Pernio (Chilblains), SARS-CoV-2, and COVID Toes Unified Through Cutaneous and Systemic Mechanisms

Pernio or chilblains is characterized by erythema and swelling at acral sites (eg, toes and fingers), typically triggered by cold exposure. Clinical and histopathologic features of pernio are well described, but the pathogenesis is not entirely understood; vasospasm and a type I interferon (IFN-I) i...

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Veröffentlicht in:	Mayo Clinic proceedings 2021-04, Vol.96 (4), p.989-1005
Hauptverfasser:	Cappel, Mark A., Cappel, Jonathan A., Wetter, David A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Chilblains - immunology Chilblains - physiopathology Chilblains - virology COVID-19 - immunology COVID-19 - physiopathology Development and progression Disease Susceptibility Fingers - blood supply Health aspects Humans Immune response Interferon Physiological aspects Renin-Angiotensin System - physiology Review Risk factors SARS-CoV-2 - pathogenicity Skin diseases Soft tissue injuries Toes Toes - blood supply Vasoconstriction
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