Estrogen Receptors: Therapeutic Perspectives for the Treatment of Cardiac Dysfunction after Myocardial Infarction

Estrogen receptors (ER) mediate functions beyond their endocrine roles, as modulation of cardiovascular, renal, and immune systems through anti-inflammatory and anti-apoptotic effects, preventing necrosis of cardiomyocytes and endothelial cells, and attenuating cardiac hypertrophy. Estradiol (E2) pr...

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Veröffentlicht in:	International journal of molecular sciences 2021-01, Vol.22 (2), p.525
Hauptverfasser:	da Silva, Jaqueline S, Montagnoli, Tadeu L, Rocha, Bruna S, Tacco, Matheus L C A, Marinho, Sophia C P, Zapata-Sudo, Gisele
Format:	Artikel
Sprache:	eng
Schlagworte:	17β-Estradiol Animals Apoptosis Cardiomyocytes Cardiovascular disease Cardiovascular diseases Cell proliferation Clinical aspects Endothelial cells Endothelial Cells - metabolism Endothelial Cells - pathology Estradiol - therapeutic use Estrogen Receptor alpha - genetics Estrogen Receptor beta - genetics Estrogen receptors Estrogens Estrogens - genetics Estrogens - metabolism Female Genomics Health services Humans Hypertrophy Immune system Inflammation Kinases Mortality Myocardial infarction Myocardial Infarction - drug therapy Myocardial Infarction - genetics Myocardial Infarction - pathology Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Necrosis Nitric oxide Receptors, Estrogen - genetics Receptors, G-Protein-Coupled - genetics Review
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