Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver

•Vagus nerve modulates the phagocytic activity of liver resident macrophages.•The vagal circuitry during sepsis optimizes bacterial clearance in the liver.•Vagal stimulation favors hepatic anti-inflammatory and pro-regenerative cytokines. The gastrointestinal (GI) tract harbors commensal microorgani...

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Veröffentlicht in:Brain, behavior, and immunity behavior, and immunity, 2019-10, Vol.81, p.444-454
Hauptverfasser: Fonseca, Roberta Cristelli, Bassi, Gabriel Shimizu, Brito, Camila Carvalho, Rosa, Lorena Barreto, David, Bruna Araújo, Araújo, Alan Moreira, Nóbrega, Natália, Diniz, Ariane Barros, Jesus, Itamar Couto Guedes, Barcelos, Lucíola Silva, Fontes, Marco Antônio Peliky, Bonaventura, Daniella, Kanashiro, Alexandre, Cunha, Thiago Mattar, Guatimosim, Sílvia, Cardoso, Valbert Nascimento, Fernandes, Simone Odília Antunes, Menezes, Gustavo Batista, de Lartigue, Guillaume, Oliveira, André Gustavo
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container_start_page 444
container_title Brain, behavior, and immunity
container_volume 81
creator Fonseca, Roberta Cristelli
Bassi, Gabriel Shimizu
Brito, Camila Carvalho
Rosa, Lorena Barreto
David, Bruna Araújo
Araújo, Alan Moreira
Nóbrega, Natália
Diniz, Ariane Barros
Jesus, Itamar Couto Guedes
Barcelos, Lucíola Silva
Fontes, Marco Antônio Peliky
Bonaventura, Daniella
Kanashiro, Alexandre
Cunha, Thiago Mattar
Guatimosim, Sílvia
Cardoso, Valbert Nascimento
Fernandes, Simone Odília Antunes
Menezes, Gustavo Batista
de Lartigue, Guillaume
Oliveira, André Gustavo
description •Vagus nerve modulates the phagocytic activity of liver resident macrophages.•The vagal circuitry during sepsis optimizes bacterial clearance in the liver.•Vagal stimulation favors hepatic anti-inflammatory and pro-regenerative cytokines. The gastrointestinal (GI) tract harbors commensal microorganisms as well as invasive bacteria, toxins and other pathogens and, therefore, plays a pivotal barrier and immunological role against pathogenic agents. The vagus nerve is an important regulator of the GI tract-associated immune system, having profound effects on inflammatory responses. Among GI tract organs, the liver is a key site of immune surveillance, as it has a large population of resident macrophages and receives the blood drained from the guts through the hepatic portal circulation. Although it is widely accepted that the hepatic tissue is a major target for vagus nerve fibers, the role of this neural circuit in liver immune functions is still poorly understood. Herein we used in vivo imaging techniques, including confocal microscopy and scintigraphy, to show that vagus nerve stimulation increases the phagocytosis activity by resident macrophages in the liver, even on the absence of an immune challenge. The activation of this neural circuit in a non-lethal model of sepsis optimized the removal of bacteria in the liver and resulted in the production of anti-inflammatory and pro-regenerative cytokines. Our findings provide new insights into the neural regulation of the immune system in the liver.
doi_str_mv 10.1016/j.bbi.2019.06.041
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The gastrointestinal (GI) tract harbors commensal microorganisms as well as invasive bacteria, toxins and other pathogens and, therefore, plays a pivotal barrier and immunological role against pathogenic agents. The vagus nerve is an important regulator of the GI tract-associated immune system, having profound effects on inflammatory responses. Among GI tract organs, the liver is a key site of immune surveillance, as it has a large population of resident macrophages and receives the blood drained from the guts through the hepatic portal circulation. Although it is widely accepted that the hepatic tissue is a major target for vagus nerve fibers, the role of this neural circuit in liver immune functions is still poorly understood. Herein we used in vivo imaging techniques, including confocal microscopy and scintigraphy, to show that vagus nerve stimulation increases the phagocytosis activity by resident macrophages in the liver, even on the absence of an immune challenge. 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source MEDLINE; Elsevier ScienceDirect Journals
subjects Animals
Cholinergic signaling
Cytokines
Female
Gastrointestinal Tract
Kupffer cells
Liver
Liver - immunology
Liver - pathology
Macrophages - immunology
Mice
Mice, Inbred C57BL
Phagocytes - metabolism
Phagocytosis
Phagocytosis - physiology
Sepsis - immunology
Vagus nerve
Vagus Nerve - pathology
Vagus Nerve - physiology
Vagus Nerve Stimulation - methods
title Vagus nerve regulates the phagocytic and secretory activity of resident macrophages in the liver
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