Immature HIV-1 assembles from Gag dimers leaving partial hexamers at lattice edges as potential substrates for proteolytic maturation

The CA (capsid) domain of immature HIV-1 Gag and the adjacent spacer peptide 1 (SP1) play a key role in viral assembly by forming a lattice of CA hexamers, which adapts to viral envelope curvature by incorporating small lattice defects and a large gap at the site of budding. This lattice is stabiliz...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2021-01, Vol.118 (3), p.1-10
Hauptverfasser:	Tan, Aaron, Pak, Alexander J., Morado, Dustin R., Voth, Gregory A., Briggs, John A. G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Assembly Biological Sciences Bundles Bundling Coils Crystal defects Dimers Free energy Gag protein Hexamers HIV Human immunodeficiency virus Maturation Molecular dynamics Oligomerization Proteolysis Substrates
Online-Zugang:	Volltext
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