Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs

Chronic hepatitis B virus (HBV) infections are one of the leading causes of cirrhosis and hepatocellular carcinoma. N6-methyladenosine (m⁶A) modification of cellular and viral RNAs is the most prevalent internal modification that occurs cotranscriptionally. Previously, we reported the dual functiona...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-01, Vol.118 (3), p.1-9
Hauptverfasser:	Kim, Geon-Woo, Siddiqui, Aleem
Format:	Artikel
Sprache:	eng
Schlagworte:	Biological Sciences Chromatin Cirrhosis Ectopic expression Genomes HBX protein Hepatitis Hepatitis B Hepatocellular carcinoma Homology Immunoprecipitation Life cycles Methylation Methyltransferase N6-methyladenosine Nuclear transport Proteins PTEN protein Tensin Transfection
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