Comparative Analysis of Tenogenic Gene Expression in Tenocyte-Derived Induced Pluripotent Stem Cells and Bone Marrow-Derived Mesenchymal Stem Cells in Response to Biochemical and Biomechanical Stimuli

The tendon is highly prone to injury, overuse, or age-related degeneration in both humans and horses. Natural healing of injured tendon is poor, and cell-based therapeutic treatment is still a significant clinical challenge. In this study, we extensively investigated the expression of tenogenic gene...

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Veröffentlicht in:	Stem cells international 2021, Vol.2021, p.8835576-18
Hauptverfasser:	Yang, Feikun, Richardson, Dean W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Biomechanics Bone marrow Comparative analysis Degeneration DNA binding proteins Ectopic expression EGR-1 protein Ethylenediaminetetraacetic acid Gene expression Genes Genetic research Growth factors Horses Infections Laboratories Mesenchymal stem cells Pluripotency Regeneration Repair & maintenance SIRT1 protein Smad7 protein Stem cells Stimuli Tendons Transcription factors Transforming growth factors Western blotting Wound healing
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