide guidance on treatment with targeted therapies. Testing the presence of driver mutations in specific genes in lung tumors has thus radically changed the clinical management and outcomes of the disease. Numerous studies performed with traditional sequencing methods have investigated the occurrence of such mutations in lung cancer, and new insights regarding their frequency and clinical significance are continuously provided with the use of last generation sequencing technologies. In this review, we discuss the molecular epidemiology of the main druggable genetic alterations in non-small cell lung cancer, namely
,
,
,
, and
mutations or amplification, as well as
and
fusions. Furthermore, we investigated the predictive impact of these alterations on the outcomes of modern targeted therapies, their global prognostic significance, and their mutual interaction in cases of co-occurrence.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Carcinoma, Non-Small-Cell Lung - drug therapy</subject><subject>Carcinoma, Non-Small-Cell Lung - epidemiology</subject><subject>Carcinoma, Non-Small-Cell Lung - genetics</subject><subject>Epidemiology</subject><subject>Epidermal growth factor receptors</subject><subject>ErbB-2 protein</subject><subject>Gene Amplification - drug effects</subject><subject>Gene Expression Regulation, Neoplastic - drug effects</subject><subject>Humans</subject><subject>Impact prediction</subject><subject>Kinases</subject><subject>Lung cancer</subject><subject>Lung Neoplasms - drug therapy</subject><subject>Lung Neoplasms - epidemiology</subject><subject>Lung Neoplasms - genetics</subject><subject>Malignancy</subject><subject>Molecular Epidemiology</subject><subject>Molecular Targeted Therapy</subject><subject>Mortality</subject><subject>Mutation</subject><subject>Mutation - drug effects</subject><subject>Non-small cell lung carcinoma</subject><subject>Oncogene Proteins, Fusion - genetics</subject><subject>Review</subject><subject>Tumors</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUtr3DAUhUVpaR7tLusg6KaLuNHLlrUphGmSFibpIum2QtZcOxpkaSLZgfz7KI-GaTb3Xrgfh3M4CB1Q8o1zRY7desyMEUYayt6hXSoYqwhp5Putewft5bwmhHFWq49oh3PBayHILvp7ET3Y2ZuETzduBaOLPg73OPZ4ugF8YVzAP9I8DKbzgM8hwOQsPvETJDO5GDIuwGUM1dVovMcLKGM5hwEvTLCQPqEPvfEZPr_sffTn7PR68bNa_j7_tThZVlZQNlU1dEyptqtboQyVksqm5aYWBCyhVnYr4J2ixBrJuVScs76RINuervrOmrrn--j7s-5m7kZYWQhTMl5vkhtNutfROP3_J7gbPcQ7LVsmFa2LwNcXgRRvZ8iTHl22JY0JEOesmZBSKNkoWtAvb9B1nFMo8Z6otvhvZaGOnimbYs4J-lczlOjH4vR2cQU_3A7wCv9rij8A0meT8A</recordid><startdate>20210109</startdate><enddate>20210109</enddate><creator>Fois, Sara S</creator><creator>Paliogiannis, Panagiotis</creator><creator>Zinellu, Angelo</creator><creator>Fois, Alessandro G</creator><creator>Cossu, Antonio</creator><creator>Palmieri, Giuseppe</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5485-6056</orcidid><orcidid>https://orcid.org/0000-0003-2513-7006</orcidid><orcidid>https://orcid.org/0000-0002-8396-0968</orcidid><orcidid>https://orcid.org/0000-0002-4350-2276</orcidid><orcidid>https://orcid.org/0000-0001-5330-572X</orcidid></search><sort><creationdate>20210109</creationdate><title>Molecular Epidemiology of the Main Druggable Genetic Alterations in Non-Small Cell Lung Cancer</title><author>Fois, Sara S ; 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Its molecular profiling has enriched our understanding of cancer initiation and progression and has become fundamental to provide guidance on treatment with targeted therapies. Testing the presence of driver mutations in specific genes in lung tumors has thus radically changed the clinical management and outcomes of the disease. Numerous studies performed with traditional sequencing methods have investigated the occurrence of such mutations in lung cancer, and new insights regarding their frequency and clinical significance are continuously provided with the use of last generation sequencing technologies. In this review, we discuss the molecular epidemiology of the main druggable genetic alterations in non-small cell lung cancer, namely
,
,
,
, and
mutations or amplification, as well as
and
fusions. Furthermore, we investigated the predictive impact of these alterations on the outcomes of modern targeted therapies, their global prognostic significance, and their mutual interaction in cases of co-occurrence.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33435440</pmid><doi>10.3390/ijms22020612</doi><orcidid>https://orcid.org/0000-0001-5485-6056</orcidid><orcidid>https://orcid.org/0000-0003-2513-7006</orcidid><orcidid>https://orcid.org/0000-0002-8396-0968</orcidid><orcidid>https://orcid.org/0000-0002-4350-2276</orcidid><orcidid>https://orcid.org/0000-0001-5330-572X</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | International journal of molecular sciences, 2021-01, Vol.22 (2), p.612 |
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| subjects | Animals Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - epidemiology Carcinoma, Non-Small-Cell Lung - genetics Epidemiology Epidermal growth factor receptors ErbB-2 protein Gene Amplification - drug effects Gene Expression Regulation, Neoplastic - drug effects Humans Impact prediction Kinases Lung cancer Lung Neoplasms - drug therapy Lung Neoplasms - epidemiology Lung Neoplasms - genetics Malignancy Molecular Epidemiology Molecular Targeted Therapy Mortality Mutation Mutation - drug effects Non-small cell lung carcinoma Oncogene Proteins, Fusion - genetics Review Tumors |
| title | Molecular Epidemiology of the Main Druggable Genetic Alterations in Non-Small Cell Lung Cancer |
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