Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols
Celiac disease is an autoimmune disorder characterized by a heightened immune response to gluten proteins in the diet, leading to gastrointestinal symptoms and mucosal damage localized to the small intestine. Despite its prevalence, the only treatment currently available for celiac disease is comple...
Gespeichert in:
| Veröffentlicht in: | International journal of molecular sciences 2021-01, Vol.22 (2), p.595 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 2 |
| container_start_page | 595 |
| container_title | International journal of molecular sciences |
| container_volume | 22 |
| creator | Van Buiten, Charlene B Elias, Ryan J |
| description | Celiac disease is an autoimmune disorder characterized by a heightened immune response to gluten proteins in the diet, leading to gastrointestinal symptoms and mucosal damage localized to the small intestine. Despite its prevalence, the only treatment currently available for celiac disease is complete avoidance of gluten proteins in the diet. Ongoing clinical trials have focused on targeting the immune response or gluten proteins through methods such as immunosuppression, enhanced protein degradation and protein sequestration. Recent studies suggest that polyphenols may elicit protective effects within the celiac disease milieu by disrupting the enzymatic hydrolysis of gluten proteins, sequestering gluten proteins from recognition by critical receptors in pathogenesis and exerting anti-inflammatory effects on the system as a whole. This review highlights mechanisms by which polyphenols can protect against celiac disease, takes a critical look at recent works and outlines future applications for this potential treatment method. |
| doi_str_mv | 10.3390/ijms22020595 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7826989</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2477380439</sourcerecordid><originalsourceid>FETCH-LOGICAL-c412t-9e84c5800b8a88132e8b8d6dc09736973e4e0c275b8f3956baab1e6fc3331b663</originalsourceid><addsrcrecordid>eNpdkUtLAzEURoMovneuJeDGhdVMkskkLoRSnyBaUNchk96xKelkTNpC_73Th1JdhATu4ZDvfgidZOSSMUWu3GicKCWU5CrfQvsZp7RDiCi2N9576CClESGU0Vztoj3GOMtFlu-j6sE7M3A1foOvKaRJNBMXamwSNvglzMDj9yFE08xxFSLuQUtbfOsSmATXuIv7MaQG7MTNAHebxju7EizofvDzZgh18OkI7VTGJzhe34fo4_7uvffYeX59eOp1nzuWZ3TSUSC5zSUhpTRSZoyCLOVADCxRBRPtAQ7E0iIvZcVULkpjygxEZRljWSkEO0Q3K28zLccwsFC3ibxuohubONfBOP13Uruh_gwzXUgqlFSt4HwtiGG5ED12yYL3poYwTZryouCqUJS36Nk_dBSmsW7jLSkmCWcL4cWKsu2mUoTq9zMZ0YsC9WaBLX66GeAX_mmMfQPzS5d0</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2477380439</pqid></control><display><type>article</type><title>Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Van Buiten, Charlene B ; Elias, Ryan J</creator><creatorcontrib>Van Buiten, Charlene B ; Elias, Ryan J</creatorcontrib><description>Celiac disease is an autoimmune disorder characterized by a heightened immune response to gluten proteins in the diet, leading to gastrointestinal symptoms and mucosal damage localized to the small intestine. Despite its prevalence, the only treatment currently available for celiac disease is complete avoidance of gluten proteins in the diet. Ongoing clinical trials have focused on targeting the immune response or gluten proteins through methods such as immunosuppression, enhanced protein degradation and protein sequestration. Recent studies suggest that polyphenols may elicit protective effects within the celiac disease milieu by disrupting the enzymatic hydrolysis of gluten proteins, sequestering gluten proteins from recognition by critical receptors in pathogenesis and exerting anti-inflammatory effects on the system as a whole. This review highlights mechanisms by which polyphenols can protect against celiac disease, takes a critical look at recent works and outlines future applications for this potential treatment method.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms22020595</identifier><identifier>PMID: 33435615</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Autoimmune diseases ; Autoimmune Diseases - immunology ; Autoimmune Diseases - metabolism ; Autoimmune Diseases - prevention & control ; Barley ; Celiac disease ; Celiac Disease - immunology ; Celiac Disease - metabolism ; Celiac Disease - prevention & control ; Chemical bonds ; Chronic illnesses ; Clinical trials ; Cytokines ; Damage localization ; Diet ; Disease ; Enzymes ; Food ; Gastrointestinal symptoms ; Gliadin ; Gliadin - immunology ; Gliadin - metabolism ; Gluten ; Glutens - immunology ; Glutens - metabolism ; Growth factors ; Health services ; Humans ; Immune response ; Immune system ; Immunosuppression ; Immunosuppression - methods ; Inflammation ; Intestinal Mucosa - drug effects ; Intestinal Mucosa - immunology ; Intestinal Mucosa - metabolism ; Intestine ; Intestine, Small - drug effects ; Intestine, Small - immunology ; Intestine, Small - metabolism ; Mucosa ; Pathogenesis ; Peptides ; Permeability ; Polyphenols ; Polyphenols - immunology ; Polyphenols - metabolism ; Polyphenols - therapeutic use ; Prospective Studies ; Proteins ; Review ; Sequestering ; Small intestine</subject><ispartof>International journal of molecular sciences, 2021-01, Vol.22 (2), p.595</ispartof><rights>2021. This work is licensed under http://creativecommons.org/licenses/by/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2021 by the authors. 2021</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c412t-9e84c5800b8a88132e8b8d6dc09736973e4e0c275b8f3956baab1e6fc3331b663</citedby><cites>FETCH-LOGICAL-c412t-9e84c5800b8a88132e8b8d6dc09736973e4e0c275b8f3956baab1e6fc3331b663</cites><orcidid>0000-0001-8416-8772 ; 0000-0001-9613-9100</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826989/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC7826989/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33435615$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Van Buiten, Charlene B</creatorcontrib><creatorcontrib>Elias, Ryan J</creatorcontrib><title>Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols</title><title>International journal of molecular sciences</title><addtitle>Int J Mol Sci</addtitle><description>Celiac disease is an autoimmune disorder characterized by a heightened immune response to gluten proteins in the diet, leading to gastrointestinal symptoms and mucosal damage localized to the small intestine. Despite its prevalence, the only treatment currently available for celiac disease is complete avoidance of gluten proteins in the diet. Ongoing clinical trials have focused on targeting the immune response or gluten proteins through methods such as immunosuppression, enhanced protein degradation and protein sequestration. Recent studies suggest that polyphenols may elicit protective effects within the celiac disease milieu by disrupting the enzymatic hydrolysis of gluten proteins, sequestering gluten proteins from recognition by critical receptors in pathogenesis and exerting anti-inflammatory effects on the system as a whole. This review highlights mechanisms by which polyphenols can protect against celiac disease, takes a critical look at recent works and outlines future applications for this potential treatment method.</description><subject>Autoimmune diseases</subject><subject>Autoimmune Diseases - immunology</subject><subject>Autoimmune Diseases - metabolism</subject><subject>Autoimmune Diseases - prevention & control</subject><subject>Barley</subject><subject>Celiac disease</subject><subject>Celiac Disease - immunology</subject><subject>Celiac Disease - metabolism</subject><subject>Celiac Disease - prevention & control</subject><subject>Chemical bonds</subject><subject>Chronic illnesses</subject><subject>Clinical trials</subject><subject>Cytokines</subject><subject>Damage localization</subject><subject>Diet</subject><subject>Disease</subject><subject>Enzymes</subject><subject>Food</subject><subject>Gastrointestinal symptoms</subject><subject>Gliadin</subject><subject>Gliadin - immunology</subject><subject>Gliadin - metabolism</subject><subject>Gluten</subject><subject>Glutens - immunology</subject><subject>Glutens - metabolism</subject><subject>Growth factors</subject><subject>Health services</subject><subject>Humans</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Immunosuppression</subject><subject>Immunosuppression - methods</subject><subject>Inflammation</subject><subject>Intestinal Mucosa - drug effects</subject><subject>Intestinal Mucosa - immunology</subject><subject>Intestinal Mucosa - metabolism</subject><subject>Intestine</subject><subject>Intestine, Small - drug effects</subject><subject>Intestine, Small - immunology</subject><subject>Intestine, Small - metabolism</subject><subject>Mucosa</subject><subject>Pathogenesis</subject><subject>Peptides</subject><subject>Permeability</subject><subject>Polyphenols</subject><subject>Polyphenols - immunology</subject><subject>Polyphenols - metabolism</subject><subject>Polyphenols - therapeutic use</subject><subject>Prospective Studies</subject><subject>Proteins</subject><subject>Review</subject><subject>Sequestering</subject><subject>Small intestine</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkUtLAzEURoMovneuJeDGhdVMkskkLoRSnyBaUNchk96xKelkTNpC_73Th1JdhATu4ZDvfgidZOSSMUWu3GicKCWU5CrfQvsZp7RDiCi2N9576CClESGU0Vztoj3GOMtFlu-j6sE7M3A1foOvKaRJNBMXamwSNvglzMDj9yFE08xxFSLuQUtbfOsSmATXuIv7MaQG7MTNAHebxju7EizofvDzZgh18OkI7VTGJzhe34fo4_7uvffYeX59eOp1nzuWZ3TSUSC5zSUhpTRSZoyCLOVADCxRBRPtAQ7E0iIvZcVULkpjygxEZRljWSkEO0Q3K28zLccwsFC3ibxuohubONfBOP13Uruh_gwzXUgqlFSt4HwtiGG5ED12yYL3poYwTZryouCqUJS36Nk_dBSmsW7jLSkmCWcL4cWKsu2mUoTq9zMZ0YsC9WaBLX66GeAX_mmMfQPzS5d0</recordid><startdate>20210108</startdate><enddate>20210108</enddate><creator>Van Buiten, Charlene B</creator><creator>Elias, Ryan J</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8416-8772</orcidid><orcidid>https://orcid.org/0000-0001-9613-9100</orcidid></search><sort><creationdate>20210108</creationdate><title>Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols</title><author>Van Buiten, Charlene B ; Elias, Ryan J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c412t-9e84c5800b8a88132e8b8d6dc09736973e4e0c275b8f3956baab1e6fc3331b663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Autoimmune diseases</topic><topic>Autoimmune Diseases - immunology</topic><topic>Autoimmune Diseases - metabolism</topic><topic>Autoimmune Diseases - prevention & control</topic><topic>Barley</topic><topic>Celiac disease</topic><topic>Celiac Disease - immunology</topic><topic>Celiac Disease - metabolism</topic><topic>Celiac Disease - prevention & control</topic><topic>Chemical bonds</topic><topic>Chronic illnesses</topic><topic>Clinical trials</topic><topic>Cytokines</topic><topic>Damage localization</topic><topic>Diet</topic><topic>Disease</topic><topic>Enzymes</topic><topic>Food</topic><topic>Gastrointestinal symptoms</topic><topic>Gliadin</topic><topic>Gliadin - immunology</topic><topic>Gliadin - metabolism</topic><topic>Gluten</topic><topic>Glutens - immunology</topic><topic>Glutens - metabolism</topic><topic>Growth factors</topic><topic>Health services</topic><topic>Humans</topic><topic>Immune response</topic><topic>Immune system</topic><topic>Immunosuppression</topic><topic>Immunosuppression - methods</topic><topic>Inflammation</topic><topic>Intestinal Mucosa - drug effects</topic><topic>Intestinal Mucosa - immunology</topic><topic>Intestinal Mucosa - metabolism</topic><topic>Intestine</topic><topic>Intestine, Small - drug effects</topic><topic>Intestine, Small - immunology</topic><topic>Intestine, Small - metabolism</topic><topic>Mucosa</topic><topic>Pathogenesis</topic><topic>Peptides</topic><topic>Permeability</topic><topic>Polyphenols</topic><topic>Polyphenols - immunology</topic><topic>Polyphenols - metabolism</topic><topic>Polyphenols - therapeutic use</topic><topic>Prospective Studies</topic><topic>Proteins</topic><topic>Review</topic><topic>Sequestering</topic><topic>Small intestine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Van Buiten, Charlene B</creatorcontrib><creatorcontrib>Elias, Ryan J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Van Buiten, Charlene B</au><au>Elias, Ryan J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols</atitle><jtitle>International journal of molecular sciences</jtitle><addtitle>Int J Mol Sci</addtitle><date>2021-01-08</date><risdate>2021</risdate><volume>22</volume><issue>2</issue><spage>595</spage><pages>595-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Celiac disease is an autoimmune disorder characterized by a heightened immune response to gluten proteins in the diet, leading to gastrointestinal symptoms and mucosal damage localized to the small intestine. Despite its prevalence, the only treatment currently available for celiac disease is complete avoidance of gluten proteins in the diet. Ongoing clinical trials have focused on targeting the immune response or gluten proteins through methods such as immunosuppression, enhanced protein degradation and protein sequestration. Recent studies suggest that polyphenols may elicit protective effects within the celiac disease milieu by disrupting the enzymatic hydrolysis of gluten proteins, sequestering gluten proteins from recognition by critical receptors in pathogenesis and exerting anti-inflammatory effects on the system as a whole. This review highlights mechanisms by which polyphenols can protect against celiac disease, takes a critical look at recent works and outlines future applications for this potential treatment method.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>33435615</pmid><doi>10.3390/ijms22020595</doi><orcidid>https://orcid.org/0000-0001-8416-8772</orcidid><orcidid>https://orcid.org/0000-0001-9613-9100</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1422-0067 |
| ispartof | International journal of molecular sciences, 2021-01, Vol.22 (2), p.595 |
| issn | 1422-0067 1661-6596 1422-0067 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_7826989 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | Autoimmune diseases Autoimmune Diseases - immunology Autoimmune Diseases - metabolism Autoimmune Diseases - prevention & control Barley Celiac disease Celiac Disease - immunology Celiac Disease - metabolism Celiac Disease - prevention & control Chemical bonds Chronic illnesses Clinical trials Cytokines Damage localization Diet Disease Enzymes Food Gastrointestinal symptoms Gliadin Gliadin - immunology Gliadin - metabolism Gluten Glutens - immunology Glutens - metabolism Growth factors Health services Humans Immune response Immune system Immunosuppression Immunosuppression - methods Inflammation Intestinal Mucosa - drug effects Intestinal Mucosa - immunology Intestinal Mucosa - metabolism Intestine Intestine, Small - drug effects Intestine, Small - immunology Intestine, Small - metabolism Mucosa Pathogenesis Peptides Permeability Polyphenols Polyphenols - immunology Polyphenols - metabolism Polyphenols - therapeutic use Prospective Studies Proteins Review Sequestering Small intestine |
| title | Gliadin Sequestration as a Novel Therapy for Celiac Disease: A Prospective Application for Polyphenols |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-08T18%3A23%3A32IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gliadin%20Sequestration%20as%20a%20Novel%20Therapy%20for%20Celiac%20Disease:%20A%20Prospective%20Application%20for%20Polyphenols&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Van%20Buiten,%20Charlene%20B&rft.date=2021-01-08&rft.volume=22&rft.issue=2&rft.spage=595&rft.pages=595-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms22020595&rft_dat=%3Cproquest_pubme%3E2477380439%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2477380439&rft_id=info:pmid/33435615&rfr_iscdi=true |